Pre_GI: BLASTP Hits

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Query: NC_010674:615963:624336 Clostridium botulinum B str. Eklund 17B, complete genome

Start: 624336, End: 625544, Length: 1209

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum B str. Eklund 17B is a nonproteolytic botulism neurotoxin B strain. This strain was isolated from marine sediments taken off the coast of Washington, USA and was not associated with botulism. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010723:575254:5884415884415896491209Clostridium botulinum E3 str. Alaska E43, complete genomediaminopropionate ammonia-lyase0796
NC_013315:2232339:2246673224667322478871215Clostridium difficile CD196 chromosome, complete genomediaminopropionate ammonia-lyase2e-165582
NC_013316:2309694:2327227232722723284411215Clostridium difficile R20291, complete genomediaminopropionate ammonia-lyase2e-165582
NC_017179:3540739:3556679355667935578931215Clostridium difficile BI1, complete genomediaminopropionate ammonia-lyase8e-165580
NC_013315:3532721:3548661354866135498751215Clostridium difficile CD196 chromosome, complete genomediaminopropionate ammonia-lyase8e-165580
NC_017243:2190000:2221022222102222222151194Brachyspira intermedia PWS/A chromosome, complete genomediaminopropionate ammonia-lyase2e-143509
NC_012225:47800:7087570875720681194Brachyspira hyodysenteriae WA1, complete genomediaminopropionate ammonia-lyase2e-142505
NC_019908:2401577:2417563241756324187561194Brachyspira pilosicoli P43/6/78 chromosome, complete genomediaminopropionate ammonia-lyase3e-141501
NC_014330:768232:8023458023458035381194Brachyspira pilosicoli 95/1000 chromosome, complete genomediaminopropionate ammonia-lyase DpaL3e-141501
NC_018604:2253539:2265135226513522663281194Brachyspira pilosicoli WesB complete genomediaminopropionate ammonia-lyase DpaL3e-141501
NC_021182:401129:4124084124084136341227Clostridium pasteurianum BC1, complete genomediaminopropionate ammonia-lyase7e-141500
NC_014150:2994000:3007634300763430088271194Brachyspira murdochii DSM 12563 chromosome, complete genomediaminopropionate ammonia-lyase7e-139494
NC_011294:1006630:1009010100901010102241215Salmonella enterica subsp. enterica serovar Enteritidis strdiaminopropionate ammonia-lyase3e-123442
NC_019978:1022209:1027061102706110282901230Halobacteroides halobius DSM 5150, complete genomediaminopropionate ammonia-lyase7e-117421
NC_016642:1234500:1234792123479212360391248Pseudovibrio sp. FO-BEG1 chromosome, complete genomeDiaminopropionate ammonia-lyase1e-109397
NC_007384:3151344:3177205317720531784011197Shigella sonnei Ss046, complete genomeputative dehydratase2e-106386
NC_002695:3702344:3745841374584137470371197Escherichia coli O157:H7 str. Sakai, complete genomediaminopropionate ammonia-lyase2e-105383
NC_000913:2975659:3005532300553230067281197Escherichia coli K12, complete genomediaminopropionate ammonia-lyase2e-105383
NC_011751:3285646:3330070333007033312661197Escherichia coli UMN026 chromosome, complete genomediaminopropionate ammonia-lyase2e-105383
AC_000091:2976293:3006166300616630073621197Escherichia coli W3110 DNA, complete genome2,3-diaminopropionate ammonia-lyase2e-105383
CP002185:3167738:3204559320455932057551197Escherichia coli W, complete genome2,3-diaminopropionate ammonia-lyase2e-105383
CU928160:3030324:3065766306576630669621197Escherichia coli IAI1 chromosome, complete genome2,3-diaminopropionate ammonia-lyase2e-105383
NC_010473:3069529:3099402309940231005981197Escherichia coli str. K-12 substr. DH10B, complete genome2,3-diaminopropionate ammonia-lyase2e-105383
CU928145:3196173:3231651323165132328471197Escherichia coli 55989 chromosome, complete genome2,3-diaminopropionate ammonia-lyase2e-105383
NC_011750:3407500:3434796343479634359921197Escherichia coli IAI39 chromosome, complete genomediaminopropionate ammonia-lyase2e-105383
