Pre_GI: BLASTN Hits

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Query: NC_010674:2817651 Clostridium botulinum B str. Eklund 17B, complete genome

Start: 2817651, End: 2837765, Length: 20115

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum B str. Eklund 17B is a nonproteolytic botulism neurotoxin B strain. This strain was isolated from marine sediments taken off the coast of Washington, USA and was not associated with botulism. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

Subject IslandStartEndLengthSubject Host DescriptionE-valueBit scoreVisual BLASTNVisual BLASTP
NC_010674:23283072328307234841320107Clostridium botulinum B str. Eklund 17B, complete genome4e-153549BLASTN svgBLASTP svg
NC_010674:19860001986000200848422485Clostridium botulinum B str. Eklund 17B, complete genome3e-104387BLASTN svgBLASTP svg
NC_020291:795500*79550085457259073Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genome1e-32149BLASTN svgBLASTP svg
NC_012563:29254722925472296409938628Clostridium botulinum A2 str. Kyoto, complete genome2e-22115BLASTN svgBLASTP svg
NC_012563:17043451704345173190427560Clostridium botulinum A2 str. Kyoto, complete genome4e-20107BLASTN svgBLASTP svg
NC_014393:19016881901688192179720110Clostridium cellulovorans 743B chromosome, complete genome2e-1385.7BLASTN svgBLASTP svg
NC_012563:21014492101449212008818640Clostridium botulinum A2 str. Kyoto, complete genome1e-1179.8BLASTN svgBLASTP svg
NC_012563:25665002566500258437417875Clostridium botulinum A2 str. Kyoto, complete genome1e-0869.9BLASTN svgBLASTP svg
NC_010674:33620713362071338633124261Clostridium botulinum B str. Eklund 17B, complete genome2e-0661.9BLASTN svgBLASTP svg