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Query: NC_010674:658596:672363 Clostridium botulinum B str. Eklund 17B, complete genome

Start: 672363, End: 673076, Length: 714

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum B str. Eklund 17B is a nonproteolytic botulism neurotoxin B strain. This strain was isolated from marine sediments taken off the coast of Washington, USA and was not associated with botulism. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010723:622928:637556637556638263708Clostridium botulinum E3 str. Alaska E43, complete genomehypothetical protein8e-107386
NC_015977:255029:273093273093273812720Roseburia hominis A2-183 chromosome, complete genomehypothetical protein1e-25116
NC_012225:236490:246777246777247469693Brachyspira hyodysenteriae WA1, complete genomehypothetical protein6e-30130
NC_010397:4909957:490995749099574910622666Mycobacterium abscessus chromosome Chromosome, complete sequencehypothetical protein2e-1376.3
NC_017243:1323870:133558213355821336274693Brachyspira intermedia PWS/A chromosome, complete genomehypothetical protein4e-30131
NC_016605:766836:780022780022780582561Pediococcus claussenii ATCC BAA-344 chromosome, complete genomehypothetical protein3e-1995.5
NC_012470:1635516:165485116548511655549699Streptococcus equi subsp. zooepidemicus, complete genomemembrane protein7e-0650.8
NC_014150:1:655665567248693Brachyspira murdochii DSM 12563 chromosome, complete genomeprotein of unknown function DUF12751e-26120