Pre_GI: BLASTP Hits

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Query: NC_010674:2185704:2196854 Clostridium botulinum B str. Eklund 17B, complete genome

Start: 2196854, End: 2198692, Length: 1839

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum B str. Eklund 17B is a nonproteolytic botulism neurotoxin B strain. This strain was isolated from marine sediments taken off the coast of Washington, USA and was not associated with botulism. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010723:2082750:2091719209171920935571839Clostridium botulinum E3 str. Alaska E43, complete genomeglycerol dehydratase reactivation factor large subunit01136
NC_008262:1139500:1147962114796211498121851Clostridium perfringens SM101, complete genomeglycerol dehydratase reactivation factor, large subunit0950
NC_008261:1332864:1341350134135013432001851Clostridium perfringens ATCC 13124, complete genomeglycerol dehydratase reactivation factor, large subunit0948
NC_003366:1122654:1130486113048611323361851Clostridium perfringens str. 13, complete genomeprobable glycerol dehydratase large subunit0946
NC_014633:442755:4550624550624568761815Ilyobacter polytropus DSM 2926 plasmid pILYOP01, complete sequenceglycerol dehydratase reactivation factor, large subunit0748
NC_009648:3803622:3844172384417238459951824Klebsiella pneumoniae subsp. pneumoniae MGH 78578, complete genomeglycerol dehyrdratase activator0740
NC_013517:1055854:1118724111872411205531830Sebaldella termitidis ATCC 33386, complete genomeDiol/glycerol dehydratase reactivating factor large subunit0736
NC_014632:1404000:1411693141169314135161824Ilyobacter polytropus DSM 2926 chromosome, complete genomeglycerol dehydratase reactivation factor, large subunit0728
NC_017243:1813158:1827615182761518294861872Brachyspira intermedia PWS/A chromosome, complete genomediol/glycerol dehydratase reactivating factor large subunit0726
NC_019970:2080419:2088596208859620904191824Thermoanaerobacterium thermosaccharolyticum M0795, complete genomeexopolyphosphatase0724
NC_013766:1202713:1209667120966712114871821Listeria monocytogenes 08-5578 chromosome, complete genomehypothetical protein0720
NC_012488:1159463:1167715116771511695351821Listeria monocytogenes Clip81459, complete genomediol dehydratase-reactivating factor large subunit0720
NC_010320:1949852:1958620195862019604341815Thermoanaerobacter sp. X514 chromosome, complete genomehypothetical protein0687
NC_014538:985339:9939109939109957241815Thermoanaerobacter sp. X513 chromosome, complete genomeDiol/glycerol dehydratase reactivating factor large subunit0687
NC_014654:1113116:1121549112154911233901842Halanaerobium sp. 'sapolanicus' chromosome, complete genomeDiol/glycerol dehydratase reactivating factor large subunit0684
NC_016860:397138:411643411643412020378Salmonella enterica subsp. enterica serovar Typhimurium strhypothetical protein9e-48192
NC_011205:371001:373577373577373945369Salmonella enterica subsp. enterica serovar Dublin str. CT_020218532e-38160
NC_011083:403022:417314417314417682369Salmonella enterica subsp. enterica serovar Heidelberg str. SL476,3e-38160
NC_011294:346915:349491349491349856366Salmonella enterica subsp. enterica serovar Enteritidis str3e-38160
NC_016860:397138:411387411387411659273Salmonella enterica subsp. enterica serovar Typhimurium strhypothetical protein2e-1894.7