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Query: NC_010674:2856997 Clostridium botulinum B str. Eklund 17B, complete genome

Start: 2856997, End: 2879248, Length: 22252

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum B str. Eklund 17B is a nonproteolytic botulism neurotoxin B strain. This strain was isolated from marine sediments taken off the coast of Washington, USA and was not associated with botulism. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

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Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

Subject IslandStartEndLengthSubject Host DescriptionE-valueBit scoreVisual BLASTNVisual BLASTP
NC_003366:14277851427785145027522491Clostridium perfringens str. 13, complete genome01154BLASTN svgBLASTP svg
NC_008593:18598611859861188348723627Clostridium novyi NT, complete genome6e-180638BLASTN svgBLASTP svg
NC_010674:20114032011403203176320361Clostridium botulinum B str. Eklund 17B, complete genome2e-115424BLASTN svgBLASTP svg
NC_012781:19688271968827200279833972Eubacterium rectale ATCC 33656, complete genome9e-65256BLASTN svgBLASTP svg
NC_018664:15929115929118728527995Clostridium acidurici 9a chromosome, complete genome3e-64254BLASTN svgBLASTP svg
NC_004663:16315216315218293619785Bacteroides thetaiotaomicron VPI-5482, complete genome7e-50206BLASTN svgBLASTP svg
NC_015737:981712*98171299969317982Clostridium sp. SY8519, complete genome7e-1693.7BLASTN svgBLASTP svg
NC_014972:19230351923035194350220468Desulfobulbus propionicus DSM 2032 chromosome, complete genome7e-1693.7BLASTN svgBLASTP svg
NC_010516:3903867*3903867395059846732Clostridium botulinum B1 str. Okra, complete genome3e-1591.7BLASTN svgBLASTP svg
NC_011898:351792*35179237417622385Clostridium cellulolyticum H10, complete genome4e-0867.9BLASTN svgBLASTP svg