NC_011748:3196173:3231651323165132328471197Escherichia coli 55989, complete genomediaminopropionate ammonia-lyase2e-105383
NC_011353:3805819:3850238385023838514341197Escherichia coli O157:H7 str. EC4115 chromosome, complete genomediaminopropionate ammonia-lyase2e-105383
NC_011415:3217796:3253236325323632544321197Escherichia coli SE11 chromosome, complete genomediaminopropionate ammonia-lyase2e-105383
NC_011741:3030324:3065766306576630669621197Escherichia coli IAI1 chromosome, complete genomediaminopropionate ammonia-lyase2e-105383
NC_012759:2862807:2892680289268028938761197Escherichia coli BW2952 chromosome, complete genomediaminopropionate ammonia-lyase2e-105383
NC_013008:3761467:3804964380496438061601197Escherichia coli O157:H7 str. TW14359 chromosome, complete genomediaminopropionate ammonia-lyase2e-105383
NC_013364:3552284:3587735358773535889311197Escherichia coli O111:H- str. 11128, complete genome2,3-diaminopropionate ammonia-lyase2e-105383
NC_013941:3540420:3569845356984535710411197Escherichia coli O55:H7 str. CB9615 chromosome, complete genomediaminopropionate ammonia-lyase2e-105383
NC_002655:3769643:3813147381314738143431197Escherichia coli O157:H7 EDL933, complete genomediaminopropionate ammonia-lyase1e-105383
NC_020272:3396800:3422476342247634236721197Bacillus amyloliquefaciens IT-45, complete genomediaminopropionate ammonia-lyase5e-103374
NC_011894:5751417:5773052577305257742451194Methylobacterium nodulans ORS 2060, complete genomediaminopropionate ammonia-lyase1e-68260
NC_008578:1827605:1837635183763518388431209Acidothermus cellulolyticus 11B, complete genomePyridoxal-5'-phosphate-dependent enzyme, beta subunit1e-62240
NC_007205:1232734:1251973125197312531151143Candidatus Pelagibacter ubique HTCC1062, complete genomediaminopropionate ammonia-lyase2e-57223
NC_008148:3024867:3029834302983430310241191Rubrobacter xylanophilus DSM 9941, complete genomePyridoxal-5'-phosphate-dependent enzyme, beta subunit4e-56219
NC_016614:1152500:1153722115372211549091188Vibrio sp. EJY3 chromosome 2, complete sequencediaminopropionate ammonia-lyase1e-52207
NC_012527:288207:3046123046123057601149Deinococcus deserti VCD115 plasmid 1, complete sequencediaminopropionate ammonia-lyase2e-51203
NC_008392:1029134:1052569105256910537951227Burkholderia cepacia AMMD chromosome 3, complete sequenceDiaminopropionate ammonia-lyase4e-51202
NC_010557:679656:7209977209977222231227Burkholderia ambifaria MC40-6 chromosome 3, complete sequenceDiaminopropionate ammonia-lyase1e-50200
NC_009142:5425763:5443600544360054447571158Saccharopolyspora erythraea NRRL 2338, complete genomepyridoxal-5'-phosphate-dependent enzyme, beta subunit7e-50198
NC_018643:857911:8787698787698799201152Alpha proteobacterium HIMB5 chromosome, complete genomePyridoxal-phosphate dependent enzyme2e-45183
NC_007948:1972290:197429419742941974911618Polaromonas sp. JS666, complete genome6e-25115
NC_006177:3457637:3457637345763734588691233Symbiobacterium thermophilum IAM 14863, complete genomethreonine dehydratase4e-1376.3
NC_008025:1889891:1910418191041819119621545Deinococcus geothermalis DSM 11300, complete genomethreonine dehydratase, biosynthetic2e-1170.9
NC_014759:1957979:1964634196463419658991266Marivirga tractuosa DSM 4126 chromosome, complete genomethreonine dehydratase7e-1168.6
NC_011979:773673:7736737736737748811209Geobacter sp. FRC-32, complete genomethreonine dehydratase3e-1066.6
NC_015144:47783:7724077240784841245Weeksella virosa DSM 16922 chromosome, complete genomethreonine dehydratase4e-0962.8
NC_016002:1765959:1776645177664517781741530Pseudogulbenkiania sp. NH8B, complete genomethreonine dehydratase, biosynthetic5e-0962.4
NC_013192:1824174:1833585183358518348021218Leptotrichia buccalis DSM 1135, complete genomethreonine dehydratase2e-0860.8
