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Query: NC_010674:950276:965927 Clostridium botulinum B str. Eklund 17B, complete genome

Start: 965927, End: 967612, Length: 1686

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum B str. Eklund 17B is a nonproteolytic botulism neurotoxin B strain. This strain was isolated from marine sediments taken off the coast of Washington, USA and was not associated with botulism. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010723:2269372:2270908227090822726531746Clostridium botulinum E3 str. Alaska E43, complete genomeputative phage endopeptidase2e-103377
NC_010674:2328307:2334367233436723361091743Clostridium botulinum B str. Eklund 17B, complete genomeputative phage endopeptidase2e-84313
NC_015425:1295261:1323547132354713252351689Clostridium botulinum BKT015925 chromosome, complete genomephage endopeptidase2e-37157
NC_008593:1362218:1367575136757513693861812Clostridium novyi NT, complete genomePhage endopeptidase1e-35151
NC_011773:549500:5586185586185610412424Bacillus cereus AH820 chromosome, complete genomephage endopeptidase2e-31137
NC_010520:2101515:2113177211317721148591683Clostridium botulinum A3 str. Loch Maree, complete genomephage endopeptidase3e-31137
NC_003212:2592600:2592600259260025947412142Listeria innocua Clip11262, complete genomehypothetical protein2e-27124
NC_008555:1204000:1237369123736912395102142Listeria welshimeri serovar 6b str. SLCC5334, complete genomephage-related structural protein2e-25117
NC_004070:1231883:1240251124025112423952145Streptococcus pyogenes MGAS315, complete genomehypothetical protein3e-25117
NC_007296:1230614:1237561123756112397082148Streptococcus pyogenes MGAS6180, complete genomephage endopeptidase3e-25117
NC_012471:781063:8139308139308160712142Streptococcus equi subsp. equi 4047, complete genomephage protein6e-25116
NC_006086:987991:9974769974769996202145Streptococcus pyogenes MGAS10394, complete genomePhage endopeptidase3e-24114
NC_006086:1329915:1339940133994013420872148Streptococcus pyogenes MGAS10394, complete genomePhage endopeptidase2e-24114
NC_002737:533291:5605685605685627122145Streptococcus pyogenes M1 GAS, complete genomehypothetical protein2e-24114
NC_009332:1269000:1277102127710212792462145Streptococcus pyogenes str. Manfredo chromosome, complete genomehypothetical protein1e-23111
NC_008022:1255210:1264662126466212668062145Streptococcus pyogenes MGAS10270, complete genomephage endopeptidase1e-23111
NC_008024:572916:5798995798995820432145Streptococcus pyogenes MGAS10750, complete genomephage endopeptidase1e-23111
NC_008022:556457:5627225627225648662145Streptococcus pyogenes MGAS10270, complete genomephage endopeptidase1e-23111
NC_008021:531730:5614455614455635892145Streptococcus pyogenes MGAS9429, complete genomephage endopeptidase1e-23111
NC_014246:1402500:1428313142831314309762664Mobiluncus curtisii ATCC 43063 chromosome, complete genomeputative phage endopeptidase5e-21103
NC_003485:602640:6093496093496113251977Streptococcus pyogenes MGAS8232, complete genomehypothetical protein2e-1894.7
NC_020291:1122282:1137850113785011396311782Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomephage minor structural protein4e-1687
NC_008261:1787345:1791790179179017948493060Clostridium perfringens ATCC 13124, complete genomeputative phage structural protein3e-1583.6
NC_020291:795500:8255588255588276872130Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomephage minor structural protein8e-1375.9
NC_014498:62891:6643766437745368100Streptococcus pneumoniae 670-6B chromosome, complete genomePblB6e-1169.7
NC_004116:1827351:1836950183695018406243675Streptococcus agalactiae 2603V/R, complete genomeprophage LambdaSa2, PblB, putative1e-0965.1
NC_014494:47049:4704947049561569108Streptococcus pneumoniae AP200 chromosome, complete genomePblB, putative4e-0653.5