Pre_GI: BLASTP Hits

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Query: NC_010674:2185704:2192530 Clostridium botulinum B str. Eklund 17B, complete genome

Start: 2192530, End: 2192838, Length: 309

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum B str. Eklund 17B is a nonproteolytic botulism neurotoxin B strain. This strain was isolated from marine sediments taken off the coast of Washington, USA and was not associated with botulism. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_016511:1212282:122236312223631222674312Propionibacterium acnes TypeIA2 P.acn31 chromosome, completePTS system, Lactose/Cellobiose specific IIB subunit7e-2199
NC_016516:1203000:121318012131801213491312Propionibacterium acnes TypeIA2 P.acn33 chromosome, completePTS system, Lactose/Cellobiose specific IIB subunit1e-2098.6
NC_016512:1211653:122173412217341222045312Propionibacterium acnes TypeIA2 P.acn17 chromosome, completePTS system, Lactose/Cellobiose specific IIB subunit1e-2098.6
NC_014039:1238500:124871012487101249021312Propionibacterium acnes SK137 chromosome, complete genomePTS system, Lactose/Cellobiose specific IIB subunit1e-2098.6
NC_006085:1234587:124667112466711246982312Propionibacterium acnes KPA171202, complete genomePTS system, lichenan-specific IIB component1e-1995.5
NC_014377:321949:337203337203337511309Thermosediminibacter oceani DSM 16646 chromosome, complete genomephosphotransferase system lactose/cellobiose-specific IIB subunit6e-1889.4
NC_012912:844339:850144850144850461318Dickeya zeae Ech1591, complete genomephosphotransferase system lactose/cellobiose-specific IIB subunit8e-1372.4
NC_013203:1406158:140751414075141407828315Atopobium parvulum DSM 20469, complete genomephosphotransferase system lactose/cellobiose- specific IIB subunit2e-1064.3
NC_014219:192555:196401196401196712312Bacillus selenitireducens MLS10 chromosome, complete genomephosphotransferase system lactose/cellobiose-specific IIB subunit8e-1062.4
NC_020181:1344259:134559613455961345907312Enterobacter aerogenes EA1509E, complete genomePTS system, cellobiose-specific IIB component2e-0961.6
NC_014377:1985714:199726619972661997592327Thermosediminibacter oceani DSM 16646 chromosome, complete genomephosphotransferase system lactose/cellobiose-specific IIB subunit7e-0959.3
NC_013716:4306695:434691043469104347224315Citrobacter rodentium ICC168, complete genomePTS system, cellobiose-specific IIb component1e-0858.2
NC_016845:2781438:278784727878472788170324Klebsiella pneumoniae subsp. pneumoniae HS11286 chromosome,lactose/cellobiose-specific PTS family enzyme IIB component1e-0858.2
NC_012731:2739964:274637427463742746697324Klebsiella pneumoniae NTUH-K2044 chromosome, complete genomelactose/cellobiose-specific PTS family enzyme IIB component1e-0858.2
NC_015634:526889:531224531224531547324Bacillus coagulans 2-6 chromosome, complete genomephosphotransferase system lactose/cellobiose-specific IIB subunit8e-0855.8
NC_020260:263528:264870264870265184315Cronobacter sakazakii Sp291, complete genomecellobiose-specific phosphotransferase enzyme IIB component9e-0855.5
NC_013282:3719500:373649737364973736811315Cronobacter turicensis, complete genomeCellobiose-specific phosphotransferase enzyme IIB component9e-0855.5
NC_009778:259241:260583260583260897315Enterobacter sakazakii ATCC BAA-894, complete genomehypothetical protein9e-0855.5
NC_008800:4488112:449114944911494491463315Yersinia enterocolitica subsp. enterocolitica 8081 chromosome,pts system, cellobiose-specific IIB component1e-0755.1
NC_016605:132253:137529137529137843315Pediococcus claussenii ATCC BAA-344 chromosome, complete genomePTS system, Lactose/Cellobiose specific IIB subunit4e-0753.1
NC_008261:2743942:276488027648802765209330Clostridium perfringens ATCC 13124, complete genomePTS system, lactose/cellobiose-specific IIB component2e-0650.8
NC_016023:729843:742662742662742985324Bacillus coagulans 36D1 chromosome, complete genomePTS system lactose/cellobiose-specific transporter subunit IIB3e-0650.8
NC_010582:1771591:177329017732901773607318Streptococcus pneumoniae CGSP14, complete genomePTS system, IIB component4e-0650.4
NC_002973:2701983:271090327109032711208306Listeria monocytogenes str. 4b F2365, complete genomePTS system, beta-glucoside-specific, IIB component4e-0650.1
NC_011660:2839201:285040128504012850706306Listeria monocytogenes HCC23 chromosome, complete genomePTS system lichenan-specific transporter subunit IIB4e-0650.1
NC_012488:2719955:272887527288752729180306Listeria monocytogenes Clip81459, complete genomecellobiose phosphotransferase enzyme IIB component4e-0650.1
NC_003212:2837366:284754828475482847853306Listeria innocua Clip11262, complete genomehypothetical protein4e-0650.1
NC_013766:171889:183986183986184291306Listeria monocytogenes 08-5578 chromosome, complete genomehypothetical protein4e-0650.1
NC_013768:171889:183986183986184291306Listeria monocytogenes 08-5923, complete genomehypothetical protein4e-0650.1
NC_014650:1410790:141634414163441416667324Geobacillus sp. Y4.1MC1 chromosome, complete genomephosphotransferase system lactose/cellobiose-specific subunit IIB5e-0649.7
NC_008563:1651270:166317316631731663484312Escherichia coli APEC O1, complete genomePTS system, cellobiose-specific IIB component6e-0649.7
NC_013891:2643085:265318026531802653485306Listeria seeligeri serovar 1/2b str. SLCC3954, complete genomePTS system, beta-glucoside-specific, IIB component9e-0648.9