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Query: NC_010674:828191:840328 Clostridium botulinum B str. Eklund 17B, complete genome

Start: 840328, End: 840675, Length: 348

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum B str. Eklund 17B is a nonproteolytic botulism neurotoxin B strain. This strain was isolated from marine sediments taken off the coast of Washington, USA and was not associated with botulism. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010723:801215:817508817508817855348Clostridium botulinum E3 str. Alaska E43, complete genomehypothetical protein2e-58224
NC_009698:2727203:272863327286332728980348Clostridium botulinum A str. Hall chromosome, complete genomehypothetical protein1e-27121
NC_009697:2790277:279170727917072792054348Clostridium botulinum A str. ATCC 19397 chromosome, completehypothetical protein1e-27121
NC_009495:2876865:287829528782952878642348Clostridium botulinum A str. ATCC 3502 chromosome, complete genomehypothetical protein1e-27121
NC_012563:3090954:309238430923843092731348Clostridium botulinum A2 str. Kyoto, complete genomehypothetical protein1e-27121
NC_015425:1207314:122408512240851224432348Clostridium botulinum BKT015925 chromosome, complete genomehypothetical protein1e-23108
NC_017295:2286911:229399922939992294346348Clostridium acetobutylicum EA 2018 chromosome, complete genomehypothetical protein3e-23107
NC_009699:2901497:290465329046532905000348Clostridium botulinum F str. Langeland chromosome, complete genomehypothetical protein5e-23106
NC_020291:4944835:498170649817064982053348Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomehypothetical protein5e-2096.3
NC_009012:2661795:266179526617952662178384Clostridium thermocellum ATCC 27405, complete genomehypothetical protein9e-1785.5
NC_014614:2434017:245516224551622455518357Clostridium sticklandii, complete genomehypothetical protein5e-1166.2
NC_014650:376070:382962382962383324363Geobacillus sp. Y4.1MC1 chromosome, complete genomehypothetical protein4e-1063.5
NC_015660:391627:398074398074398427354Geobacillus thermoglucosidasius C56-YS93 chromosome, completehypothetical protein3e-0960.5
NC_014915:3259440:327859632785963279180585Geobacillus sp. Y412MC52 chromosome, complete genomehypothetical protein2e-0858.2
NC_011899:1807365:182386718238671824472606Halothermothrix orenii H 168, complete genomehypothetical protein3e-0857.4
NC_015589:1240197:125006612500661250419354Desulfotomaculum ruminis DSM 2154 chromosome, complete genomehypothetical protein4e-0753.5
NC_010337:748467:762596762596763147552Heliobacterium modesticaldum Ice1, complete genomehypothetical protein5e-0650.1
NC_014829:3877701:387873638787363879344609Bacillus cellulosilyticus DSM 2522 chromosome, complete genomehypothetical protein8e-0649.3