Pre_GI: BLASTP Hits

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Query: NC_010674:2185704:2189819 Clostridium botulinum B str. Eklund 17B, complete genome

Start: 2189819, End: 2191132, Length: 1314

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum B str. Eklund 17B is a nonproteolytic botulism neurotoxin B strain. This strain was isolated from marine sediments taken off the coast of Washington, USA and was not associated with botulism. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_014410:2329838:2346898234689823482081311Thermoanaerobacterium thermosaccharolyticum DSM 571 chromosome,glycoside hydrolase family 41e-157556
NC_014377:321949:3429903429903443091320Thermosediminibacter oceani DSM 16646 chromosome, complete genome6-phospho-beta-glucosidase1e-148526
NC_014206:3391352:3396381339638133977241344Geobacillus sp. C56-T3 chromosome, complete genomeglycoside hydrolase family protein7e-146517
NC_009848:720510:7454127454127467401329Bacillus pumilus SAFR-032, complete genome6-phospho-beta-glucosidase1e-141503
NC_019908:1467000:1488605148860514899361332Brachyspira pilosicoli P43/6/78 chromosome, complete genome6-phospho-beta-glucosidase1e-122440
NC_018607:2375344:2396322239632223976531332Brachyspira pilosicoli B2904 chromosome, complete genome6-phospho-beta-glucosidase2e-122439
NC_014966:1668822:1672832167283216741451314Vibrio vulnificus MO6-24/O chromosome II, complete sequence6-phospho-beta-glucosidase2e-119429
NC_014219:192555:1934311934311947561326Bacillus selenitireducens MLS10 chromosome, complete genomeglycoside hydrolase family 45e-113407
NC_020291:6310000:6332080633208063334171338Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomephospho-alpha-glucosidase PagL1e-50200
NC_007333:3244572:3248439324843932498211383Thermobifida fusca YX, complete genome6-phospho-beta-glucosidase6e-50198
NC_003366:255480:2554802554802568051326Clostridium perfringens str. 13, complete genomemaltose-6'-phosphate glucosidase2e-44180
NC_019978:2532640:2549035254903525503601326Halobacteroides halobius DSM 5150, complete genomefamily 4 glycosyl hydrolase, alpha-galactosidase/6-phospho-beta-glucosidase2e-44180
NC_016816:2073677:2091554209155420928761323Pantoea ananatis LMG 5342, complete genome6-phospho-alpha-glucosidase AglB1e-42174
NC_015389:1375315:1376936137693613783001365Coriobacterium glomerans PW2 chromosome, complete genomeglycoside hydrolase family 46e-42172
NC_013171:497499:5178595178595191871329Anaerococcus prevotii DSM 20548, complete genomeglycoside hydrolase family 43e-41169
NC_010516:359310:3671073671073684411335Clostridium botulinum B1 str. Okra, complete genomemaltose-6'-phosphate glucosidase2e-40166
NC_016023:1959255:1960885196088519622101326Bacillus coagulans 36D1 chromosome, complete genomeglycoside hydrolase family protein6e-40165
NC_015567:2420169:2423408242340824247331326Serratia sp. AS9 chromosome, complete genomeMaltose-6'-phosphate glucosidase9e-40164
NC_015566:2420287:2423526242352624248511326Serratia sp. AS12 chromosome, complete genomeMaltose-6'-phosphate glucosidase9e-40164
NC_009848:720510:7409947409947423221329Bacillus pumilus SAFR-032, complete genomemaltose-6'-phosphate glucosidase2e-39163
NC_017191:754453:7799227799227812711350Bacillus amyloliquefaciens XH7 chromosome, complete genomemaltose-6'-phosphate glucosid GlvA2e-37157
NC_017190:794820:8202898202898216381350Bacillus amyloliquefaciens LL3 chromosome, complete genome6-phospho-alpha-glucosidase2e-37157
NC_014551:809025:8344988344988358471350Bacillus amyloliquefaciens DSM 7, complete genome6-phospho-alpha-glucosidase2e-37157
NC_017188:753039:7785087785087798541347Bacillus amyloliquefaciens TA208 chromosome, complete genome6-phospho-alpha-glucosidase3e-36152
NC_011898:1218500:1244410124441012458791470Clostridium cellulolyticum H10, complete genomeglycoside hydrolase family 42e-33144
NC_015663:1356982:1356982135698213583611380Enterobacter aerogenes KCTC 2190 chromosome, complete genomeputative glycoside hydrolase2e-33143
NC_019978:2532640:2532640253264025339351296Halobacteroides halobius DSM 5150, complete genomefamily 4 glycosyl hydrolase, alpha-galactosidase/6-phospho-beta-glucosidase7e-33142
NC_021066:3703725:3721620372162037229661347Raoultella ornithinolytica B6, complete genomealpha-galactosidase2e-31136
NC_016935:2069562:2093525209352520948261302Paenibacillus mucilaginosus 3016 chromosome, complete genomeMelA2 protein2e-30133
