Pre_GI: BLASTP Hits

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Query: NC_010674:615963:625571 Clostridium botulinum B str. Eklund 17B, complete genome

Start: 625571, End: 626902, Length: 1332

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum B str. Eklund 17B is a nonproteolytic botulism neurotoxin B strain. This strain was isolated from marine sediments taken off the coast of Washington, USA and was not associated with botulism. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010723:575254:5896775896775910081332Clostridium botulinum E3 str. Alaska E43, complete genomeproteoglycan0834
NC_014632:113420:1321301321301334581329Ilyobacter polytropus DSM 2926 chromosome, complete genomeselenium metabolism protein SsnA4e-171601
NC_017179:3540739:3552204355220435535321329Clostridium difficile BI1, complete genomeputative chlorohydrolase/aminohydrolase7e-166583
NC_013315:3532721:3544186354418635455141329Clostridium difficile CD196 chromosome, complete genomechlorohydrolase/aminohydrolase7e-166583
NC_012563:3288124:3304801330480133061291329Clostridium botulinum A2 str. Kyoto, complete genomeamidohydrolase family protein3e-152538
NC_012658:3126108:3142503314250331438311329Clostridium botulinum Ba4 str. 657 chromosome, complete genomeputative chlorohydrolase/aminohydrolase6e-152537
NC_009495:3051223:3067819306781930691471329Clostridium botulinum A str. ATCC 3502 chromosome, complete genomechlorohydrolase/aminohydrolase2e-151536
NC_009697:2984173:3000769300076930020971329Clostridium botulinum A str. ATCC 19397 chromosome, completechlorohydrolase/aminohydrolase2e-151536
NC_009698:2921097:2937693293769329390211329Clostridium botulinum A str. Hall chromosome, complete genomechlorohydrolase/aminohydrolase2e-151536
NC_010520:3120500:3138168313816831394961329Clostridium botulinum A3 str. Loch Maree, complete genomeamidohydrolase family protein8e-151533
NC_014150:2994000:3009675300967530110061332Brachyspira murdochii DSM 12563 chromosome, complete genomeselenium metabolism protein SsnA4e-137488
NC_012225:47800:7289572895742261332Brachyspira hyodysenteriae WA1, complete genomechlorohydrolase/aminohydrolase9e-137487
NC_018604:2253539:2267186226718622685171332Brachyspira pilosicoli WesB complete genomeamidohydrolase family protein SsnA2e-136486
NC_014330:768232:8043968043968057271332Brachyspira pilosicoli 95/1000 chromosome, complete genomeamidohydrolase family protein SsnA2e-136486
NC_019908:2401577:2415375241537524167061332Brachyspira pilosicoli P43/6/78 chromosome, complete genomechlorohydrolase/aminohydrolase2e-136486
NC_017243:2190000:2218864221886422201951332Brachyspira intermedia PWS/A chromosome, complete genomechlorohydrolase/aminohydrolase4e-136484
NC_021182:434351:4448354448354461721338Clostridium pasteurianum BC1, complete genomeputative selenium metabolism protein SsnA2e-125449
NC_014654:2311818:2316109231610923174401332Halanaerobium sp. 'sapolanicus' chromosome, complete genomeselenium metabolism protein SsnA2e-99362
NC_019978:1022209:1037097103709710384281332Halobacteroides halobius DSM 5150, complete genomeputative selenium metabolism protein SsnA1e-98360
NC_011653:331986:3521323521323534151284Thermosipho africanus TCF52B, complete genomeprotein SsnA3e-68259
NC_003901:2685716:2717501271750127188741374Methanosarcina mazei Go1, complete genomeN-ethylammeline chlorohydrolase8e-51201
NC_015958:1516944:1531836153183615331341299Thermoanaerobacter wiegelii Rt8.B1 chromosome, complete genome5-methylthioadenosine/S-adenosylhomocysteine deaminase7e-51201
