Pre_GI: BLASTP Hits

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Query: NC_010674:828191:830247 Clostridium botulinum B str. Eklund 17B, complete genome

Start: 830247, End: 830603, Length: 357

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum B str. Eklund 17B is a nonproteolytic botulism neurotoxin B strain. This strain was isolated from marine sediments taken off the coast of Washington, USA and was not associated with botulism. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010520:2937981:294759429475942947950357Clostridium botulinum A3 str. Loch Maree, complete genomeflaG family protein3e-0857.4
NC_012563:3090954:310224231022423102598357Clostridium botulinum A2 str. Kyoto, complete genomeflaG family protein6e-0856.2
NC_010516:2900057:290723729072372907593357Clostridium botulinum B1 str. Okra, complete genomeflaG family protein2e-0857.8
NC_012658:2930244:293974929397492940105357Clostridium botulinum Ba4 str. 657 chromosome, complete genomeflaG family protein4e-0856.6
NC_010723:801215:807427807427807783357Clostridium botulinum E3 str. Alaska E43, complete genomeflaG family protein5e-49192
NC_017297:2905138:291191429119142912270357Clostridium botulinum F str. 230613 chromosome, complete genomeflaG family protein3e-0857.4
NC_020210:3169258:317136131713613171723363Geobacillus sp. GHH01, complete genomeflagellar protein2e-0651.2
NC_020291:4944835:498778149877814988152372Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomeflagellar protein FlaG2e-1891.3
NC_009495:2876865:288815328881532888509357Clostridium botulinum A str. ATCC 3502 chromosome, complete genomeflagellar protein FlaG6e-0856.2
NC_017195:3426000:343334434333443433535192Bacillus subtilis subsp. subtilis str. RO-NN-1 chromosome, completeflagellar protein FlaG7e-0752.8
NC_020134:2772500:277491427749142775231318Clostridium stercorarium subsp. stercorarium DSM 8532, completeflagellar protein FlaG8e-0649.3
NC_009699:2901497:291177629117762912132357Clostridium botulinum F str. Langeland chromosome, complete genomeflagellar protein FlaG3e-0857.4
NC_009697:2790277:280156528015652801921357Clostridium botulinum A str. ATCC 19397 chromosome, completeflagellar protein FlaG6e-0856.2
NC_021182:2921000:293178729317872932161375Clostridium pasteurianum BC1, complete genomeflagellar protein FlaG3e-0753.9
NC_006510:3133965:313683931368393137198360Geobacillus kaustophilus HTA426, complete genomeflagellar protein FlaG6e-0752.8
NC_018664:239000:260860260860261222363Clostridium acidurici 9a chromosome, complete genomeflagellar protein FlaG5e-0649.7
NC_009698:2727203:273849127384912738847357Clostridium botulinum A str. Hall chromosome, complete genomeflagellar protein FlaG6e-0856.2
NC_013791:1082951:108669810866981087057360Bacillus pseudofirmus OF4 chromosome, complete genomeflagellar protein FlaG1e-0755.1
NC_015519:924000:927863927863928231369Tepidanaerobacter sp. Re1 chromosome, complete genomeflagellar protein FlaG protein4e-0753.5
NC_014377:1546124:156057415605741560942369Thermosediminibacter oceani DSM 16646 chromosome, complete genomeflagellar protein FlaG protein8e-0752.4
NC_015660:391627:410893410893411243351Geobacillus thermoglucosidasius C56-YS93 chromosome, completeflagellar protein FlaG protein5e-0649.7
NC_013411:3251500:325302732530273253386360Geobacillus sp. Y412MC61, complete genomeflagellar protein FlaG protein2e-0650.8
NC_009617:4946000:494994149499414950315375Clostridium beijerinckii NCIMB 8052 chromosome, complete genomeflagellar protein FlaG protein5e-1992.8
NC_014650:376070:399512399512399862351Geobacillus sp. Y4.1MC1 chromosome, complete genomeflagellar protein FlaG protein5e-0649.7
NC_004557:1826977:183304618330461833435390Clostridium tetani E88, complete genomeflagellin5e-0856.6
NC_017295:2286911:230027923002792300629351Clostridium acetobutylicum EA 2018 chromosome, complete genomeFlagellin family protein4e-1270.1
NC_015425:1207314:121811412181141218452339Clostridium botulinum BKT015925 chromosome, complete genomeflagellin family protein1e-0962
NC_019896:577594:590244590244590588345Bacillus subtilis subsp. subtilis str. BSP1 chromosome, completehypothetical protein4e-0753.5
NC_012491:5628000:563613356361335636468336Brevibacillus brevis NBRC 100599, complete genomehypothetical protein7e-0959.3
NC_014328:1046958:106493910649391065298360Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeputative flagellar protein9e-0752.4
NC_012781:3087467:309568130956813096142462Eubacterium rectale ATCC 33656, complete genomeuncharacterized flagellar protein FlaG4e-0753.5