Pre_GI: BLASTP Hits

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Query: NC_010674:2185704:2189492 Clostridium botulinum B str. Eklund 17B, complete genome

Start: 2189492, End: 2189794, Length: 303

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum B str. Eklund 17B is a nonproteolytic botulism neurotoxin B strain. This strain was isolated from marine sediments taken off the coast of Washington, USA and was not associated with botulism. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_019908:1467000:148826614882661488562297Brachyspira pilosicoli P43/6/78 chromosome, complete genomePTS system transporter subunit IIA5e-1993.2
NC_018607:2375344:239598323959832396303321Brachyspira pilosicoli B2904 chromosome, complete genomePTS system transporter subunit IIA6e-1992.8
NC_014410:2329838:235151423515142351843330Thermoanaerobacterium thermosaccharolyticum DSM 571 chromosome,phosphotransferase system PTS lactose/cellobiose-specific IIA subunit1e-1788.2
NC_006085:1234587:124829812482981248618321Propionibacterium acnes KPA171202, complete genomePTS cellobiose-specific component IIA5e-1786.3
NC_016516:1203000:121476212147621215127366Propionibacterium acnes TypeIA2 P.acn33 chromosome, completePTS system, Lactose/Cellobiose specific IIA subunit5e-1786.3
NC_016512:1211653:122331612233161223681366Propionibacterium acnes TypeIA2 P.acn17 chromosome, completePTS system, Lactose/Cellobiose specific IIA subunit5e-1786.3
NC_016511:1212282:122394512239451224310366Propionibacterium acnes TypeIA2 P.acn31 chromosome, completePTS system, Lactose/Cellobiose specific IIA subunit5e-1786.3
NC_014039:1238500:125033412503341250657324Propionibacterium acnes SK137 chromosome, complete genomePTS system, Lactose/Cellobiose specific IIA subunit8e-1785.9
NC_014650:1410790:141599914159991416310312Geobacillus sp. Y4.1MC1 chromosome, complete genomephosphotransferase system PTS lactose/cellobiose-specific subunit IIA1e-1582
NC_017190:1196356:122679112267911227105315Bacillus amyloliquefaciens LL3 chromosome, complete genomePTS system lactose-specific transporter subunit IIA1e-1581.6
NC_014551:1279229:130965213096521309966315Bacillus amyloliquefaciens DSM 7, complete genomeLacF1e-1581.6
NC_014377:1985714:199560019956001995917318Thermosediminibacter oceani DSM 16646 chromosome, complete genomephosphotransferase system PTS lactose/cellobiose-specific IIA subunit2e-1581.3
NC_014377:321949:338813338813339178366Thermosediminibacter oceani DSM 16646 chromosome, complete genomephosphotransferase system PTS lactose/cellobiose-specific IIA subunit3e-1580.5
NC_016641:2291363:230698523069852307332348Paenibacillus terrae HPL-003 chromosome, complete genomephosphotransferase system PTS lactose/cellobiose-specific IIA subunit6e-1579.7
NC_019978:2532640:255039025503902550734345Halobacteroides halobius DSM 5150, complete genomephosphotransferase system cellobiose-specific component IIA1e-1478.6
NC_015634:526889:530761530761531093333Bacillus coagulans 2-6 chromosome, complete genomephosphotransferase system PTS lactose/cellobiose-specific IIA subunit4e-1476.6
NC_020291:5409587:542670654267065427008303Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomephosphotransferase system PTS lactose/cellobiose-specific IIA subunit8e-1475.9
NC_016023:729843:743119743119743445327Bacillus coagulans 36D1 chromosome, complete genomePTS system lactose/cellobiose-specific transporter subunit IIA9e-1475.5
NC_013768:171889:182204182204182506303Listeria monocytogenes 08-5923, complete genomehypothetical protein1e-1375.1
NC_013766:171889:182204182204182506303Listeria monocytogenes 08-5578 chromosome, complete genomehypothetical protein1e-1375.1
