Pre_GI: BLASTP Hits

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Query: NC_010674:3049500:3051618 Clostridium botulinum B str. Eklund 17B, complete genome

Start: 3051618, End: 3052508, Length: 891

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum B str. Eklund 17B is a nonproteolytic botulism neurotoxin B strain. This strain was isolated from marine sediments taken off the coast of Washington, USA and was not associated with botulism. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010723:2873886:287480628748062875696891Clostridium botulinum E3 str. Alaska E43, complete genomehypothetical protein1e-108393
NC_008942:815280:816477816477817328852Methanocorpusculum labreanum Z, complete genomehypothetical protein6e-52204
NC_017341:903473:919636919636920487852Staphylococcus aureus subsp. aureus str. JKD6008 chromosome,integral membrane protein4e-1892
NC_004193:375416:619786619786620601816Oceanobacillus iheyensis HTE831, complete genomehypothetical protein2e-1583.2
NC_017208:5124333:512433351243335125139807Bacillus thuringiensis serovar chinensis CT-43 chromosome, completeintegral membrane protein6e-1581.6
NC_011772:5021404:502140450214045022210807Bacillus cereus G9842, complete genomehypothetical protein6e-1581.6
NC_010184:4909183:491075949107594911565807Bacillus weihenstephanensis KBAB4, complete genomeprotein of unknown function DUF3687e-1581.3
NC_011658:4904156:490574549057454906551807Bacillus cereus AH187 chromosome, complete genomehypothetical protein1e-1480.9
NC_003997:4876415:487641548764154877221807Bacillus anthracis str. Ames, complete genomehypothetical protein9e-1580.9
NC_005945:4877752:487775248777524878558807Bacillus anthracis str. Sterne, complete genomehypothetical protein9e-1580.9
NC_020409:329915:331164331164332150987Desulfovibrio piezophilus str. nov C1TLV30 chromosome, completeconserved membrane protein of unknown function2e-1273.2
NC_003450:1395565:139855413985541399534981Corynebacterium glutamicum ATCC 13032, complete genomehypothetical protein3e-1272.4
NC_006958:1396264:140002114000211401001981Corynebacterium glutamicum ATCC 13032, complete genomehypothetical protein3e-1272.4
NC_009342:1538000:154224315422431543223981Corynebacterium glutamicum R chromosome, complete genomehypothetical protein4e-1272.4
NC_016782:1076619:107661910766191077551933Corynebacterium diphtheriae 241 chromosome, complete genomehypothetical protein2e-1169.7
NC_013967:1375255:140047014004701401438969Haloferax volcanii DS2 chromosome, complete genomepredicted membrane protein9e-0857.8
NC_007681:696252:698684698684699544861Methanosphaera stadtmanae DSM 3091, complete genomeconserved hypothetical membrane-spanning protein3e-0755.8
NC_014210:723719:743030743030743959930Nocardiopsis dassonvillei subsp. dassonvillei DSM 43111 chromosome,protein of unknown function DUF3685e-0652