Pre_GI: BLASTP Hits

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Query: NC_010674:222016:224898 Clostridium botulinum B str. Eklund 17B, complete genome

Start: 224898, End: 225572, Length: 675

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum B str. Eklund 17B is a nonproteolytic botulism neurotoxin B strain. This strain was isolated from marine sediments taken off the coast of Washington, USA and was not associated with botulism. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010723:223935:226817226817227491675Clostridium botulinum E3 str. Alaska E43, complete genome2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase5e-124443
NC_009617:163466:167510167510168190681Clostridium beijerinckii NCIMB 8052 chromosome, complete genome2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase1e-80299
NC_020291:166500:169121169121169798678Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genome2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase IspD3e-76284
NC_008262:2598920:264405026440502644727678Clostridium perfringens SM101, complete genome2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase8e-74276
NC_014393:4482896:452540545254054526094690Clostridium cellulovorans 743B chromosome, complete genome2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase8e-65246
NC_015425:198315:216570216570217256687Clostridium botulinum BKT015925 chromosome, complete genome2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase6e-63240
NC_008593:196257:211905211905212600696Clostridium novyi NT, complete genome2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase3e-62238
NC_015275:3594890:362638636263863627084699Clostridium lentocellum DSM 5427 chromosome, complete genome2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase3e-56218
NC_019970:336472:354725354725355411687Thermoanaerobacterium thermosaccharolyticum M0795, complete genome2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase5e-54210
NC_014378:131810:153312153312154004693Acetohalobium arabaticum DSM 5501 chromosome, complete genome2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase2e-48192
NC_009633:4563877:460549246054924606217726Alkaliphilus metalliredigens QYMF chromosome, complete genome2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase1e-47189
NC_014376:693820:701985701985702701717Clostridium saccharolyticum WM1 chromosome, complete genome2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase6e-47187
NC_014387:719245:726120726120726827708Butyrivibrio proteoclasticus B316 chromosome 1, complete genome2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase IspD17e-46183
NC_010001:434803:444624444624445325702Clostridium phytofermentans ISDg, complete genome2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase3e-45181
NC_012781:751757:761746761746762465720Eubacterium rectale ATCC 33656, complete genome4-diphosphocytidyl-2-methylerithritol synthase (sugar nucleotide phosphorylase family)9e-44176
NC_012778:403962:410990410990411673684Eubacterium eligens ATCC 27750, complete genome2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase1e-43176
NC_017294:1457262:149044314904431491126684Candidatus Arthromitus sp. SFB-mouse-Yit, complete genome2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase9e-43173
NC_015913:1491393:152405315240531524736684Candidatus Arthromitus sp. SFB-mouse-Japan, complete genome2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase9e-43173
NC_011899:86800:111039111039111728690Halothermothrix orenii H 168, complete genome2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase3e-42171
NC_011297:1296968:130152913015291302224696Dictyoglomus thermophilum H-6-12, complete genome2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase1e-39162
NC_002570:126500:141464141464142150687Bacillus halodurans C-125, complete genome2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase9e-39160
NC_013890:53538:549195491955602684Dehalococcoides sp. GT chromosome, complete genome2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase8e-36150
NC_003454:63500:903149031491009696Fusobacterium nucleatum subsp. nucleatum ATCC 25586, complete2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase5e-35147
NC_009455:53000:547995479955482684Dehalococcoides sp. BAV1 chromosome, complete genome2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase2e-34145
NC_007356:51080:553805538056063684Dehalococcoides sp. CBDB1, complete genome2-C-methyl-D-erythritol 4-phosphatecytidylyltransferase2e-34145
NC_017208:64500:104924104924105562639Bacillus thuringiensis serovar chinensis CT-43 chromosome, complete2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase4e-34144
NC_019903:421000:434832434832435518687Desulfitobacterium dichloroeliminans LMG P-21439 chromosome,2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase2e-33142
NC_010382:4479464:448955244895524490247696Lysinibacillus sphaericus C3-41, complete genome2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase4e-33141
NC_006138:273237:2770292770292783301302Desulfotalea psychrophila LSv54, complete genomesimilar to IspD/IspF bifunctional enzyme (Rhodobacter capsulatus)8e-33140
NC_012673:1600242:160024216002421600922681Exiguobacterium sp. AT1b, complete genome2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase1e-32140
NC_013037:3994083:399408339940833994763681Dyadobacter fermentans DSM 18053, complete genome2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase8e-31133
NC_016077:998741:103420010342001034922723Acidaminococcus intestini RyC-MR95 chromosome, complete genome2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase3e-30131