NC_011660:2839201:284861928486192848921303Listeria monocytogenes HCC23 chromosome, complete genomePTS system lichenan-specific transporter subunit IIA1e-1375.1
NC_003212:2837366:284933428493342849636303Listeria innocua Clip11262, complete genomehypothetical protein1e-1375.1
NC_003210:2749538:275939027593902759692303Listeria monocytogenes EGD-e, complete genomehypothetical protein1e-1375.1
NC_013891:2643085:265496726549672655269303Listeria seeligeri serovar 1/2b str. SLCC3954, complete genomePTS system, beta-glucoside-specific, IIA component1e-1375.1
NC_002973:2701983:271268727126872712989303Listeria monocytogenes str. 4b F2365, complete genomePTS system, beta-glucoside-specific, IIA component1e-1375.1
NC_018265:75658:897058970590028324Melissococcus plutonius DAT561 plasmid 1, complete sequencephosphotransferase system PTS protein5e-1373.2
NC_013716:4306695:434384643438464344148303Citrobacter rodentium ICC168, complete genomeputative PTS system protein, component IIA6e-1372.8
NC_008262:2824503:283540728354072835724318Clostridium perfringens SM101, complete genomephosphotransferase system enzyme II, ptcA6e-1372.8
NC_008800:4488112:449283044928304493132303Yersinia enterocolitica subsp. enterocolitica 8081 chromosome,putative phosphotransferase protein7e-1372.8
NC_010582:1771591:177295617729561773273318Streptococcus pneumoniae CGSP14, complete genomephosphotransferase system (PTS) cellobiose-specific component IIA, putative1e-1272
NC_016845:2781438:278752327875232787837315Klebsiella pneumoniae subsp. pneumoniae HS11286 chromosome,putative lactose/cellobiose-specific PTS family enzyme IIA component2e-1271.2
NC_012731:2739964:274605027460502746364315Klebsiella pneumoniae NTUH-K2044 chromosome, complete genomeputative lactose/cellobiose-specific PTS family enzyme IIA component2e-1271.2
NC_020995:3252500:325800132580013258330330Enterococcus casseliflavus EC20, complete genomehypothetical protein2e-1271.2
NC_008800:1090000:109322210932221093569348Yersinia enterocolitica subsp. enterocolitica 8081 chromosome,PTS system N,N'-diacetylchitobiose-specific transporter subunit IIA3e-1167.4
NC_015224:3587500:360920236092023609549348Yersinia enterocolitica subsp. palearctica 105.5R(r) chromosome,N,N'-diacetylchitobiose-specific PTS system transporter subunit IIA7e-1165.9
NC_006155:3456488:346158134615813461928348Yersinia pseudotuberculosis IP 32953, complete genomePTS system, cellobiose-specific IIA component1e-1065.1
NC_005810:2739878:275351927535192753866348Yersinia pestis biovar Microtus str. 91001, complete genomeN,N'-diacetylchitobiose-specific PTS system transporter subunit IIA1e-1065.1
NC_008149:1317109:133075513307551331102348Yersinia pestis Nepal516, complete genomePTS system, cellobiose-specific IIA component1e-1065.1
NC_010465:1273000:128474812847481285095348Yersinia pseudotuberculosis YPIII, complete genomephosphotransferase system PTS lactose/cellobiose-specific IIA subunit1e-1065.1
NC_008150:2681327:269497326949732695320348Yersinia pestis Antiqua, complete genomePTS system, cellobiose-specific IIA component1e-1065.1
NC_010634:3368000:337523933752393375586348Yersinia pseudotuberculosis PB1/+, complete genomephosphotransferase system PTS lactose/cellobiose-specific IIA subunit1e-1065.1
NC_004088:1387276:140085614008561401203348Yersinia pestis KIM, complete genomePEP-dependent phosphotransferase IIA component for cellobiose, arbutin, and salicin1e-1065.1
NC_003143:2992295:300594130059413006288348Yersinia pestis CO92, complete genomePTS system, cellobiose-specific IIA component1e-1065.1
NC_009381:1783886:179015117901511790498348Yersinia pestis Pestoides F chromosome, complete genomePTS system N,N'-diacetylchitobiose-specific transporter subunit IIA1e-1065.1
