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Query: NC_010674:2328307:2336106 Clostridium botulinum B str. Eklund 17B, complete genome

Start: 2336106, End: 2336783, Length: 678

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum B str. Eklund 17B is a nonproteolytic botulism neurotoxin B strain. This strain was isolated from marine sediments taken off the coast of Washington, USA and was not associated with botulism. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010723:2269372:227265022726502273324675Clostridium botulinum E3 str. Alaska E43, complete genomeputative phage tail component1e-110398
NC_020291:795500:824893824893825561669Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomephage putative tail component2e-38159
NC_010520:2101515:211484421148442115521678Clostridium botulinum A3 str. Loch Maree, complete genomeputative phage tail protein3e-27122
NC_015425:1295261:132121613212161321896681Clostridium botulinum BKT015925 chromosome, complete genomephage-like protein1e-1583.2
NC_020291:1122282:113714911371491137850702Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomephage-rlike protein3e-1479
NC_010674:950276:965214965214965930717Clostridium botulinum B str. Eklund 17B, complete genomeprophage pi2 protein 438e-1477.4
NC_008593:1362218:137177813717781372461684Clostridium novyi NT, complete genomeconserved phage-related protein1e-1273.2
NC_008261:1787345:179485417948541795564711Clostridium perfringens ATCC 13124, complete genomeputative phage tail component8e-1063.9
NC_012471:781063:813226813226813933708Streptococcus equi subsp. equi 4047, complete genomephage protein1e-0963.2
NC_008021:531730:560741560741561448708Streptococcus pyogenes MGAS9429, complete genomephage protein6e-0961.2
NC_008022:556457:562018562018562725708Streptococcus pyogenes MGAS10270, complete genomephage protein6e-0961.2
NC_008024:572916:579195579195579902708Streptococcus pyogenes MGAS10750, complete genomephage protein6e-0961.2
NC_009332:1269000:127924312792431279950708Streptococcus pyogenes str. Manfredo chromosome, complete genomehypothetical protein6e-0961.2
NC_014218:1663486:167891516789151679607693Arcanobacterium haemolyticum DSM 20595 chromosome, complete genomehypothetical protein1e-0757
NC_014393:4775452:479400947940094794785777Clostridium cellulovorans 743B chromosome, complete genomephage tail component2e-0756.2
NC_006086:987991:9996179996171000324708Streptococcus pyogenes MGAS10394, complete genomeunknown phage protein2e-0755.8
NC_008555:1204000:123664712366471237387741Listeria welshimeri serovar 6b str. SLCC5334, complete genomeconserved phage-related protein1e-0653.5
NC_016627:4270949:430005943000594300832774Clostridium clariflavum DSM 19732 chromosome, complete genomephage putative tail component1e-0653.1
NC_014410:800500:825063825063825836774Thermoanaerobacterium thermosaccharolyticum DSM 571 chromosome,phage tail component2e-0652.4