Pre_GI: BLASTP Hits

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Query: NC_010674:2185704:2195961 Clostridium botulinum B str. Eklund 17B, complete genome

Start: 2195961, End: 2196473, Length: 513

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum B str. Eklund 17B is a nonproteolytic botulism neurotoxin B strain. This strain was isolated from marine sediments taken off the coast of Washington, USA and was not associated with botulism. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010723:2082750:209082620908262091338513Clostridium botulinum E3 str. Alaska E43, complete genomeATP:cob(I)alamin adenosyltransferase1e-75281
NC_003366:1122654:113269811326981133210513Clostridium perfringens str. 13, complete genomehypothetical protein2e-53207
NC_008261:1332864:134356213435621344074513Clostridium perfringens ATCC 13124, complete genomeputative ATP:cob(I)alamin adenosyltransferase5e-53206
NC_008262:1139500:115017411501741150686513Clostridium perfringens SM101, complete genomeATP:cob(I)alamin adenosyltransferase, putative6e-53206
NC_014633:442755:4598114598114608661056Ilyobacter polytropus DSM 2926 plasmid pILYOP01, complete sequenceATP/cobalamin adenosyltransferase1e-31135
NC_015732:191554:211934211934212458525Spirochaeta caldaria DSM 7334 chromosome, complete genomeATP/cobalamin adenosyltransferase2e-27121
NC_016510:2856000:286604928660492866618570Flavobacterium columnare ATCC 49512 chromosome, complete genomehypothetical protein4e-27120
NC_013730:1342500:134251813425181343096579Spirosoma linguale DSM 74, complete genomeATP/cobalamin adenosyltransferase2e-26118
NC_010729:1344903:136228613622861362849564Porphyromonas gingivalis ATCC 33277, complete genomeprobable ATP:corrinoid adenosyltransferase4e-26117
NC_015496:2279829:229059122905912291166576Krokinobacter diaphorus 4H-3-7-5 chromosome, complete genomeATP/cobalamin adenosyltransferase6e-26116
NC_010320:1949852:1953972195397219549731002Thermoanaerobacter sp. X514 chromosome, complete genomeATP--cobalamin adenosyltransferase3e-25114
NC_014538:985339:99937199937110003721002Thermoanaerobacter sp. X513 chromosome, complete genomeATP/cobalamin adenosyltransferase3e-25114
NC_013766:1202713:121483912148391215834996Listeria monocytogenes 08-5578 chromosome, complete genomeATP:cob(I)alamin adenosyltransferase protein PduO6e-25113
NC_012488:1159463:117288711728871173882996Listeria monocytogenes Clip81459, complete genomePduO protein2e-24111
NC_020156:49666:560775607756649573Nonlabens dokdonensis DSW-6, complete genomecobalamin adenosyltransferase6e-24109
NC_004193:950000:954682954682955245564Oceanobacillus iheyensis HTE831, complete genomehypothetical protein1e-22105
NC_013525:556036:567707567707568231525Thermobaculum terrenum ATCC BAA-798 chromosome 1, complete genomeATP/cobalamin adenosyltransferase2e-22105
NC_018704:645843:654533654533655093561Amphibacillus xylanus NBRC 15112, complete genomecob(I)alamin adenosyltransferase2e-22105
NC_020054:6259733:627729462772946277860567Fibrella aestuarina BUZ 2 drat genomeATP/cobalamin adenosyltransferase8e-22102
NC_014376:1586649:159213015921301592708579Clostridium saccharolyticum WM1 chromosome, complete genomeATP/cobalamin adenosyltransferase1e-21102
NC_000961:597385:598068598068598586519Pyrococcus horikoshii OT3, complete genomehypothetical protein4e-21100
NC_009922:868262:870253870253870834582Alkaliphilus oremlandii OhILAs, complete genomeATP--cobalamin adenosyltransferase3e-21100
NC_009937:53082:722277222772811585Azorhizobium caulinodans ORS 571, complete genomecobalamin adenosyltransferase2e-2098.2
NC_019970:2080419:208445520844552085420966Thermoanaerobacterium thermosaccharolyticum M0795, complete genomeATP:cob(I)alamin adenosyltransferase2e-2098.2
NC_007005:4857768:487664148766414877219579Pseudomonas syringae pv. syringae B728a, complete genomeProtein of unknown function DUF803e-2097.8
NC_012588:1419318:143704814370481437572525Sulfolobus islandicus M.14.25 chromosome, complete genomeATP--cobalamin adenosyltransferase1e-1995.9
NC_012632:1543735:156146515614651561989525Sulfolobus islandicus M.16.27 chromosome, complete genomeATP--cobalamin adenosyltransferase1e-1995.9