NC_016584:4860360:4883128488312848844321305Desulfosporosinus orientis DSM 765 chromosome, complete genomecytosine deaminase6e-51201
NC_013315:2232339:2237486223748622387991314Clostridium difficile CD196 chromosome, complete genomeamidohydrolase2e-49196
NC_013316:2309694:2318040231804023193531314Clostridium difficile R20291, complete genomeputative amidohydrolase2e-49196
NC_014253:729996:7492297492297505211293Methanohalobium evestigatum Z-7303 chromosome, complete genomeamidohydrolase1e-47191
NC_015676:546895:5468955468955482051311Methanosalsum zhilinae DSM 4017 chromosome, complete genomeamidohydrolase5e-46185
NC_000909:1517461:1517461151746115187231263Methanocaldococcus jannaschii DSM 2661, complete genomeN-ethylammeline chlorohydrolase (trzA)1e-44181
NC_014623:7133149:7146017714601771473511335Stigmatella aurantiaca DW4/3-1 chromosome, complete genome5-methylthioadenosine/s-adenosylhomocysteine deaminase4e-44179
NC_011297:787932:7889637889637902431281Dictyoglomus thermophilum H-6-12, complete genomeamidohydrolase family9e-44178
NC_011297:767333:7889637889637902431281Dictyoglomus thermophilum H-6-12, complete genomeamidohydrolase family9e-44178
NC_018876:996855:1006097100609710073951299Methanolobus psychrophilus R15 chromosome, complete genomeN-ethylammeline chlorohydrolase2e-43177
NC_014364:394899:4563214563214576761356Spirochaeta smaragdinae DSM 11293 chromosome, complete genomeamidohydrolase5e-41169
NC_019977:1897556:1907287190728719085881302Methanomethylovorans hollandica DSM 15978, complete genomecytosine deaminase-like metal-dependent hydrolase3e-41169
NC_007681:218921:2462962462962475731278Methanosphaera stadtmanae DSM 3091, complete genomepredicted metal-dependent hydrolase6e-41168
NC_013315:2232339:2242432224243222438561425Clostridium difficile CD196 chromosome, complete genomeamidohydrolase2e-40167
NC_013316:2309694:2322986232298623244101425Clostridium difficile R20291, complete genomeputative amidohydrolase2e-40167
NC_007955:1254051:1273264127326412745681305Methanococcoides burtonii DSM 6242, complete genomeamidohydrolase2e-40167
NC_009922:411434:4259964259964273301335Alkaliphilus oremlandii OhILAs, complete genomeamidohydrolase5e-40165
NC_010723:575254:5914445914445928051362Clostridium botulinum E3 str. Alaska E43, complete genomehydroxydechloroatrazine ethylaminohydrolase5e-40165
NC_010501:3448389:3475578347557834769631386Pseudomonas putida W619, complete genomeamidohydrolase2e-39163
NC_015474:72103:8973989739910071269Pyrococcus sp. NA2 chromosome, complete genomeN-ethylammeline chlorohydrolase4e-38159
NC_010674:615963:6276806276806290411362Clostridium botulinum B str. Eklund 17B, complete genomehydroxydechloroatrazine ethylaminohydrolase5e-38159
NC_015658:1:7707770790291323Halopiger xanaduensis SH-6 plasmid pHALXA01, complete sequenceS-adenosylhomocysteine deaminase9e-37154
NC_006395:217139:2407492407492420831335Haloarcula marismortui ATCC 43049 plasmid pNG700, completeN-ethylammeline chlorohydrolase2e-36153
NC_009727:1542000:1542598154259815439531356Coxiella burnetii Dugway 7E9-12, complete genomeamidohydrolase family protein1e-35151
NC_011527:1443076:1441635144163514430891455Coxiella burnetii CbuG_Q212, complete genomechlorohydrolase/deaminase family protein1e-35151
NC_011528:1282691:1281250128125012827041455Coxiella burnetii CbuK_Q154, complete genomechlorohydrolase/deaminase family protein1e-35151
NC_013744:159861:1751081751081764361329Haloterrigena turkmenica DSM 5511 plasmid pHTUR01, completeamidohydrolase1e-34147
NC_012029:45462:6423164231655651335Halorubrum lacusprofundi ATCC 49239 chromosome 1, complete genomeamidohydrolase4e-34145
