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Query: NC_010674:2185704:2198720 Clostridium botulinum B str. Eklund 17B, complete genome

Start: 2198720, End: 2199142, Length: 423

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum B str. Eklund 17B is a nonproteolytic botulism neurotoxin B strain. This strain was isolated from marine sediments taken off the coast of Washington, USA and was not associated with botulism. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010723:2082750:209358520935852094007423Clostridium botulinum E3 str. Alaska E43, complete genomecoenzyme B12-dependent glycerol dehydratase, small subunit4e-73272
NC_003366:1122654:113004411300441130469426Clostridium perfringens str. 13, complete genomecoenzyme B12-dependent glycerol dehydrogenase small subunit2e-56217
NC_008261:1332864:134090813409081341333426Clostridium perfringens ATCC 13124, complete genomecoenzyme B12-dependent glycerol dehydratase, small subunit2e-56217
NC_008262:1139500:114752011475201147945426Clostridium perfringens SM101, complete genomeglycerol dehydrase, gamma subunit6e-56215
NC_009648:3803622:384600838460083846433426Klebsiella pneumoniae subsp. pneumoniae MGH 78578, complete genomeglycerol dehydratase2e-47187
NC_013517:1055854:111811411181141118614501Sebaldella termitidis ATCC 33386, complete genomedehydratase small subunit1e-43174
NC_014633:442755:454556454556455038483Ilyobacter polytropus DSM 2926 plasmid pILYOP01, complete sequencedehydratase small subunit6e-43172
NC_012488:1159463:116715711671571167669513Listeria monocytogenes Clip81459, complete genomediol dehydrase (diol dehydratase) gamma subunit (pddC)6e-42169
NC_013766:1202713:120911012091101209622513Listeria monocytogenes 08-5578 chromosome, complete genomehypothetical protein7e-42169
NC_008497:1575884:157588415758841576411528Lactobacillus brevis ATCC 367, complete genomePropanediol dehydratase, small subunit2e-41167
NC_010320:1949852:196045519604551960979525Thermoanaerobacter sp. X514 chromosome, complete genomedehydratase, small subunit1e-40164
NC_014538:985339:993365993365993889525Thermoanaerobacter sp. X513 chromosome, complete genomedehydratase small subunit1e-40164
NC_014632:1404000:141353514135351413966432Ilyobacter polytropus DSM 2926 chromosome, complete genomeglycerol dehydratase, cobalamin-dependent subunit gamma3e-40163
NC_019970:2080419:209043520904352090938504Thermoanaerobacterium thermosaccharolyticum M0795, complete genomepropanediol dehydratase, small subunit6e-39159
NC_009706:830461:846190846190846720531Clostridium kluyveri DSM 555 chromosome, complete genomeprotein DhaC1e-38157
NC_011837:830436:846147846147846695549Clostridium kluyveri NBRC 12016, complete genomehypothetical protein1e-38157
NC_017243:1813158:182969218296921830171480Brachyspira intermedia PWS/A chromosome, complete genomeglycerol dehydrase4e-38156
NC_014654:1113116:112100611210061121524519Halanaerobium sp. 'sapolanicus' chromosome, complete genomedehydratase small subunit2e-33140