Pre_GI: BLASTP Hits

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Query: NC_010674:3049500:3054849 Clostridium botulinum B str. Eklund 17B, complete genome

Start: 3054849, End: 3055256, Length: 408

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum B str. Eklund 17B is a nonproteolytic botulism neurotoxin B strain. This strain was isolated from marine sediments taken off the coast of Washington, USA and was not associated with botulism. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010723:2873886:287824628782462878653408Clostridium botulinum E3 str. Alaska E43, complete genomecytidine deaminase5e-72269
NC_020291:1810527:182505618250561825454399Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomecytidine deaminase Cdd2e-53207
NC_014393:1782811:178368717836871784085399Clostridium cellulovorans 743B chromosome, complete genomecytidine deaminase1e-40164
NC_017297:3178378:317837831783783178776399Clostridium botulinum F str. 230613 chromosome, complete genomecytidine deaminase2e-40164
NC_009699:3178222:317822231782223178620399Clostridium botulinum F str. Langeland chromosome, complete genomecytidine deaminase2e-40164
NC_009698:3006500:300763830076383008036399Clostridium botulinum A str. Hall chromosome, complete genomecytidine deaminase2e-40164
NC_009633:3055413:305973530597353060136402Alkaliphilus metalliredigens QYMF chromosome, complete genomecytidine deaminase4e-38156
NC_012472:4119192:412009041200904120488399Bacillus cereus 03BB102, complete genomecytidine deaminase1e-31135
NC_008600:4101748:410264641026464103044399Bacillus thuringiensis str. Al Hakam, complete genomecytidine deaminase1e-31135
NC_019970:2263427:227816422781642278565402Thermoanaerobacterium thermosaccharolyticum M0795, complete genomecytidine deaminase, homotetrameric1e-31134
NC_016771:4059445:406218340621834062581399Bacillus cereus NC7401, complete genomecytidine deaminase3e-31133
NC_011969:4001489:400348740034874003885399Bacillus cereus Q1 chromosome, complete genomecytidine deaminase3e-31133
NC_011658:4107501:410839941083994108797399Bacillus cereus AH187 chromosome, complete genomecytidine deaminase3e-31133
NC_015555:1989463:200622820062282006623396Thermoanaerobacterium xylanolyticum LX-11 chromosome, completecytidine deaminase9e-31132
NC_011898:649000:670090670090670479390Clostridium cellulolyticum H10, complete genomecytidine deaminase4e-30129
NC_016627:1960097:196739019673901967806417Clostridium clariflavum DSM 19732 chromosome, complete genomecytidine deaminase3e-29127
NC_009012:1901492:191215619121561912572417Clostridium thermocellum ATCC 27405, complete genomecytidine deaminase2e-29127
NC_008054:1030994:106110010611001061519420Lactobacillus delbrueckii subsp. bulgaricus ATCC 11842, completeCytidine deaminase9e-29125
NC_008529:1042220:107941710794171079836420Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365, completeCytidine deaminase9e-29125
NC_013171:342714:375056375056375451396Anaerococcus prevotii DSM 20548, complete genomecytidine deaminase2e-28124
NC_016751:1227495:123816512381651238590426Marinitoga piezophila KA3 chromosome, complete genomecytidine deaminase3e-27120
NC_015500:1923514:196393019639301964337408Treponema brennaborense DSM 12168 chromosome, complete genomecytidine deaminase4e-27120
NC_011661:1332309:134439213443921344787396Dictyoglomus turgidum DSM 6724, complete genomecytidine deaminase5e-27119
NC_016070:1657500:166133116613311661723393Thermoproteus tenax Kra 1, complete genomeCytidine deaminase5e-26116
NC_016885:2091918:212987721298772130260384Pyrobaculum oguniense TE7 chromosome, complete genomecytidine deaminase1e-25115
NC_016645:1838405:188773118877311888117387Pyrobaculum sp. 1860 chromosome, complete genomecytidine deaminase3e-25114
NC_013198:1538792:156800615680061568395390Lactobacillus rhamnosus GG, complete genomeCytidine deaminase, homotetrameric2e-24111
NC_014833:97931:113332113332113715384Ruminococcus albus 7 chromosome, complete genomecytidine deaminase3e-24110
