Pre_GI: BLASTP Hits

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Query: NC_010674:2185704:2208526 Clostridium botulinum B str. Eklund 17B, complete genome

Start: 2208526, End: 2208813, Length: 288

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum B str. Eklund 17B is a nonproteolytic botulism neurotoxin B strain. This strain was isolated from marine sediments taken off the coast of Washington, USA and was not associated with botulism. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010723:2082750:210369021036902103977288Clostridium botulinum E3 str. Alaska E43, complete genomeDNA polymerase, beta domain protein region5e-36149
NC_014915:2427000:243127524312752431571297Geobacillus sp. Y412MC52 chromosome, complete genomeDNA polymerase beta domain protein region protein8e-1889
NC_013411:284461:307917307917308213297Geobacillus sp. Y412MC61, complete genomeDNA polymerase beta domain protein region8e-1889
NC_014915:2427000:244982624498262450125300Geobacillus sp. Y412MC52 chromosome, complete genomeDNA polymerase beta domain protein region protein8e-1785.9
NC_013411:284461:289363289363289662300Geobacillus sp. Y412MC61, complete genomeDNA polymerase beta domain protein region8e-1785.9
NC_012691:2225000:224555522455552245893339Tolumonas auensis DSM 9187, complete genomeDNA polymerase beta domain protein region4e-0753.5