Pre_GI: BLASTP Hits

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Query: NC_010674:2328307:2341803 Clostridium botulinum B str. Eklund 17B, complete genome

Start: 2341803, End: 2342192, Length: 390

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum B str. Eklund 17B is a nonproteolytic botulism neurotoxin B strain. This strain was isolated from marine sediments taken off the coast of Washington, USA and was not associated with botulism. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010723:2269372:227834922783492278738390Clostridium botulinum E3 str. Alaska E43, complete genomehypothetical protein3e-70263
NC_021182:338428:346603346603346998396Clostridium pasteurianum BC1, complete genomehypothetical protein1e-37154
NC_014376:787460:824588824588824965378Clostridium saccharolyticum WM1 chromosome, complete genomeprophage pi2 protein 373e-1270.5
NC_010184:3464707:348632234863223486678357Bacillus weihenstephanensis KBAB4, complete genomeprophage pi2 protein 371e-0755.1
NC_014393:2868846:288323428832342883614381Clostridium cellulovorans 743B chromosome, complete genomephage related protein4e-0753.5
NC_007432:654904:685987685987686355369Streptococcus agalactiae A909, complete genomehypothetical protein5e-0753.1
NC_005945:3463199:347486534748653475221357Bacillus anthracis str. Sterne, complete genomehypothetical protein5e-0753.1
NC_003997:3462497:347416334741633474519357Bacillus anthracis str. Ames, complete genomehypothetical protein5e-0753.1
NC_007530:3462624:347429034742903474646357Bacillus anthracis str. 'Ames Ancestor', complete genomehypothetical protein5e-0753.1
NC_012581:755982:764043764043764399357Bacillus anthracis str. CDC 684 chromosome, complete genomehypothetical protein5e-0753.1
NC_012659:3464500:347419034741903474546357Bacillus anthracis str. A0248, complete genomehypothetical protein5e-0753.1
NC_018704:176088:211421211421211801381Amphibacillus xylanus NBRC 15112, complete genomehypothetical protein7e-0649.3
NC_012659:467893:469914469914470270357Bacillus anthracis str. A0248, complete genomehypothetical protein9e-0648.9
NC_005945:467427:470057470057470413357Bacillus anthracis str. Sterne, complete genomehypothetical protein9e-0648.9
NC_003997:467993:470014470014470370357Bacillus anthracis str. Ames, complete genomehypothetical protein9e-0648.9
NC_007530:467993:470014470014470370357Bacillus anthracis str. 'Ames Ancestor', complete genomehypothetical protein9e-0648.9