NC_012622:1395601:141439314143931414917525Sulfolobus islandicus Y.G.57.14 chromosome, complete genomeATP/cobalamin adenosyltransferase1e-1995.9
NC_012623:1141951:114317511431751143699525Sulfolobus islandicus Y.N.15.51 chromosome, complete genomeATP/cobalamin adenosyltransferase1e-1995.9
NC_004578:4940000:496097949609794961557579Pseudomonas syringae pv. tomato str. DC3000, complete genomeATP:cob(I)alamin adenosyltransferase, putative1e-1995.9
NC_011026:2624775:264498726449872645562576Chloroherpeton thalassium ATCC 35110, complete genomeATP/cobalamin adenosyltransferase1e-1995.5
NC_010729:1385217:140788214078821408448567Porphyromonas gingivalis ATCC 33277, complete genomeprobable cobalamin adenosyltransferase2e-1994.7
NC_002754:513790:515500515500516024525Sulfolobus solfataricus P2, complete genomehypothetical protein3e-1994.7
NC_013922:331847:382674382674383207534Natrialba magadii ATCC 43099 chromosome, complete genomeATP/cobalamin adenosyltransferase6e-1890.1
NC_006347:2861498:287576528757652876340576Bacteroides fragilis YCH46, complete genomeputative ATP:cob(I)alamin adenosyltransferase2e-1788.6
NC_003228:2929006:294937829493782949953576Bacteroides fragilis NCTC 9343, complete genomeputative cobalamin adenosyltransferase2e-1788.6
NC_016776:2913966:293435829343582934933576Bacteroides fragilis 638R, complete genomeputative cobalamin adenosyltransferase2e-1788.6
NC_014654:1113116:112692611269261127492567Halanaerobium sp. 'sapolanicus' chromosome, complete genomeATP/cobalamin adenosyltransferase3e-1787.8
NC_010524:1005355:100569410056941006269576Leptothrix cholodnii SP-6, complete genomeATP--cobalamin adenosyltransferase6e-1786.7
NC_008343:88184:104341104341104913573Granulibacter bethesdensis CGDNIH1, complete genomecobalamin adenosyltransferase family protein9e-1786.3
NC_010382:1020516:102205910220591022550492Lysinibacillus sphaericus C3-41, complete genomehypothetical protein1e-1685.5
NC_003106:1457802:145903314590331459566534Sulfolobus tokodaii str. 7, complete genomehypothetical protein2e-1581.6
NC_018750:5399316:541655454165545417126573Streptomyces venezuelae ATCC 10712, complete genomeCob(I)alamin adenosyltransferase PduO4e-1477.4
NC_002689:78297:102084102084102626543Thermoplasma volcanium GSS1, complete genomehypothetical protein3e-1374.3
NC_019673:8114376:812299581229958123567573Saccharothrix espanaensis DSM 44229 complete genomehypothetical protein4e-1374.3
NC_015435:570980:577330577330577854525Metallosphaera cuprina Ar-4 chromosome, complete genomeATP:cob(I)alamin adenosyltransferase5e-1373.9
NC_013093:7174636:718557571855757186147573Actinosynnema mirum DSM 43827, complete genomeATP/cobalamin adenosyltransferase1e-1272.4
NC_016109:5543112:555837355583735558945573Kitasatospora setae KM-6054, complete genomeputative cobalamin adenosyltransferase2e-1168.6
NC_015320:1260344:127849812784981278980483Archaeoglobus veneficus SNP6 chromosome, complete genomecobalamin adenosyltransferase4e-1063.9
NC_012623:960327:962799962799963317519Sulfolobus islandicus Y.N.15.51 chromosome, complete genomeATP/cobalamin adenosyltransferase5e-0857.4
NC_012588:1585808:160529816052981605816519Sulfolobus islandicus M.14.25 chromosome, complete genomeATP--cobalamin adenosyltransferase1e-0755.8
NC_012622:1646000:166330316633031663821519Sulfolobus islandicus Y.G.57.14 chromosome, complete genomeATP/cobalamin adenosyltransferase1e-0755.8
NC_012726:1611936:163142816314281631946519Sulfolobus islandicus M.16.4 chromosome, complete genomeATP--cobalamin adenosyltransferase1e-0755.8
NC_013769:1705500:172446117244611724979519Sulfolobus islandicus L.D.8.5 chromosome, complete genomeATP--cobalamin adenosyltransferase1e-0755.8
NC_017275:1635959:165550916555091656027519Sulfolobus islandicus HVE10/4 chromosome, complete genomeATP-cobalamin adenosyltransferase1e-0755.8
NC_017276:1491473:151102415110241511542519Sulfolobus islandicus REY15A chromosome, complete genomeATP-cobalamin adenosyltransferase1e-0755.8
NC_002754:319315:320846320846321364519Sulfolobus solfataricus P2, complete genomehypothetical protein4e-0753.9