Pre_GI: BLASTP Hits

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Query: NC_010674:2435241:2446534 Clostridium botulinum B str. Eklund 17B, complete genome

Start: 2446534, End: 2447790, Length: 1257

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum B str. Eklund 17B is a nonproteolytic botulism neurotoxin B strain. This strain was isolated from marine sediments taken off the coast of Washington, USA and was not associated with botulism. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010723:2231834:2244517224451722457731257Clostridium botulinum E3 str. Alaska E43, complete genomeGntP family permease0678
NC_015565:824448:8346778346778359481272Desulfotomaculum carboxydivorans CO-1-SRB chromosome, completeCitrate transporter1e-128460
NC_009848:3582384:3595656359565635969421287Bacillus pumilus SAFR-032, complete genomeGntP family gluconate:proton (H+) symporter2e-127456
NC_011184:2421687:2422960242296024242251266Vibrio fischeri MJ11 chromosome I, complete sequencegluconate permease3e-119428
NC_014632:11925:3266832668339181251Ilyobacter polytropus DSM 2926 chromosome, complete genomecitrate transporter1e-102373
NC_012779:3570720:358662935866293587585957Edwardsiella ictaluri 93-146, complete genomehypothetical protein1e-88327
NC_020207:1346579:1375395137539513766871293Enterococcus faecium NRRL B-2354, complete genomeD-glycerate transporter (predicted)3e-85315
NC_010003:570643:5872715872715886141344Petrotoga mobilis SJ95, complete genomegluconate transporter2e-0964.3
NC_004431:5123325:5144682514468251460251344Escherichia coli CFT073, complete genomeHigh-affinity gluconate transporter1e-0654.3
NC_016023:1874827:1884996188499618863421347Bacillus coagulans 36D1 chromosome, complete genomegluconate transporter1e-0654.3
AC_000091:4534935:4554633455463345559761344Escherichia coli W3110 DNA, complete genomefructuronate transporter3e-0653.5
NC_009801:4882684:4906902490690249082451344Escherichia coli E24377A, complete genomehigh-affinity gluconate transporter GntP3e-0653.5
NC_010498:4930649:4954576495457649559191344Escherichia coli SMS-3-5, complete genomehigh-affinity gluconate transporter GntP3e-0653.5
CP002185:4791811:4812394481239448137371344Escherichia coli W, complete genomefructuronate transporter3e-0653.5
CU928160:4570498:4610595461059546119381344Escherichia coli IAI1 chromosome, complete genomefructuronate transporter3e-0653.5
NC_000913:4528278:4547976454797645493191344Escherichia coli K12, complete genomefructuronate transporter3e-0653.5
NC_002695:5381576:5404775540477554061181344Escherichia coli O157:H7 str. Sakai, complete genomegluconate transport system permease 33e-0653.5
NC_016822:4889656:4911895491189549132381344Shigella sonnei 53G, complete genomefructuronate transporter3e-0653.5
NC_004741:4364235:4364235436423543655781344Shigella flexneri 2a str. 2457T, complete genomegluconate transport system permease 33e-0653.5
CP002516:4199133:4199133419913342004761344Escherichia coli KO11, complete genomegluconate transporter3e-0653.5
CP002797:4656327:4677849467784946791921344Escherichia coli NA114, complete genomeFructuronate transporter3e-0653.5
NC_020291:2291418:2297737229773722991311395Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomeH+/gluconate symporter family protein3e-0653.5
NC_011750:4978000:4997413499741349987561344Escherichia coli IAI39 chromosome, complete genomefructuronate transporter3e-0653.5
NC_016902:4199133:4199133419913342004761344Escherichia coli KO11FL chromosome, complete genomegluconate transporter3e-0653.5
NC_013941:5219841:5243056524305652443991344Escherichia coli O55:H7 str. CB9615 chromosome, complete genomeHigh-affinity gluconate transporter3e-0653.5
NC_013008:5411285:5434484543448454358271344Escherichia coli O157:H7 str. TW14359 chromosome, complete genomefructuronate transporter3e-0653.5
NC_012967:4510393:4530867453086745322101344Escherichia coli B str. REL606 chromosome, complete genomefructuronate transporter3e-0653.5
NC_011742:4873351:4892706489270648940491344Escherichia coli S88 chromosome, complete genomefructuronate transporter3e-0653.5
NC_011741:4570498:4610595461059546119381344Escherichia coli IAI1 chromosome, complete genomefructuronate transporter3e-0653.5
NC_011353:5455224:5478423547842354797661344Escherichia coli O157:H7 str. EC4115 chromosome, complete genomefructuronate transporter3e-0653.5
NC_020210:3341976:3367120336712033684901371Geobacillus sp. GHH01, complete genomegluconate transporter5e-0652.8
NC_013093:6511108:6511108651110865125021395Actinosynnema mirum DSM 43827, complete genomegluconate transporter5e-0652.8
NC_020064:521500:5235865235865249711386Serratia marcescens FGI94, complete genomegluconate transporter6e-0652.4
NC_017179:905347:9125869125869139261341Clostridium difficile BI1, complete genomepermease6e-0652.4
NC_013315:895500:9028099028099041491341Clostridium difficile CD196 chromosome, complete genomepermease6e-0652.4
NC_013316:891782:9004249004249017641341Clostridium difficile R20291, complete genomeputative permease6e-0652.4
NC_009089:965959:9731989731989745381341Clostridium difficile 630, complete genomeprobable permease6e-0652.4
NC_016941:2498299:2521380252138025227381359Staphylococcus aureus subsp. aureus MSHR1132, complete genomeputative gluconate permease7e-0652
NC_020210:2044944:2061065206106520623751311Geobacillus sp. GHH01, complete genomeputative permease8e-0652
NC_016928:2517691:2540118254011825414761359Staphylococcus aureus subsp. aureus M013 chromosome, completegluconate permease, Bsu4004-like protein8e-0652