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Query: NC_010674:2185704:2207222 Clostridium botulinum B str. Eklund 17B, complete genome

Start: 2207222, End: 2208364, Length: 1143

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum B str. Eklund 17B is a nonproteolytic botulism neurotoxin B strain. This strain was isolated from marine sediments taken off the coast of Washington, USA and was not associated with botulism. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010723:2082750:2102385210238521035271143Clostridium botulinum E3 str. Alaska E43, complete genomedivergent AAA domain family0731
NC_016627:4535000:4538012453801245391511140Clostridium clariflavum DSM 19732 chromosome, complete genomeputative transcriptional regulator with HTH domain7e-76284
NC_016051:241438:2647172647172660571341Thermococcus sp. AM4 chromosome, complete genomeATP-dependent DNA helicase6e-1582
NC_015676:1009298:1024766102476610262351470Methanosalsum zhilinae DSM 4017 chromosome, complete genomeputative transcriptional regulator2e-1480.1
NC_007514:1475323:1488373148837314895811209Chlorobium chlorochromatii CaD3, complete genomeputative transcriptional regulator3e-1479.7
NC_009655:866281:8716948716948729051212Actinobacillus succinogenes 130Z chromosome, complete genomeputative transcriptional regulator1e-1377.8
NC_010995:4338860:4354146435414643556061461Cellvibrio japonicus Ueda107, complete genomeATP-dependent DNA helicase3e-1376.6
NC_013410:1152188:1167781116778111693191539Fibrobacter succinogenes subsp. succinogenes S85 chromosome,transcriptional regulator4e-1272.8
NC_015703:4933430:4968265496826549697251461Runella slithyformis DSM 19594 chromosome, complete genomeputative transcriptional regulator5e-1272.4
NC_015510:6373937:6381529638152963826921164Haliscomenobacter hydrossis DSM 1100 chromosome, complete genomeputative transcriptional regulator2e-1170.1
NC_015577:1794560:1822146182214618233241179Treponema azotonutricium ZAS-9 chromosome, complete genomeATP-dependent DNA helicase9e-1168.2
NC_019902:1863162:1870066187006618713071242Thioalkalivibrio nitratireducens DSM 14787, complete genomeATP-dependent DNA helicase-like protein3e-1066.6
NC_015873:450593:4561264561264575801455Megasphaera elsdenii DSM 20460, complete genomepredicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen8e-1065.1
NC_009767:2051203:2069909206990920710691161Roseiflexus castenholzii DSM 13941, complete genomeputative transcriptional regulator8e-1065.1
NC_010816:2326453:2340005234000523415521548Bifidobacterium longum DJO10A, complete genomePutative transcriptional regulator6e-0962
NC_017221:535000:5475075475075490841578Bifidobacterium longum subsp. longum KACC 91563 chromosome,hypothetical protein7e-0962
NC_015052:1771976:1780316178031617818631548Bifidobacterium longum subsp. infantis 157F, complete genometranscriptional regulator7e-0962
NC_007514:904565:9303709303709315271158Chlorobium chlorochromatii CaD3, complete genomeputative transcriptional regulator1e-0861.2
NC_015577:2081196:2088094208809420894521359Treponema azotonutricium ZAS-9 chromosome, complete genomeputative transcriptional regulator4e-0756.2
NC_016943:2054688:2065953206595320671281176Blastococcus saxobsidens DD2, complete genomeputative transcriptional regulator5e-0755.8
NC_019977:302454:3112663112663126121347Methanomethylovorans hollandica DSM 15978, complete genomeputative transcriptional regulator with HTH domain6e-0755.5
NC_007575:973559:9873209873209886601341Sulfurimonas denitrificans DSM 1251, complete genomeputative transcriptional regulator1e-0654.7
NC_013192:232778:2366962366962381591464Leptotrichia buccalis DSM 1135, complete genomeputative transcriptional regulator2e-0653.5