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Query: NC_010674:2435241:2447956 Clostridium botulinum B str. Eklund 17B, complete genome

Start: 2447956, End: 2449020, Length: 1065

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum B str. Eklund 17B is a nonproteolytic botulism neurotoxin B strain. This strain was isolated from marine sediments taken off the coast of Washington, USA and was not associated with botulism. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010723:2231834:2245939224593922470031065Clostridium botulinum E3 str. Alaska E43, complete genomesugar diacid utilization regulator2e-178624
NC_015565:824448:8333528333528345121161Desulfotomaculum carboxydivorans CO-1-SRB chromosome, completetranscriptional regulator CdaR7e-35148
NC_014328:3120145:3124197312419731253481152Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeputative sugar diacid regulator6e-27121
NC_011184:2421687:2421687242168724228321146Vibrio fischeri MJ11 chromosome I, complete sequencecarbohydrate diacid regulator3e-26119
NC_012912:1200000:1201702120170212028591158Dickeya zeae Ech1591, complete genometranscriptional regulator, CdaR3e-25116
NC_020207:1346579:1378628137862813796411014Enterococcus faecium NRRL B-2354, complete genomeSugar diacid utilization regulator SdaR8e-25114
NC_007644:2452244:2470892247089224720641173Moorella thermoacetica ATCC 39073, complete genometranscriptional regulator, CdaR1e-23111
NC_009848:3582384:3597045359704535981571113Bacillus pumilus SAFR-032, complete genomesugar diacid utilization regulator5e-23108
NC_006351:142788:1658761658761670961221Burkholderia pseudomallei K96243 chromosome 2, complete sequencetranscriptional regulator7e-23108
NC_007435:1981164:2004189200418920056551467Burkholderia pseudomallei 1710b chromosome II, complete sequenceputative transcriptional regulator2e-22107
NC_009078:142794:1656301656301670961467Burkholderia pseudomallei 1106a chromosome II, complete sequencecarbohydrate diacid regulator1e-22107
NC_012779:3570720:3588068358806835891891122Edwardsiella ictaluri 93-146, complete genomecarbohydrate diacid regulator3e-22106
NC_014364:4488875:4514838451483845159981161Spirochaeta smaragdinae DSM 11293 chromosome, complete genometranscriptional regulator, CdaR8e-1065.1
NC_013521:2924540:2927295292729529283771083Sanguibacter keddieii DSM 10542, complete genomesugar diacid utilization regulator4e-0962.4
NC_015690:1818333:1849573184957318508381266Paenibacillus mucilaginosus KNP414 chromosome, complete genomeputative transcriptional regulator4e-0962.4
NC_016935:2347691:2379588237958823807121125Paenibacillus mucilaginosus 3016 chromosome, complete genomeputative transcriptional regulator8e-0961.6
NC_009328:2378345:2405166240516624068481683Geobacillus thermodenitrificans NG80-2 chromosome, complete genomehypothetical protein1e-0654.3
NC_021171:1689518:1691766169176616936071842Bacillus sp. 1NLA3E, complete genomeputative transcriptional regulator7e-0652