NC_005042:830000:8422408422408437811542Prochlorococcus marinus subsp. marinus str. CCMP1375, completethreonine dehydratase2e-0860.8
NC_018000:1877183:1888220188822018892331014Sinorhizobium fredii USDA 257 chromosome, complete genomephenylserine dehydratase3e-0860.1
NC_002952:1497785:1538429153842915394691041Staphylococcus aureus subsp. aureus MRSA252, complete genomethreonine dehydratase3e-0860.1
NC_007795:1370500:1407997140799714090371041Staphylococcus aureus subsp. aureus NCTC 8325, complete genomethreonine dehydratase3e-0860.1
NC_002951:1474465:1514662151466215157021041Staphylococcus aureus subsp. aureus COL, complete genomethreonine dehydratase3e-0860.1
NC_007793:1451409:1491375149137514924151041Staphylococcus aureus subsp. aureus USA300, complete genomethreonine dehydratase3e-0860.1
NC_002953:1464693:1500259150025915012991041Staphylococcus aureus subsp. aureus MSSA476, complete genomethreonine dehydratase3e-0860.1
NC_003923:1436139:1474553147455314755931041Staphylococcus aureus subsp. aureus MW2, complete genomethreonine dehydratase3e-0860.1
NC_010079:1465356:1505322150532215063621041Staphylococcus aureus subsp. aureus USA300_TCH1516, completethreonine ammonia-lyase3e-0860.1
NC_009641:1470500:1510842151084215118821041Staphylococcus aureus subsp. aureus str. Newman chromosome,threonine dehydratase3e-0860.1
NC_016912:1374351:1411659141165914126991041Staphylococcus aureus subsp. aureus VC40 chromosome, completethreonine dehydratase3e-0860.1
NC_016928:1440319:1480363148036314814031041Staphylococcus aureus subsp. aureus M013 chromosome, completeThreonine dehydratase, catabolic3e-0860.1
NC_017337:1478448:1516070151607015171101041Staphylococcus aureus subsp. aureus ED133 chromosome, completethreonine dehydratase3e-0860.1
NC_017341:1482882:1522843152284315238831041Staphylococcus aureus subsp. aureus str. JKD6008 chromosome,threonine dehydratase3e-0860.1
NC_017347:1483163:1523124152312415241641041Staphylococcus aureus subsp. aureus T0131 chromosome, completeThreonine dehydratase catabolic3e-0860.1
NC_017351:1464209:1504610150461015056501041Staphylococcus aureus subsp. aureus 11819-97 chromosome, completethreonine dehydratase3e-0860.1
NC_008528:610070:6213536213536227741422Oenococcus oeni PSU-1, complete genomeThreonine dehydratase4e-0859.7
NC_017093:835260:8542838542838555421260Actinoplanes missouriensis 431, complete genomeputative threonine dehydratase4e-0859.7
NC_008571:2229369:2237475223747522387491275Gramella forsetii KT0803, complete genomethreonine dehydratase biosynthetic5e-0859.3
NC_007760:3948730:3964874396487439660851212Anaeromyxobacter dehalogenans 2CP-C, complete genomethreonine dehydratase4e-0756.2
NC_009782:1510396:1550912155091215519521041Staphylococcus aureus subsp. aureus Mu3, complete genomethreonine deaminase IlvA homolog4e-0756.2
NC_002745:1432585:1473100147310014741401041Staphylococcus aureus subsp. aureus N315, complete genomethreonine dehydratase4e-0756.2
NC_002758:1508996:1549512154951215505521041Staphylococcus aureus subsp. aureus Mu50, complete genomethreonine dehydratase4e-0756.2
NC_009487:1557248:1597880159788015989201041Staphylococcus aureus subsp. aureus JH9 chromosome, completethreonine dehydratase4e-0756.2
NC_009632:1557122:1597754159775415987941041Staphylococcus aureus subsp. aureus JH1 chromosome, completethreonine dehydratase4e-0756.2
NC_013450:1446952:1487348148734814883881041Staphylococcus aureus subsp. aureus ED98, complete genomethreonine dehydratase4e-0756.2
NC_017343:1391124:1431640143164014326801041Staphylococcus aureus subsp. aureus ECT-R 2, complete genomethreonine dehydratase4e-0756.2
NC_017338:1419500:1459537145953714605771041Staphylococcus aureus subsp. aureus JKD6159 chromosome, completethreonine dehydratase, IlvA4e-0756.2
