Pre_GI: BLASTP Hits

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Query: NC_010674:2185704:2195516 Clostridium botulinum B str. Eklund 17B, complete genome

Start: 2195516, End: 2195941, Length: 426

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum B str. Eklund 17B is a nonproteolytic botulism neurotoxin B strain. This strain was isolated from marine sediments taken off the coast of Washington, USA and was not associated with botulism. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010723:2082750:209038320903832090808426Clostridium botulinum E3 str. Alaska E43, complete genomeDhaG protein3e-56216
NC_003366:1122654:113323411332341133662429Clostridium perfringens str. 13, complete genomehypothetical protein3e-52203
NC_008261:1332864:134409813440981344526429Clostridium perfringens ATCC 13124, complete genomeDhaG protein4e-52202
NC_008262:1139500:115071011507101151138429Clostridium perfringens SM101, complete genomehypothetical protein4e-52202
NC_014632:1404000:141623914162391416658420Ilyobacter polytropus DSM 2926 chromosome, complete genomeATP:cob(I)alamin adenosyltransferase3e-30130
NC_009648:3803622:384911138491113849542432Klebsiella pneumoniae subsp. pneumoniae MGH 78578, complete genomehypothetical protein2e-28124
NC_014633:442755:4598114598114608661056Ilyobacter polytropus DSM 2926 plasmid pILYOP01, complete sequenceATP/cobalamin adenosyltransferase1e-1581.6
NC_010125:2884762:293636829363682936778411Gluconacetobacter diazotrophicus PAl 5, complete genomehypothetical protein6e-1579.3
NC_012488:1159463:117288711728871173882996Listeria monocytogenes Clip81459, complete genomePduO protein1e-1478.2
NC_013766:1202713:121483912148391215834996Listeria monocytogenes 08-5578 chromosome, complete genomeATP:cob(I)alamin adenosyltransferase protein PduO3e-1477
NC_019970:2080419:208445520844552085420966Thermoanaerobacterium thermosaccharolyticum M0795, complete genomeATP:cob(I)alamin adenosyltransferase2e-1374.3
NC_018000:1877183:189300618930061893422417Sinorhizobium fredii USDA 257 chromosome, complete genomehypothetical protein5e-1373.2
NC_004431:4270305:430980443098044310301498Escherichia coli CFT073, complete genomehypothetical protein3e-1270.5
NC_014654:1113116:112749411274941127910417Halanaerobium sp. 'sapolanicus' chromosome, complete genomeprotein of unknown function DUF3362e-1167.8
NC_011666:1923776:193884419388441939278435Methylocella silvestris BL2, complete genomeprotein of unknown function DUF3362e-1167.4
NC_010320:1949852:1953972195397219549731002Thermoanaerobacter sp. X514 chromosome, complete genomeATP--cobalamin adenosyltransferase4e-1166.6
NC_014538:985339:99937199937110003721002Thermoanaerobacter sp. X513 chromosome, complete genomeATP/cobalamin adenosyltransferase4e-1166.6
NC_016613:1877688:188092018809201881384465Vibrio sp. EJY3 chromosome 1, complete sequencehypothetical protein1e-1065.1
NC_018697:505915:517403517403517834432Cycloclasticus sp. P1 chromosome, complete genomeputative CmpX-like protein2e-0857.4
NC_013517:1055854:112091811209181121397480Sebaldella termitidis ATCC 33386, complete genomeprotein of unknown function DUF3361e-0755.1
NC_021171:2019755:203972920397292040163435Bacillus sp. 1NLA3E, complete genomehypothetical protein2e-0754.7
NC_002754:1061851:106391710639171064336420Sulfolobus solfataricus P2, complete genomehypothetical protein5e-0753.1
NC_012589:347020:353534353534353953420Sulfolobus islandicus L.S.2.15, complete genomeprotein of unknown function DUF3366e-0753.1
NC_017243:1813158:182684918268491827247399Brachyspira intermedia PWS/A chromosome, complete genomehypothetical protein9e-0752.4
NC_007973:1411714:143719814371981437647450Ralstonia metallidurans CH34 chromosome 1, complete sequenceprotein of unknown function DUF3366e-0649.7