Pre_GI: BLASTP Hits

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Query: NC_010674:2328307:2342527 Clostridium botulinum B str. Eklund 17B, complete genome

Start: 2342527, End: 2342832, Length: 306

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum B str. Eklund 17B is a nonproteolytic botulism neurotoxin B strain. This strain was isolated from marine sediments taken off the coast of Washington, USA and was not associated with botulism. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010723:2269372:227904822790482279377330Clostridium botulinum E3 str. Alaska E43, complete genomeGp6 protein3e-51200
NC_021182:338428:345951345951346265315Clostridium pasteurianum BC1, complete genomehypothetical protein4e-31133
NC_009253:2819000:282797228279722828280309Desulfotomaculum reducens MI-1 chromosome, complete genomehypothetical protein2e-1787.4
NC_011773:549500:550812550812551117306Bacillus cereus AH820 chromosome, complete genomeGp6 protein4e-1270.1
NC_014376:787460:823969823969824262294Clostridium saccharolyticum WM1 chromosome, complete genomehypothetical protein1e-0962
NC_012658:1405788:141793514179351418216282Clostridium botulinum Ba4 str. 657 chromosome, complete genomeGp6 protein1e-0652
NC_009697:3110772:312195931219593122258300Clostridium botulinum A str. ATCC 19397 chromosome, completehypothetical protein4e-0650.1