NC_009073:1:666166617044384Pyrobaculum calidifontis JCM 11548, complete genomecytidine deaminase3e-24110
NC_009617:3647500:365881636588163659217402Clostridium beijerinckii NCIMB 8052 chromosome, complete genomecytidine deaminase1e-23108
NC_007503:1383255:138913313891331389531399Carboxydothermus hydrogenoformans Z-2901, complete genomecytidine deaminase1e-23108
NC_014961:335808:338986338986339405420Desulfurococcus mucosus DSM 2162 chromosome, complete genomecytidine deaminase2e-23107
NC_015435:21736:231562315623563408Metallosphaera cuprina Ar-4 chromosome, complete genomecytidine deaminase7e-22102
NC_015518:685885:708349708349708744396Acidianus hospitalis W1 chromosome, complete genomecytidine deaminase8e-22102
NC_015578:2428500:245091524509152451313399Treponema primitia ZAS-2 chromosome, complete genomecytidine deaminase2e-21101
NC_012704:1641684:165562916556291656081453Corynebacterium kroppenstedtii DSM 44385, complete genomeCytidine deaminase2e-21100
NC_011979:646518:654645654645655058414Geobacter sp. FRC-32, complete genomecytidine deaminase2e-21100
NC_013517:1916020:193103419310341931435402Sebaldella termitidis ATCC 33386, complete genomecytidine deaminase5e-2199.8
NC_011999:1320159:132324313232431323647405Macrococcus caseolyticus JCSC5402, complete genomecytidine deaminase homolog1e-2098.2
NC_020291:5093138:511007151100715110472402Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomecytidine deaminase Cdd2e-2098.2
NC_015387:1091403:110706311070631107449387Marinithermus hydrothermalis DSM 14884 chromosome, complete genomecytidine deaminase2e-1994.4
NC_009440:21947:233772337723781405Metallosphaera sedula DSM 5348 chromosome, complete genomecytidine deaminase3e-1993.6
NC_015942:668775:677918677918678364447Acidithiobacillus ferrivorans SS3 chromosome, complete genomecytidine deaminase8e-1992.4
NC_011896:2571232:258607225860722586476405Mycobacterium leprae Br4923, complete genomecytidine deaminase7e-1889.4
NC_002677:2571310:258614125861412586545405Mycobacterium leprae TN, complete genomecytidine deaminase7e-1889.4
NC_015638:1914000:191942519194251919973549Lacinutrix sp. 5H-3-7-4 chromosome, complete genomecytidine deaminase7e-1889
NC_006055:140686:157796157796158203408Mesoplasma florum L1, complete genomecytidine deaminase3e-1787.4
NC_002162:643446:660442660442660837396Ureaplasma parvum serovar 3 str. ATCC 700970, complete genomecytidine deaminase4e-1786.7
NC_015064:1238899:125207212520721252494423Acidobacterium sp. MP5ACTX9 chromosome, complete genomecytidine deaminase6e-1786.3
NC_020133:1443934:146215014621501462548399Mycobacterium liflandii 128FXT, complete genomecytidine deaminase Cdd6e-1786.3
NC_007622:1558753:155875315587531559157405Staphylococcus aureus RF122, complete genomecytidine deaminase6e-1786.3
NC_008710:621822:649244649244649699456Borrelia turicatae 91E135, complete genomecytidine deaminase5e-1683.2
NC_013169:805124:806455806455806886432Kytococcus sedentarius DSM 20547, complete genomecytidine deaminase1e-1581.6
NC_015144:1576047:157978015797801580256477Weeksella virosa DSM 16922 chromosome, complete genomeCMP/dCMP deaminase zinc-binding protein1e-1581.6
NC_015510:8069440:807172880717288072201474Haliscomenobacter hydrossis DSM 1100 chromosome, complete genomecytidine deaminase1e-1581.6
NC_017075:4880807:488286848828684883287420Rubrivivax gelatinosus IL144, complete genomecytidine deaminase Cdd3e-1270.5
NC_013501:1547508:156640215664021567190789Rhodothermus marinus DSM 4252, complete genomeCMP/dCMP deaminase zinc-binding protein4e-1166.6
NC_010334:2131939:213352721335272134417891Shewanella halifaxensis HAW-EB4, complete genomeCytidine deaminase3e-0753.9
NC_015424:2316228:234913023491302350014885Aeromonas veronii B565 chromosome, complete genomeCytidine deaminase1e-0651.6
NC_015572:65597:765437654377010468Methylomonas methanica MC09 chromosome, complete genomeCMP/dCMP deaminase zinc-binding protein3e-0650.4