NC_014029:3047506:306115230611523061499348Yersinia pestis Z176003 chromosome, complete genomePTS system cellobiose-specific transporter subunit IIA1e-1065.1
NC_017154:2999841:300493430049343005281348Yersinia pestis D106004 chromosome, complete genomePTS system cellobiose-specific transporter subunit IIA1e-1065.1
NC_017160:2976683:298612729861272986474348Yersinia pestis D182038 chromosome, complete genomePTS system cellobiose-specific transporter subunit IIA1e-1065.1
NC_017168:2751027:275612027561202756467348Yersinia pestis A1122 chromosome, complete genomePTS system N,N'-diacetylchitobiose-specific transporter subunit IIA1e-1065.1
NC_017265:3063016:306810930681093068456348Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,PTS system cellobiose-specific transporter subunit IIA1e-1065.1
NC_009708:1284555:129636912963691296716348Yersinia pseudotuberculosis IP 31758 chromosome, complete genomePTS system N,N'-diacetylchitobiose-specific transporter subunit IIA2e-1064.7
NC_016605:132253:137932137932138255324Pediococcus claussenii ATCC BAA-344 chromosome, complete genomePTS system, Lactose/Cellobiose specific IIA subunit2e-1064.3
NC_014219:192555:196060196060196383324Bacillus selenitireducens MLS10 chromosome, complete genomephosphotransferase system PTS lactose/cellobiose-specific IIA subunit5e-1063.2
NC_008563:1651270:166139716613971661711315Escherichia coli APEC O1, complete genomePTS system, cellobiose-specific IIA component9e-1062.4
NC_014376:6296:127961279613173378Clostridium saccharolyticum WM1 chromosome, complete genomephosphotransferase system PTS lactose/cellobiose-specific IIA subunit1e-0962
NC_009800:1632585:164027716402771640588312Escherichia coli HS, complete genomePTS system, lactose/cellobiose-specific family, IIA component3e-0960.5
NC_010498:1615980:162536416253641625675312Escherichia coli SMS-3-5, complete genomePTS system lactose/cellobiose-specific family IIA subunit3e-0960.5
NC_012912:1200000:121547512154751215792318Dickeya zeae Ech1591, complete genomephosphotransferase system PTS lactose/cellobiose-specific IIA subunit4e-0960.1
CU928160:1625535:163418716341871634501315Escherichia coli IAI1 chromosome, complete genomeputative phosphotransferase system PTS, lactose/cellobiose-specific IIA subunit5e-0959.7
NC_011415:1715644:172429617242961724610315Escherichia coli SE11 chromosome, complete genomePTS system cellobiose-specific IIA component5e-0959.7
NC_011741:1625535:163418716341871634501315Escherichia coli IAI1 chromosome, complete genomeputative phosphotransferase system PTS, lactose/cellobiose-specific IIA subunit5e-0959.7
CP002185:1727493:173614517361451736456312Escherichia coli W, complete genomePTS system cellobiose-specific IIA component5e-0959.7
CP002516:2361628:236939923693992369710312Escherichia coli KO11, complete genomephosphotransferase system PTS lactose/cellobiose-specific IIA subunit5e-0959.7
NC_016902:2361628:236939923693992369710312Escherichia coli KO11FL chromosome, complete genomephosphotransferase system PTS lactose/cellobiose-specific IIA subunit5e-0959.7
NC_016641:373623:386416386416386763348Paenibacillus terrae HPL-003 chromosome, complete genomePTS system transporter subunit IIA7e-0959.3
NC_006177:1060428:106957010695701069917348Symbiobacterium thermophilum IAM 14863, complete genomePTS system cellobiose-specific IIA component7e-0959.3
NC_012912:844339:846754846754847080327Dickeya zeae Ech1591, complete genomephosphotransferase system PTS lactose/cellobiose-specific IIA subunit1e-0858.2
NC_012917:3241196:329094732909473291270324Pectobacterium carotovorum subsp. carotovorum PC1, complete genomephosphotransferase system PTS lactose/cellobiose-specific IIA subunit1e-0652