NC_012438:50845:553225532255972651Sulfurihydrogenibium azorense Az-Fu1 chromosome, complete genome2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase3e-30131
NC_009615:4642500:466368346636834664414732Parabacteroides distasonis ATCC 8503 chromosome, complete genomeCDP-ribitol pyrophosphorylase3e-30131
NC_013165:1665014:167870216787021679427726Slackia heliotrinireducens DSM 20476, complete genome4-diphosphocytidyl-2-methyl-D-erythritol synthase3e-30131
NC_002950:1511955:151916215191621519830669Porphyromonas gingivalis W83, complete genome2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase5e-30130
NC_016047:3632489:365041336504133651126714Bacillus subtilis subsp. spizizenii TU-B-10 chromosome, completeribitol-5-phosphate cytidylyltransferase9e-29127
NC_014479:3452484:347251334725133473226714Bacillus subtilis subsp. spizizenii str. W23 chromosome, completeputative D-ribitol-5-phosphate cytidylyltransferase7e-29127
NC_013410:1203937:120942212094221210144723Fibrobacter succinogenes subsp. succinogenes S85 chromosome,4-diphosphocytidyl-2C-methyl-D-erythritol synthase6e-29127
NC_019896:536500:539338539338540051714Bacillus subtilis subsp. subtilis str. BSP1 chromosome, completeRibitol-5-phosphate cytidylyltransferase6e-29127
NC_004461:277291:321117321117321833717Staphylococcus epidermidis ATCC 12228, complete genome2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase5e-29127
NC_020244:3490460:350827735082773508990714Bacillus subtilis XF-1, complete genomeputative ribitol-5-phosphate cytidylyltransferase2e-28125
NC_021175:1973880:198258419825841983306723Streptococcus oligofermentans AS 1.3089, complete genome2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase3e-28125
NC_015064:1268223:126981812698181270552735Acidobacterium sp. MP5ACTX9 chromosome, complete genome2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase5e-28124
NC_010468:1029471:105139410513941052104711Escherichia coli ATCC 8739, complete genome2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase9e-28123
NC_014833:3362500:336555233655523366304753Ruminococcus albus 7 chromosome, complete genome4-diphosphocytidyl-2C-methyl-D-erythritol synthase3e-27122
NC_012751:1538500:155637815563781557103726Candidatus Hamiltonella defensa 5AT (Acyrthosiphon pisum), complete4-diphosphocytidyl-2C-methyl-D-erythritol synthase2e-27122
NC_016751:1299738:131328413132841313979696Marinitoga piezophila KA3 chromosome, complete genome2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase1e-27122
NC_015500:1923514:193508119350811935794714Treponema brennaborense DSM 12168 chromosome, complete genome2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase3e-26118
NC_013946:415028:439569439569440201633Meiothermus ruber DSM 1279 chromosome, complete genome2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase1e-25116
NC_017068:2436960:246019724601972460907711Selenomonas ruminantium subsp. lactilytica TAM6421, completeputative 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase1e-25116
NC_002940:1065246:108703710870371087717681Haemophilus ducreyi 35000HP, complete genome2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase1e-25116
NC_007519:1782067:1783902178390217851011200Desulfovibrio alaskensis G20 chromosome, complete genome2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase2e-25115
NC_012967:3012317:302468630246863025408723Escherichia coli B str. REL606 chromosome, complete genomePyrophosphorylase2e-24112
NC_009482:619467:618779618779619480702Synechococcus sp. RCC307 chromosome, complete genome2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase4e-24111
NC_016633:1353458:135732013573201358132813Sphaerochaeta pleomorpha str. Grapes chromosome, complete genome4-diphosphocytidyl-2-methyl-D-erythritol synthase7e-24110
NC_009615:2184300:2193354219335421947241371Parabacteroides distasonis ATCC 8503 chromosome, complete genomepyrophosphorylase1e-23109
NC_007984:221030:224342224342225067726Baumannia cicadellinicola str. Hc (Homalodisca coagulata), complete2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase2e-23109
NC_010483:1441614:144814614481461448814669Thermotoga sp. RQ2, complete genome2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase2e-23108
NC_009615:4425500:443824844382484438958711Parabacteroides distasonis ATCC 8503 chromosome, complete genome2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase2e-23108
NC_016842:546661:5491445491445503911248Treponema pallidum subsp. pertenue str. SamoaD chromosome, completebifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase8e-23107
NC_016843:547149:5496325496325508791248Treponema pallidum subsp. pertenue str. Gauthier chromosome,bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase8e-23107
NC_016848:547115:5495985495985508451248Treponema pallidum subsp. pertenue str. CDC2 chromosome, completebifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase8e-23107
NC_010741:546573:5490565490565503031248Treponema pallidum subsp. pallidum SS14, complete genomehypothetical protein8e-23107
NC_016844:547069:5495525495525507991248Treponema pallidum subsp. pallidum DAL-1 chromosome, completebifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase8e-23107
NC_017268:546376:5488595488595501061248Treponema pallidum subsp. pallidum str. Chicago chromosome,bifunctional enzyme IspD/ispF8e-23107
NC_021508:546592:5490755490755503221248Treponema pallidum subsp. pallidum SS14, complete genomebifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase8e-23107
NC_016445:2938887:297110229711022971800699Vibrio cholerae O1 str. 2010EL-1786 chromosome 1, complete2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase7e-23107
