Pre_GI: BLASTP Hits

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Query: NC_010674:2185704:2199164 Clostridium botulinum B str. Eklund 17B, complete genome

Start: 2199164, End: 2199739, Length: 576

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum B str. Eklund 17B is a nonproteolytic botulism neurotoxin B strain. This strain was isolated from marine sediments taken off the coast of Washington, USA and was not associated with botulism. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010723:2082750:209402920940292094604576Clostridium botulinum E3 str. Alaska E43, complete genomepropanediol utilization: dehydratase, medium subunit1e-96351
NC_003366:1122654:112945211294521130024573Clostridium perfringens str. 13, complete genomecoenzyme B12-dependent glycerol dehydrogenase medium subunit1e-72272
NC_008262:1139500:114693411469341147500567Clostridium perfringens SM101, complete genomeglycerol dehydratase, beta subunit2e-72271
NC_008261:1332864:134032213403221340888567Clostridium perfringens ATCC 13124, complete genomecoenzyme B12-dependent glycerol dehydratase, medium subunit3e-72271
NC_014632:1404000:141397914139791414542564Ilyobacter polytropus DSM 2926 chromosome, complete genomeglycerol dehydratase, cobalamin-dependent subunit beta6e-66249
NC_014633:442755:453864453864454517654Ilyobacter polytropus DSM 2926 plasmid pILYOP01, complete sequencedehydratase medium subunit3e-64244
NC_019970:2080419:209095120909512091607657Thermoanaerobacterium thermosaccharolyticum M0795, complete genomeDehydratase medium subunit4e-61234
NC_017243:1813158:183021718302171830903687Brachyspira intermedia PWS/A chromosome, complete genomedehydratase medium subunit6e-60229
NC_013517:1055854:111742611174261118100675Sebaldella termitidis ATCC 33386, complete genomedehydratase medium subunit1e-59228
NC_012488:1159463:116648111664811167140660Listeria monocytogenes Clip81459, complete genomediol dehydrase (diol dehydratase) gamma subunit7e-59226
NC_013766:1202713:120843412084341209093660Listeria monocytogenes 08-5578 chromosome, complete genomehypothetical protein9e-59226
NC_009648:3803622:384643638464363847020585Klebsiella pneumoniae subsp. pneumoniae MGH 78578, complete genomeglycerol dehydratase8e-58223
NC_010320:1949852:196096919609691961658690Thermoanaerobacter sp. X514 chromosome, complete genomedehydratase, medium subunit8e-56216
NC_014538:985339:992686992686993375690Thermoanaerobacter sp. X513 chromosome, complete genomedehydratase medium subunit8e-56216
NC_008497:1575884:157642415764241577143720Lactobacillus brevis ATCC 367, complete genomeDiol Dehydratase medium subunit5e-50196
NC_014654:1113116:112032411203241120980657Halanaerobium sp. 'sapolanicus' chromosome, complete genomedehydratase medium subunit1e-49196