NC_015731:2811579:2811579281157928129101332Nitrosomonas sp. Is79A3 chromosome, complete genome5-methylthioadenosine/S-adenosylhomocysteine deaminase4e-34145
NC_014315:2327083:2329675232967523310031329Nitrosococcus watsoni C-113 chromosome, complete genomeamidohydrolase9e-33141
NC_013967:2760473:2760473276047327617861314Haloferax volcanii DS2 chromosome, complete genomecytosine deaminase3e-32139
NC_010003:795355:8110198110198123471329Petrotoga mobilis SJ95, complete genomeamidohydrolase9e-32138
NC_019978:1022209:1035696103569610370541359Halobacteroides halobius DSM 5150, complete genomecytosine deaminase-like metal-dependent hydrolase2e-31137
NC_007404:974461:1007134100713410084591326Thiobacillus denitrificans ATCC 25259, complete genomeN-ethylammeline chlorohydrolase5e-31135
NC_014328:2872721:2893648289364828949521305Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeputative amidohydrolase8e-31135
NC_014364:2863686:2863686286368628650921407Spirochaeta smaragdinae DSM 11293 chromosome, complete genomeamidohydrolase1e-30134
NC_015388:719669:7369847369847383211338Desulfobacca acetoxidans DSM 11109 chromosome, complete genome5-methylthioadenosine/S- adenosylhomocysteinedeaminase3e-30133
NC_014654:2311818:2317473231747323188491377Halanaerobium sp. 'sapolanicus' chromosome, complete genomeS-adenosylhomocysteine deaminase3e-29130
NC_015681:1201926:1204632120463212059421311Thermodesulfatator indicus DSM 15286 chromosome, complete genomeamidohydrolase2e-29130
NC_009051:1074993:1076713107671310780201308Methanoculleus marisnigri JR1, complete genomeamidohydrolase1e-29130
NC_014364:3001597:3029161302916130305311371Spirochaeta smaragdinae DSM 11293 chromosome, complete genomeamidohydrolase1e-28127
NC_020210:2133996:2179010217901021804371428Geobacillus sp. GHH01, complete genomehydroxydechloroatrazine ethylaminohydrolase2e-27123
NC_014666:7222000:7226601722660172280371437Frankia sp. EuI1c chromosome, complete genomeamidohydrolase3e-26119
NC_015865:3657:90349034102901257Thermococcus sp. 4557 chromosome, complete genomemetal-dependent amidohydrolase1e-25118
NC_015499:309394:3175213175213188011281Thermodesulfobium narugense DSM 14796 chromosome, complete genome5-methylthioadenosine/S- adenosylhomocysteinedeaminase1e-25117
NC_015859:3346473:3356901335690133584331533Corynebacterium variabile DSM 44702 chromosome, complete genomeputative amidohydrolase1e-25117
NC_015152:2622000:2633671263367126350021332Spirochaeta sp. Buddy chromosome, complete genomeS-adenosylhomocysteine deaminase6e-25115
NC_004129:4993974:5019392501939250207231332Pseudomonas fluorescens Pf-5, complete genomeN-ethylammeline chlorohydrolase6e-24112
NC_018691:3437821:3437821343782134392181398Alcanivorax dieselolei B5 chromosome, complete genomeCytosine deaminase-related metal-dependent hydrolase3e-23109
NC_018515:1354511:1369392136939213707231332Desulfosporosinus meridiei DSM 13257 chromosome, complete genomecytosine deaminase6e-23108
NC_015151:1403500:1419154141915414204911338Vulcanisaeta moutnovskia 768-28 chromosome, complete genomeamidohydrolase9e-22105
NC_009654:4624459:4633743463374346351011359Marinomonas sp. MWYL1, complete genomeamidohydrolase2e-21104
NC_016027:2387832:2392715239271523940791365Gluconacetobacter xylinus NBRC 3288, complete genomehydroxydechloroatrazine ethylaminohydrolase2e-21103
NC_016633:14000:1419814198155981401Sphaerochaeta pleomorpha str. Grapes chromosome, complete genomecytosine deaminase2e-21103
NC_012622:1333000:1345962134596213471971236Sulfolobus islandicus Y.G.57.14 chromosome, complete genomeamidohydrolase4e-21103
