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Query: NC_010674:2185704:2199758 Clostridium botulinum B str. Eklund 17B, complete genome

Start: 2199758, End: 2201422, Length: 1665

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum B str. Eklund 17B is a nonproteolytic botulism neurotoxin B strain. This strain was isolated from marine sediments taken off the coast of Washington, USA and was not associated with botulism. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010723:2082750:2094622209462220962861665Clostridium botulinum E3 str. Alaska E43, complete genomecoenzyme B12-dependent glycerol dehydratase, large subunit01083
NC_009648:3803622:3847033384703338487001668Klebsiella pneumoniae subsp. pneumoniae MGH 78578, complete genomeglycerol dehydratase0965
NC_008262:1139500:1145256114525611469201665Clostridium perfringens SM101, complete genomeglycerol dehydratase, alpha subunit0958
NC_003366:1122654:1127780112778011294441665Clostridium perfringens str. 13, complete genomecoenzyme B12-dependent glycerol dehydrogenase large subunit0958
NC_008261:1332864:1338644133864413403081665Clostridium perfringens ATCC 13124, complete genomecoenzyme B12-dependent glycerol dehydratase, large subunit0958
NC_014632:1404000:1414557141455714162211665Ilyobacter polytropus DSM 2926 chromosome, complete genomeglycerol dehydratase, cobalamin-dependent subunit alpha0912
NC_013517:1055854:1115745111574511174061662Sebaldella termitidis ATCC 33386, complete genomeGlycerol dehydratase0872
NC_017243:1813158:1830914183091418325751662Brachyspira intermedia PWS/A chromosome, complete genomeglycerol dehydratase0869
NC_019970:2080419:2091622209162220932891668Thermoanaerobacterium thermosaccharolyticum M0795, complete genomepropanediol dehydratase, large subunit0858
NC_014538:985339:9909889909889926521665Thermoanaerobacter sp. X513 chromosome, complete genomeglycerol dehydratase0852
NC_010320:1949852:1961692196169219633561665Thermoanaerobacter sp. X514 chromosome, complete genomeglycerol dehydratase0852
NC_013766:1202713:1206732120673212083961665Listeria monocytogenes 08-5578 chromosome, complete genomehypothetical protein0841
NC_012488:1159463:1164779116477911664431665Listeria monocytogenes Clip81459, complete genomepropanediol dehydratase, alpha subunit0837
NC_014633:442755:4521894521894538531665Ilyobacter polytropus DSM 2926 plasmid pILYOP01, complete sequenceglycerol dehydratase0821
NC_011601:2139188:2185408218540821870091602Escherichia coli O127:H6 str. E2348/69 chromosome, complete genomepropanediol dehydratase, large subunit, AdoCbl-dependent0791
NC_014654:1113116:1118629111862911202991671Halanaerobium sp. 'sapolanicus' chromosome, complete genomeGlycerol dehydratase0786
NC_008497:1575884:1577164157716415788401677Lactobacillus brevis ATCC 367, complete genomePropanediol dehydratase, large subunit0753
NC_011837:830436:8443988443988460621665Clostridium kluyveri NBRC 12016, complete genomehypothetical protein0723
NC_009706:830461:8444238444238460871665Clostridium kluyveri DSM 555 chromosome, complete genomeprotein DhaA0723