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Query: NC_010674:311378 Clostridium botulinum B str. Eklund 17B, complete genome

Start: 311378, End: 330314, Length: 18937

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum B str. Eklund 17B is a nonproteolytic botulism neurotoxin B strain. This strain was isolated from marine sediments taken off the coast of Washington, USA and was not associated with botulism. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

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Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

Subject IslandStartEndLengthSubject Host DescriptionE-valueBit scoreVisual BLASTNVisual BLASTP
NC_010723:29895429895431770918756Clostridium botulinum E3 str. Alaska E43, complete genome04117BLASTN svgBLASTP svg
NC_020291:27023427023430031730084Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genome01231BLASTN svgBLASTP svg
NC_015687:3302372*3302372332181219441Clostridium acetobutylicum DSM 1731 chromosome, complete genome8e-37163BLASTN svgBLASTP svg
NC_003030:3301342*3301342332018518844Clostridium acetobutylicum ATCC 824, complete genome8e-37163BLASTN svgBLASTP svg
NC_014393:1590893*1590893163877247880Clostridium cellulovorans 743B chromosome, complete genome5e-32147BLASTN svgBLASTP svg
NC_010674:11244311124431114553121101Clostridium botulinum B str. Eklund 17B, complete genome3e-21111BLASTN svgBLASTP svg
NC_009437:1481064*1481064150445323390Caldicellulosiruptor saccharolyticus DSM 8903, complete genome4e-20107BLASTN svgBLASTP svg
NC_012225:12134211213421123659923179Brachyspira hyodysenteriae WA1, complete genome2e-19105BLASTN svgBLASTP svg
NC_010723:420025*42002544661626592Clostridium botulinum E3 str. Alaska E43, complete genome7e-19103BLASTN svgBLASTP svg
NC_018607:15059081505908154680040893Brachyspira pilosicoli B2904 chromosome, complete genome1e-1799.6BLASTN svgBLASTP svg
NC_014330:19544719544722875533309Brachyspira pilosicoli 95/1000 chromosome, complete genome1e-1799.6BLASTN svgBLASTP svg
NC_010723:10840001084000110630222303Clostridium botulinum E3 str. Alaska E43, complete genome6e-1693.7BLASTN svgBLASTP svg
NC_018604:12639271263927128817424248Brachyspira pilosicoli WesB complete genome2e-1591.7BLASTN svgBLASTP svg
NC_014614:47857847857849868920112Clostridium sticklandii, complete genome2e-1385.7BLASTN svgBLASTP svg
NC_019978:22461922461924698422366Halobacteroides halobius DSM 5150, complete genome2e-1281.8BLASTN svgBLASTP svg
NC_010674:3581044*3581044360559924556Clostridium botulinum B str. Eklund 17B, complete genome9e-1279.8BLASTN svgBLASTP svg
NC_014751:225477*22547724539519919Mycoplasma leachii PG50 chromosome, complete genome9e-1279.8BLASTN svgBLASTP svg
NC_014909:662500*66250068970227203Candidatus Blochmannia vafer str. BVAF chromosome, complete genome9e-1279.8BLASTN svgBLASTP svg
NC_015555:447844782276918292Thermoanaerobacterium xylanolyticum LX-11 chromosome, complete9e-1279.8BLASTN svgBLASTP svg
NC_019970:8938*89382966920732Thermoanaerobacterium thermosaccharolyticum M0795, complete genome4e-1177.8BLASTN svgBLASTP svg
NC_014410:8694*86942877520082Thermoanaerobacterium thermosaccharolyticum DSM 571 chromosome,4e-1177.8BLASTN svgBLASTP svg
NC_014654:15816891581689160373022042Halanaerobium sp. 'sapolanicus' chromosome, complete genome1e-1075.8BLASTN svgBLASTP svg
NC_005061:647567*64756767214524579Candidatus Blochmannia floridanus, complete genome2e-0971.9BLASTN svgBLASTP svg
NC_010674:33620713362071338633124261Clostridium botulinum B str. Eklund 17B, complete genome2e-0971.9BLASTN svgBLASTP svg
NC_014328:22034372203437222518421748Clostridium ljungdahlii ATCC 49587 chromosome, complete genome2e-0971.9BLASTN svgBLASTP svg
NC_015958:11511115113009918589Thermoanaerobacter wiegelii Rt8.B1 chromosome, complete genome9e-0969.9BLASTN svgBLASTP svg
NC_009850:1011293*1011293103921027918Arcobacter butzleri RM4018, complete genome9e-0969.9BLASTN svgBLASTP svg
NC_003869:14153*141533317319021Thermoanaerobacter tengcongensis MB4, complete genome9e-0969.9BLASTN svgBLASTP svg
NC_005364:17709117709119836621276Mycoplasma mycoides subsp. mycoides SC str. PG1, complete genome4e-0867.9BLASTN svgBLASTP svg
NC_010003:17245001724500174259918100Petrotoga mobilis SJ95, complete genome1e-0765.9BLASTN svgBLASTP svg
NC_014721:508000*50800053060122602Caldicellulosiruptor kristjanssonii 177R1B chromosome, complete1e-0765.9BLASTN svgBLASTP svg
NC_015949:1957185*1957185197800220818Caldicellulosiruptor lactoaceticus 6A chromosome, complete genome1e-0765.9BLASTN svgBLASTP svg
NC_003366:64908*6490811367548768Clostridium perfringens str. 13, complete genome6e-0763.9BLASTN svgBLASTP svg
NC_008261:64678*6467810124836571Clostridium perfringens ATCC 13124, complete genome6e-0763.9BLASTN svgBLASTP svg
NC_008262:101731*10173112528023550Clostridium perfringens SM101, complete genome6e-0763.9BLASTN svgBLASTP svg
NC_010723:915697*91569793892123225Clostridium botulinum E3 str. Alaska E43, complete genome6e-0763.9BLASTN svgBLASTP svg
NC_014150:25012992501299252472923431Brachyspira murdochii DSM 12563 chromosome, complete genome2e-0661.9BLASTN svgBLASTP svg
NC_003997:13340001334000135620422205Bacillus anthracis str. Ames, complete genome9e-0660BLASTN svgBLASTP svg
NC_005945:13340001334000135609922100Bacillus anthracis str. Sterne, complete genome9e-0660BLASTN svgBLASTP svg
NC_007530:13327681332768135609923332Bacillus anthracis str. 'Ames Ancestor', complete genome9e-0660BLASTN svgBLASTP svg
NC_010674:16729901672990169323120242Clostridium botulinum B str. Eklund 17B, complete genome9e-0660BLASTN svgBLASTP svg
NC_014335:1329414*1329414135274423331Bacillus cereus biovar anthracis str. CI chromosome, complete9e-0660BLASTN svgBLASTP svg
NC_015687:95918*9591811738721470Clostridium acetobutylicum DSM 1731 chromosome, complete genome9e-0660BLASTN svgBLASTP svg
NC_003030:95918*9591811738721470Clostridium acetobutylicum ATCC 824, complete genome9e-0660BLASTN svgBLASTP svg