Pre_GI: BLASTP Hits

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Query: NC_010674:828191:843699 Clostridium botulinum B str. Eklund 17B, complete genome

Start: 843699, End: 844541, Length: 843

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum B str. Eklund 17B is a nonproteolytic botulism neurotoxin B strain. This strain was isolated from marine sediments taken off the coast of Washington, USA and was not associated with botulism. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_015578:247266:267581267581268276696Treponema primitia ZAS-2 chromosome, complete genomeO-methyltransferase5e-51201
NC_014376:3732547:373753637375363738384849Clostridium saccharolyticum WM1 chromosome, complete genomeputative O-methyltransferase3e-50198
NC_015977:189101:194948194948195778831Roseburia hominis A2-183 chromosome, complete genomeO-methyltransferase2e-49196
NC_015578:247266:288040288040288423384Treponema primitia ZAS-2 chromosome, complete genomeO-methyltransferase2e-26119
NC_014315:2711852:272008627200862720811726Nitrosococcus watsoni C-113 chromosome, complete genomehypothetical protein2e-1170.1
NC_020291:4944835:4976955497695549780731119Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomeputative chemotaxis response regulator4e-1168.9
NC_017904:3415700:345534634553463456173828Mycobacterium sp. MOTT36Y chromosome, complete genomemacrocin-O-methyltransferase5e-0962
NC_016948:3381848:342549334254933426314822Mycobacterium intracellulare MOTT-64 chromosome, complete genomeMtfB protein5e-0961.6
NC_016947:3309898:335351033535103354331822Mycobacterium intracellulare MOTT-02 chromosome, complete genomeMtfB protein5e-0961.6
NC_014759:2598515:261746026174602618167708Marivirga tractuosa DSM 4126 chromosome, complete genomehypothetical protein3e-0859.3
NC_014166:2959688:296996629699662970844879Arcobacter nitrofigilis DSM 7299 chromosome, complete genomeLicD family protein3e-0859.3
NC_016604:297687:330241330241331029789Mycobacterium rhodesiae NBB3 chromosome, complete genomeMacrocin-O-methyltransferase (TylF)1e-0757.4
NC_014355:3398033:341101534110153411851837Candidatus Nitrospira defluvii, complete genomehypothetical protein1e-0757.4
NC_016604:297687:329309329309330115807Mycobacterium rhodesiae NBB3 chromosome, complete genomeMacrocin-O-methyltransferase (TylF)2e-0756.6
NC_017904:3415700:345051734505173451320804Mycobacterium sp. MOTT36Y chromosome, complete genomeMtfD protein3e-0756.2
NC_016947:3309898:334862833486283349431804Mycobacterium intracellulare MOTT-02 chromosome, complete genomeMtfD protein5e-0755.1
NC_016948:3381848:342061134206113421414804Mycobacterium intracellulare MOTT-64 chromosome, complete genomeMtfD protein5e-0755.1
NC_007775:1002934:1029768102976810324612694Synechococcus sp. JA-3-3Ab, complete genomemacrocin-O-methyltransferase domain protein1e-0653.9
NC_010397:4150596:416472941647294165517789Mycobacterium abscessus chromosome Chromosome, complete sequenceMethyltransferase MtfD2e-0653.1