Pre_GI: BLASTP Hits

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Query: NC_010674:3674739:3710863 Clostridium botulinum B str. Eklund 17B, complete genome

Start: 3710863, End: 3711762, Length: 900

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum B str. Eklund 17B is a nonproteolytic botulism neurotoxin B strain. This strain was isolated from marine sediments taken off the coast of Washington, USA and was not associated with botulism. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010723:3530000:356788935678893568788900Clostridium botulinum E3 str. Alaska E43, complete genomephospholipase, patatin family2e-170597
NC_008262:1721496:173346217334621734379918Clostridium perfringens SM101, complete genomePatatin-like phospholipase family1e-71270
NC_017243:1197586:120433112043311205104774Brachyspira intermedia PWS/A chromosome, complete genomePatatin-like phospholipase family protein2e-35149
NC_015519:245036:2460972460972473171221Tepidanaerobacter sp. Re1 chromosome, complete genomePatatin6e-28124
NC_009255:351695:3561883561883572641077Burkholderia vietnamiensis G4 chromosome 2, complete sequencepatatin4e-26118
NC_010376:186510:232561232561233346786Finegoldia magna ATCC 29328, complete genomehypothetical protein8e-24111
NC_012912:4167429:4173238417323841743111074Dickeya zeae Ech1591, complete genomePatatin6e-24111
NC_016822:3420826:3438364343836434394341071Shigella sonnei 53G, complete genomehypothetical protein4e-22105
NC_014624:3538094:3549229354922935506921464Eubacterium limosum KIST612 chromosome, complete genomepatatin3e-21102
NC_009714:292470:309385309385310242858Campylobacter hominis ATCC BAA-381, complete genomepatatin family phospholipase9e-1994.4
NC_014393:2905248:2918501291850129196701170Clostridium cellulovorans 743B chromosome, complete genomePatatin4e-1892.4
NC_014366:1663034:1672101167210116731471047Gamma proteobacterium HdN1, complete genomehypothetical protein2e-1789.7
NC_016745:2785346:2811461281146128126151155Oceanimonas sp. GK1 chromosome, complete genomepatatin4e-1272.4
NC_010814:3048441:309185130918513092798948Geobacter lovleyi SZ, complete genomePatatin2e-1170.5
NC_013850:2103469:210492521049252105827903Klebsiella variicola At-22 chromosome, complete genomePatatin2e-1169.7
NC_016609:7659853:767457676745767675349774Niastella koreensis GR20-10 chromosome, complete genomepatatin3e-1169.3
NC_008321:1523323:1557276155727615584001125Shewanella sp. MR-4, complete genomePatatin3e-1169.3
NC_015968:2583721:259925325992532600155903Enterobacter asburiae LF7a chromosome, complete genomePatatin4e-1168.9
NC_008750:1659095:1680300168030016814241125Shewanella sp. W3-18-1, complete genomePatatin7e-1168.2
NC_016514:2647984:266371826637182664662945Enterobacter cloacae EcWSU1 chromosome, complete genomeNTE family protein rssA4e-1065.9
NC_011884:2921618:294128729412872942228942Cyanothece sp. PCC 7425, complete genomePatatin5e-1065.5
NC_014121:1653385:165485016548501655752903Enterobacter cloacae subsp. cloacae ATCC 13047 chromosome, completehypothetical protein8e-1064.7
NC_020133:5020500:5033039503303950341031065Mycobacterium liflandii 128FXT, complete genomeEsterase of the alpha-beta hydrolase superfamily2e-0963.5
NC_010612:5403000:5415413541541354164771065Mycobacterium marinum M, complete genomehypothetical protein2e-0963.2
NC_002488:45219:5938759387605741188Xylella fastidiosa 9a5c, complete genomehypothetical protein6e-0961.6
NC_017516:2220000:222159322215932222495903Neisseria meningitidis H44/76 chromosome, complete genomephospholipase, patatin family8e-0961.2
NC_008767:2160000:216165621616562162558903Neisseria meningitidis FAM18, complete genomepossible lipoprotein8e-0961.2
NC_010511:871905:9066979066979077401044Methylobacterium sp. 4-46 chromosome, complete genomepatatin2e-0860.1
NC_010513:44886:5866358663597031041Xylella fastidiosa M12 chromosome, complete genomelipoprotein2e-0860.1
NC_011969:3657360:368036636803663681157792Bacillus cereus Q1 chromosome, complete genomephospholipase5e-0858.5
NC_015563:3511951:3513625351362535146651041Delftia sp. Cs1-4 chromosome, complete genomePatatin5e-0858.5
NC_017511:1812000:181332918133291814231903Neisseria gonorrhoeae TCDC-NG08107 chromosome, complete genomehypothetical protein2e-0757
NC_011035:1908000:190948519094851910387903Neisseria gonorrhoeae NCCP11945 chromosome, complete genomePossible lipoprotein2e-0757
NC_002946:1902642:192225019222501923152903Neisseria gonorrhoeae FA 1090, complete genomehypothetical protein2e-0757
NC_011297:767333:769312769312770244933Dictyoglomus thermophilum H-6-12, complete genomeesterase2e-0757
NC_006371:1411335:1411335141133514135632229Photobacterium profundum SS9 chromosome 2, complete sequencehypothetical protein2e-0756.6
NC_004557:806878:826235826235827086852Clostridium tetani E88, complete genomeconserved protein with patatin domain2e-0756.6
NC_016931:773871:7874917874917892871797Rickettsia massiliae str. AZT80 chromosome, complete genomeputative esterase of the alpha/beta hydrolase superfamily protein4e-0755.5
NC_015638:923660:9355469355469377892244Lacinutrix sp. 5H-3-7-4 chromosome, complete genomePatatin8e-0754.7
NC_011661:938754:940730940730941662933Dictyoglomus turgidum DSM 6724, complete genomePatatin3e-0652.8