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Query: NC_010674:1:4323 Clostridium botulinum B str. Eklund 17B, complete genome

Start: 4323, End: 4583, Length: 261

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum B str. Eklund 17B is a nonproteolytic botulism neurotoxin B strain. This strain was isolated from marine sediments taken off the coast of Washington, USA and was not associated with botulism. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010723:1:427542754535261Clostridium botulinum E3 str. Alaska E43, complete genomehypothetical protein1e-43174
NC_020291:1:423042304490261Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomehypothetical protein2e-38157
NC_003366:1:466546654925261Clostridium perfringens str. 13, complete genomehypothetical protein8e-38155
NC_008261:1:466646664926261Clostridium perfringens ATCC 13124, complete genomehypothetical protein8e-38155
NC_008262:1:449044904750261Clostridium perfringens SM101, complete genomehypothetical protein8e-38155
NC_012563:1:427942794542264Clostridium botulinum A2 str. Kyoto, complete genomehypothetical protein5e-37152
NC_010520:1:412741274390264Clostridium botulinum A3 str. Loch Maree, complete genomehypothetical protein5e-37152
NC_010516:1:415041504413264Clostridium botulinum B1 str. Okra, complete genomehypothetical protein5e-37152
NC_009495:1:412241224385264Clostridium botulinum A str. ATCC 3502 chromosome, complete genomehypothetical protein5e-37152
NC_009697:1:412241224385264Clostridium botulinum A str. ATCC 19397 chromosome, completehypothetical protein5e-37152
NC_009698:1:412241224385264Clostridium botulinum A str. Hall chromosome, complete genomehypothetical protein5e-37152
NC_009699:1:412341234386264Clostridium botulinum F str. Langeland chromosome, complete genomehypothetical protein5e-37152
NC_012658:1:428642864549264Clostridium botulinum Ba4 str. 657 chromosome, complete genomehypothetical protein5e-37152
NC_017297:1:412341234386264Clostridium botulinum F str. 230613 chromosome, complete genomehypothetical protein5e-37152
NC_008593:2527064:254311225431122543381270Clostridium novyi NT, complete genomehypothetical protein3e-35147
NC_021182:1:455845584821264Clostridium pasteurianum BC1, complete genomehypothetical protein8e-35145
NC_014393:1:455645564819264Clostridium cellulovorans 743B chromosome, complete genomehypothetical protein3e-34143
NC_015425:2752482:276855427685542768823270Clostridium botulinum BKT015925 chromosome, complete genomehypothetical protein7e-34142
NC_003030:1:448944894821333Clostridium acetobutylicum ATCC 824, complete genomeUncharacterized small conserved protein, ortholog of YAAB B.subtilis1e-33141
NC_015687:1:448944894821333Clostridium acetobutylicum DSM 1731 chromosome, complete genomehypothetical protein1e-33141
NC_009706:1:414741474410264Clostridium kluyveri DSM 555 chromosome, complete genomehypothetical protein5e-33139
NC_011837:1:414141414410270Clostridium kluyveri NBRC 12016, complete genomehypothetical protein5e-33139
NC_014328:1:423642364499264Clostridium ljungdahlii ATCC 49587 chromosome, complete genomehypothetical protein1e-31134
NC_010718:1:521852185517300Natranaerobius thermophilus JW/NM-WN-LF, complete genomehypothetical protein1e-1168.2
NC_009922:1:442244224757336Alkaliphilus oremlandii OhILAs, complete genomeconserved hypothetical protein3e-1167
NC_018664:1:428942894576288Clostridium acidurici 9a chromosome, complete genomehypothetical protein6e-1166.2
NC_015565:2879603:406040604320261Desulfotomaculum carboxydivorans CO-1-SRB chromosome, completehypothetical protein2e-1064.7
NC_014654:1:424142414501261Halanaerobium sp. 'sapolanicus' chromosome, complete genomehypothetical protein6e-1062.8
NC_021184:1:447544754708234Desulfotomaculum gibsoniae DSM 7213, complete genomeprotein of unknown function (DUF370)7e-1062.4
NC_014378:525717:532553255582258Acetohalobium arabaticum DSM 5501 chromosome, complete genomehypothetical protein5e-0959.7
NC_014378:4428:532553255582258Acetohalobium arabaticum DSM 5501 chromosome, complete genomehypothetical protein5e-0959.7
NC_014098:3372000:444444444701258Bacillus tusciae DSM 2912 chromosome, complete genomehypothetical protein8e-0959.3
NC_014152:1:414141414395255Thermincola sp. JR, complete genomehypothetical protein9e-0855.8
NC_015519:2739347:465446544920267Tepidanaerobacter sp. Re1 chromosome, complete genomehypothetical protein5e-0753.1
NC_013895:66641:939649396494242279Clostridiales genomosp. BVAB3 str. UPII9-5 chromosome, completehypothetical protein2e-0650.8