NC_015690:1542061:1566197156619715674981302Paenibacillus mucilaginosus KNP414 chromosome, complete genomeMelA22e-30133
NC_019897:1577015:1577015157701515785321518Thermobacillus composti KWC4 chromosome, complete genomefamily 4 glycosyl hydrolase, alpha-galactosidase/6-phospho-beta-glucosidase6e-30132
NC_014364:815346:8672748672748686201347Spirochaeta smaragdinae DSM 11293 chromosome, complete genomeglycoside hydrolase family 44e-30132
NC_017138:2293576:2298060229806022993821323Bacillus megaterium WSH-002 chromosome, complete genomealpha-galactosidase2e-29130
NC_015675:2567000:2588422258842225898881467Mesorhizobium opportunistum WSM2075 chromosome, complete genomeglycoside hydrolase family protein4e-29129
NC_014618:3482053:3491748349174834931001353Enterobacter cloacae SCF1 chromosome, complete genomeglycoside hydrolase7e-29128
NC_014923:2439197:2461260246126024627261467Mesorhizobium ciceri biovar biserrulae WSM1271 chromosome, completeglycoside hydrolase family 42e-28127
NC_013205:854983:8693228693228706201299Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446,glycoside hydrolase family 41e-27124
NC_011898:3973627:3987858398785839891831326Clostridium cellulolyticum H10, complete genomeglycoside hydrolase family 42e-27123
NC_019973:2417000:2438139243813924395301392Mesorhizobium australicum WSM2073, complete genomefamily 4 glycosyl hydrolase, alpha-galactosidase/6-phospho-beta-glucosidase4e-27122
NC_015520:2859820:2874099287409928754211323Mahella australiensis 50-1 BON chromosome, complete genomealpha-galactosidase4e-25116
NC_006322:1119471:1149016114901611503141299Bacillus licheniformis ATCC 14580, complete genomeMelA3e-25116
NC_006270:1119000:1148162114816211494601299Bacillus licheniformis ATCC 14580, complete genomealpha-D-galactoside galactohydrolase, Glycoside Hydrolase Family 4,MelA3e-25116
NC_010998:111052:1148961148961162661371Rhizobium etli CIAT 652 plasmid pA, complete sequencealpha-galactosidase protein9e-25115
NC_010067:3247169:3262599326259932639541356Salmonella enterica subsp. arizonae serovar 62:z4,z23:--, completehypothetical protein9e-25115
NC_010001:986500:9932859932859946071323Clostridium phytofermentans ISDg, complete genomeglycoside hydrolase family 41e-22108
NC_010001:3473425:3490641349064134921041464Clostridium phytofermentans ISDg, complete genomeglycoside hydrolase family 43e-21103
NC_014479:736102:7532317532317545741344Bacillus subtilis subsp. spizizenii str. W23 chromosome, completeputative glycosidase5e-1995.9
UCMB5137:303641:3227753227753241211347Bacillus atrophaeus UCMB-5137putative glycosidase1e-1894.7
NC_017195:742298:7604767604767618161341Bacillus subtilis subsp. subtilis str. RO-NN-1 chromosome, completeputative glucosidase LplD2e-1894
NC_014639:227118:2442672442672456131347Bacillus atrophaeus 1942 chromosome, complete genomeglycosidase6e-1892.4
CP002207:227118:2442672442672456131347Bacillus atrophaeus 1942, complete genomeputative glycosidase6e-1892.4
NC_016047:876875:8959588959588972981341Bacillus subtilis subsp. spizizenii TU-B-10 chromosome, completeputative glucosidase LplD1e-1791.7
NC_000964:764118:7822957822957836351341Bacillus subtilis subsp. subtilis str. 168, complete genomehydrolytic enzyme1e-1687.8
NC_000853:1071078:1083673108367310850731401Thermotoga maritima MSB8, complete genomealpha-glucosidase, putative2e-1687.4
NC_014976:2981777:3000854300085430021941341Bacillus subtilis BSn5 chromosome, complete genomeputative glycosidase2e-1687.4
NC_020244:783125:8002798002798016191341Bacillus subtilis XF-1, complete genomeputative glycosidase2e-1687
NC_009486:155651:1723781723781737931416Thermotoga petrophila RKU-1 chromosome, complete genomeglycoside hydrolase family protein7e-1685.5
NC_013642:545464:5481755481755495901416Thermotoga naphthophila RKU-10, complete genomeglycoside hydrolase family 47e-1685.5
NC_000853:771746:7744577744577758721416Thermotoga maritima MSB8, complete genomealpha-glucosidase, putative7e-1685.5
NC_013642:574673:5791975791975806391443Thermotoga naphthophila RKU-10, complete genomeglycoside hydrolase family 41e-1481.6
NC_013526:65495:8294182941842871347Thermobaculum terrenum ATCC BAA-798 chromosome 2, complete genomeglycoside hydrolase family 43e-1377
NC_010003:123297:1273491273491288031455Petrotoga mobilis SJ95, complete genomeglycoside hydrolase family 44e-1376.6
NC_015634:2595500:262026226202622621053792Bacillus coagulans 2-6 chromosome, complete genomeMaltose-6'-phosphate glucosidase9e-0652