NC_013517:104480:1101891101891113941206Sebaldella termitidis ATCC 33386, complete genomethreonine dehydratase5e-0755.8
NC_016582:5393568:5394666539466653958651200Streptomyces bingchenggensis BCW-1 chromosome, complete genomethreonine dehydratase5e-0755.8
NC_019974:3013338:3022611302261130238641254Natronococcus occultus SP4, complete genomethreonine dehydratase, medium form5e-0755.8
NC_011146:4196652:4215249421524942164571209Geobacter bemidjiensis Bem, complete genomethreonine dehydratase5e-0755.8
NC_005061:647567:6570996570996586431545Candidatus Blochmannia floridanus, complete genomethreonine dehydratase7e-0755.5
NC_015957:1070500:1093874109387410953161443Streptomyces violaceusniger Tu 4113 chromosome, complete genomethreonine dehydratase7e-0755.5
NC_009464:2687445:2724547272454727257881242Uncultured methanogenic archaeon RC-I, complete genomethreonine synthase7e-0755.5
NC_014471:1269571:1295882129588212971141233Ignisphaera aggregans DSM 17230 chromosome, complete genomethreonine dehydratase6e-0755.5
NC_009255:2044291:2065467206546720669901524Burkholderia vietnamiensis G4 chromosome 2, complete sequenceL-threonine ammonia-lyase9e-0755.1
NC_016941:1411500:1435636143563614366761041Staphylococcus aureus subsp. aureus MSHR1132, complete genomecatabolic threonine dehydratase9e-0755.1
NC_014221:3068222:309087630908763091868993Truepera radiovictrix DSM 17093 chromosome, complete genomePyridoxal-5'-phosphate-dependent protein beta subunit9e-0755.1
NC_009831:5107924:5116129511612951176791551Shewanella sediminis HAW-EB3, complete genomethreonine dehydratase, biosynthetic1e-0654.7
NC_009481:1109324:1112425111242511139571533Synechococcus sp. WH 7803 chromosome, complete genomethreonine dehydratase1e-0654.7
NC_009512:5632591:5683202568320256847161515Pseudomonas putida F1, complete genomethreonine dehydratase, biosynthetic3e-0653.5
NC_009053:1668500:1668513166851316700391527Actinobacillus pleuropneumoniae L20, complete genomethreonine dehydratase biosynthetic3e-0653.5
NC_010278:1625695:1625695162569516272211527Actinobacillus pleuropneumoniae serovar 3 str. JL03 chromosome,threonine dehydratase3e-0653.5
NC_010170:1661915:1665364166536416665811218Bordetella petrii, complete genomethreonine dehydratase catabolic3e-0653.5
NC_014909:662500:6716446716446731761533Candidatus Blochmannia vafer str. BVAF chromosome, complete genomethreonine dehydratase, biosynthetic2e-0653.5
NC_020410:2068500:2091978209197820932461269Bacillus amyloliquefaciens subsp. plantarum UCMB5036 completethreonine dehydratase3e-0653.1
NC_009725:2072475:2099168209916821004361269Bacillus amyloliquefaciens FZB42, complete genomeIlvA3e-0653.1
NC_015666:1293500:1297178129717812983891212Halopiger xanaduensis SH-6 chromosome, complete genomethreonine dehydratase3e-0653.1
NC_019842:2134803:2157191215719121584591269Bacillus amyloliquefaciens subsp. plantarum AS43.3 chromosome,threonine dehydratase3e-0653.1
NC_008698:560529:5639355639355651611227Thermofilum pendens Hrk 5, complete genomethreonine dehydratase3e-0653.1
NC_013406:1145268:1146318114631811475861269Paenibacillus sp. Y412MC10 chromosome, complete genomethreonine dehydratase5e-0652.8
NC_016779:1688946:1706503170650317077651263Bacillus cereus F837/76 chromosome, complete genomeThreonine dehydratase, biosynthetic5e-0652.8
NC_011969:1816746:1830978183097818321801203Bacillus cereus Q1 chromosome, complete genomethreonine dehydratase5e-0652.4
NC_019892:5368096:538660053866005387559960Singulisphaera acidiphila DSM 18658 chromosome, complete genomethreonine dehydratase6e-0652.4
NC_009484:2442923:246520424652042466130927Acidiphilium cryptum JF-5 chromosome, complete genomethreonine dehydratase7e-0652
NC_003413:37233:383333833339247915Pyrococcus furiosus DSM 3638, complete genomethreonine synthase8e-0652