NC_015714:542679:5451615451615464081248Treponema paraluiscuniculi Cuniculi A chromosome, complete genomebifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase2e-22106
NC_013740:842841:861129861129861851723Acidaminococcus fermentans DSM 20731, complete genome4-diphosphocytidyl-2C-methyl-D-erythritol synthase3e-22105
NC_016632:285408:297985297985298701717Serratia symbiotica str. 'Cinara cedri' chromosome, complete2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase3e-22105
NC_000919:545141:5476725476725488711200Treponema pallidum subsp. pallidum str. Nichols, complete genomehypothetical protein3e-21102
NC_010995:2547164:255803825580382558808771Cellvibrio japonicus Ueda107, complete genome2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase2e-21102
NC_015738:838715:859734859734860576843Eggerthella sp. YY7918, complete genomehypothetical protein3e-21101
NC_009615:1553556:157020415702041570893690Parabacteroides distasonis ATCC 8503 chromosome, complete genomenucleotidyltransferase4e-21101
NC_004344:589375:614839614839615528690Wigglesworthia glossinidia endosymbiont of Glossina brevipalpis,hypothetical protein1e-20100
NC_014562:2563466:260795326079532608669717Pantoea vagans C9-1 chromosome, complete genome2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase1e-2099.8
NC_014962:4538122:454252945425294543311783Isosphaera pallida ATCC 43644 chromosome, complete genome2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase2e-2099.4
NC_016148:951446:9724609724609736141155Thermovirga lienii DSM 17291 chromosome, complete genome2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase2e-2099
NC_014033:1691822:170533917053391706103765Prevotella ruminicola 23 chromosome, complete genome5e-2097.8
NC_005085:1269787:132290313229031323580678Chromobacterium violaceum ATCC 12472, complete genome4-diphosphocytidyl-2C-methyl-D-erythritol synthase2e-1995.5
NC_009614:3748950:374895037489503749672723Bacteroides vulgatus ATCC 8482 chromosome, complete genome2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase3e-1995.1
NC_013172:2934572:294340329434032944089687Brachybacterium faecium DSM 4810, complete genome4-diphosphocytidyl-2-methyl-D-erythritol synthase6e-1994.4
NC_006831:157895:159569159569160297729Ehrlichia ruminantium str. Gardel, complete genome2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase9e-1993.6
NC_006832:160222:161900161900162628729Ehrlichia ruminantium str. Welgevonden, complete genome2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase1e-1892.8
NC_013165:1665014:167113616711361671822687Slackia heliotrinireducens DSM 20476, complete genome4-diphosphocytidyl-2-methyl-D-erythritol synthase2e-1789
NC_009953:1936463:1936463193646319380161554Salinispora arenicola CNS-205 chromosome, complete genome4-diphosphocytidyl-2C-methyl-D-erythritol synthase6e-1787.8
NC_013165:1407000:142473714247371425702966Slackia heliotrinireducens DSM 20476, complete genome4-diphosphocytidyl-2-methyl-D-erythritol synthase1e-1686.7
NC_011295:779569:7849447849447860321089Coprothermobacter proteolyticus DSM 5265, complete genomebifunctional enzyme IspD/ispF4e-1685.1
NC_016043:471719:492293492293493006714Taylorella asinigenitalis MCE3 chromosome, complete genome2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase2e-1582.4
NC_013174:2013000:2013258201325820147091452Jonesia denitrificans DSM 20603, complete genome4-diphosphocytidyl-2C-methyl-D-erythritol synthase4e-1581.6
NC_012778:263241:291669291669292343675Eubacterium eligens ATCC 27750, complete genome2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase5e-1581.3
NC_008601:631504:654135654135654824690Francisella tularensis subsp. novicida U112, complete genome2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase7e-1580.9
NC_006570:707280:729286729286729975690Francisella tularensis subsp. tularensis Schu 4, complete genome2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase7e-1580.5
NC_008245:707984:729238729238729927690Francisella tularensis subsp. tularensis FSC 198, complete genome2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase7e-1580.5
NC_014109:27500:339703397034698729Candidatus Riesia pediculicola USDA chromosome, complete genome2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase7e-1477.4
NC_010336:213148:231933231933232625693Francisella philomiragia subsp. philomiragia ATCC 25017, complete2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase2e-1376.3
NC_013165:1407000:142587714258771426605729Slackia heliotrinireducens DSM 20476, complete genome4-diphosphocytidyl-2-methyl-D-erythritol synthase4e-1375.1
NC_006624:1494424:150749115074911508180690Thermococcus kodakarensis KOD1, complete genomecytidylyltransferase4e-1374.7
NC_016933:783938:805240805240805881642Francisella tularensis TIGB03 chromosome, complete genome2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase1e-1273.2
NC_016937:707279:729333729333729974642Francisella tularensis subsp. tularensis TI0902 chromosome,2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase1e-1273.2
NC_015696:1749863:175113017511301751822693Francisella sp. TX077308 chromosome, complete genome2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase4e-1271.6
NC_016642:990058:998459998459998854396Pseudovibrio sp. FO-BEG1 chromosome, complete genome2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase2e-0962.4
NC_005090:1812833:1835616183561618367551140Wolinella succinogenes DSM 1740, complete genomebifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein2e-0755.8
NC_009515:967600:970069970069970686618Methanobrevibacter smithii ATCC 35061, complete genomeGTP:adenosylcobinamide-phosphate guanylyltransferase9e-0650.4