Pre_GI: BLASTN Hits

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Query: NC_010674:858397 Clostridium botulinum B str. Eklund 17B, complete genome

Start: 858397, End: 878567, Length: 20171

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum B str. Eklund 17B is a nonproteolytic botulism neurotoxin B strain. This strain was isolated from marine sediments taken off the coast of Washington, USA and was not associated with botulism. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

Subject IslandStartEndLengthSubject Host DescriptionE-valueBit scoreVisual BLASTNVisual BLASTP
NC_010723:83387083387085686522996Clostridium botulinum E3 str. Alaska E43, complete genome05779BLASTN svgBLASTP svg
NC_020291:4903981*4903981494131537335Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genome3e-172613BLASTN svgBLASTP svg
NC_008593:11032931103293112464521353Clostridium novyi NT, complete genome2e-117430BLASTN svgBLASTP svg
NC_010520:28609602860960288097120012Clostridium botulinum A3 str. Loch Maree, complete genome9e-74285BLASTN svgBLASTP svg
NC_021182:2883716*2883716290856724852Clostridium pasteurianum BC1, complete genome2e-71278BLASTN svgBLASTP svg
NC_014328:1135854*1135854115915023297Clostridium ljungdahlii ATCC 49587 chromosome, complete genome3e-52214BLASTN svgBLASTP svg
NC_018664:16633241663324168566922346Clostridium acidurici 9a chromosome, complete genome5e-23117BLASTN svgBLASTP svg
NC_019978:62547662547664529019815Halobacteroides halobius DSM 5150, complete genome1e-1179.8BLASTN svgBLASTP svg
NC_004344:26828*268286612639299Wigglesworthia glossinidia endosymbiont of Glossina brevipalpis,2e-0971.9BLASTN svgBLASTP svg
NC_014150:446359*44635946998023622Brachyspira murdochii DSM 12563 chromosome, complete genome6e-0763.9BLASTN svgBLASTP svg
NC_012778:841934*84193489007548142Eubacterium eligens ATCC 27750, complete genome6e-0763.9BLASTN svgBLASTP svg
NC_009012:57414557414559944025296Clostridium thermocellum ATCC 27405, complete genome6e-0763.9BLASTN svgBLASTP svg
NC_015391:2059191*2059191209896139771Carnobacterium sp. 17-4 chromosome, complete genome9e-0660BLASTN svgBLASTP svg