NC_012589:1434707:1456589145658914578241236Sulfolobus islandicus L.S.2.15, complete genomeamidohydrolase4e-21103
NC_016584:1436710:1436710143671014380411332Desulfosporosinus orientis DSM 765 chromosome, complete genomecytosine deaminase2e-20100
NC_006351:2759708:2763357276335727647901434Burkholderia pseudomallei K96243 chromosome 2, complete sequencechrolohydrolase6e-2099
NC_009075:1638789:1649346164934616507791434Burkholderia pseudomallei 668 chromosome II, complete sequenceamidohydrolase family protein1e-1998.2
NC_014210:2638773:2658379265837926597401362Nocardiopsis dassonvillei subsp. dassonvillei DSM 43111 chromosome,amidohydrolase1e-1998.2
NC_016906:839406:8380818380818394091329Gordonia polyisoprenivorans VH2 chromosome, complete genomeputative amidohydrolase1e-1997.8
NC_006322:2173500:2190903219090321922521350Bacillus licheniformis ATCC 14580, complete genomehypothetical protein6e-1995.5
NC_006270:2172693:2190058219005821914071350Bacillus licheniformis ATCC 14580, complete genomehypothetical protein6e-1995.5
NC_008712:215499:2323542323542338261473Arthrobacter aurescens TC1 plasmid TC1, complete sequencehydroxyatrazine hydrolase3e-1790.1
NC_013665:2132000:2132670213267021338421173Methanocella paludicola SANAE, complete genomeamidohydrolase family protein2e-1687.4
NC_008609:3732192:3763808376380837650941287Pelobacter propionicus DSM 2379, complete genomeamidohydrolase3e-1686.7
NC_003030:303812:3215643215643228501287Clostridium acetobutylicum ATCC 824, complete genomeCytosine/guanine deaminase related protein2e-1377.8
NC_015687:303810:3215613215613228471287Clostridium acetobutylicum DSM 1731 chromosome, complete genomecytosine/guanine deaminase-like protein2e-1377.8
NC_016612:5231065:5264156526415652655531398Klebsiella oxytoca KCTC 1686 chromosome, complete genomeamidohydrolase family protein3e-1273.2
NC_007760:645016:6618616618616632581398Anaeromyxobacter dehalogenans 2CP-C, complete genomeformiminoglutamate deiminase5e-1272.8
NC_014221:3068222:3092661309266130939801320Truepera radiovictrix DSM 17093 chromosome, complete genomeguanine deaminase1e-1171.6
NC_016514:1627664:1645676164567616469951320Enterobacter cloacae EcWSU1 chromosome, complete genomeGuanine deaminase2e-1170.9
NC_020209:47504:8800588005894021398Pseudomonas poae RE*1-1-14, complete genomeS-adenosylhomocysteine deaminase2e-1170.9
NC_008314:477722:4909104909104923311422Ralstonia eutropha H16 chromosome 2, complete sequencecytosine deaminase or related metal-dependent hydrolase6e-1168.9
NC_021182:1077721:1078725107872510800051281Clostridium pasteurianum BC1, complete genomeguanine deaminase1e-1068.2
NC_015580:1328361:1338694133869413401661473Novosphingobium sp. PP1Y, complete genomecytosine deaminase and related metal-dependent hydrolases4e-1066.2
NC_014328:2643588:2645078264507826463611284Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeguanine deaminase8e-1065.5
NC_008148:3024867:3044409304440930459081500Rubrobacter xylanophilus DSM 9941, complete genomeamidohydrolase1e-0964.7
NC_015968:1618862:1638360163836016396761317Enterobacter asburiae LF7a chromosome, complete genomeguanine deaminase2e-0964.3
NC_013406:1217385:1274597127459712759611365Paenibacillus sp. Y412MC10 chromosome, complete genomeguanine deaminase3e-0963.5
NC_014100:1144463:1166595116659511678871293Caulobacter segnis ATCC 21756 chromosome, complete genomeguanine deaminase9e-0962
NC_009635:1067334:1081542108154210827201179Methanococcus aeolicus Nankai-3 chromosome, complete genomechlorohydrolase5e-0859.7