Pre_GI: BLASTP Hits

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Query: NC_010674:1:20244 Clostridium botulinum B str. Eklund 17B, complete genome

Start: 20244, End: 20762, Length: 519

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum B str. Eklund 17B is a nonproteolytic botulism neurotoxin B strain. This strain was isolated from marine sediments taken off the coast of Washington, USA and was not associated with botulism. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_020291:1:181381813818632495Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomeacetyltransferase, ribosomal protein N-acetylase5e-40163
NC_018645:4104302:411955641195564120188633Desulfobacula toluolica Tol2, complete genomeN-acetyltransferase GCN52e-1994.7
NC_016751:1604048:162075316207531621283531Marinitoga piezophila KA3 chromosome, complete genomeacetyltransferase, ribosomal protein N-acetylase2e-1891.3
NC_015555:1450704:145399514539951454558564Thermoanaerobacterium xylanolyticum LX-11 chromosome, completeGCN5-related N-acetyltransferase4e-1684.3
NC_014410:1527405:153164115316411532192552Thermoanaerobacterium thermosaccharolyticum DSM 571 chromosome,GCN5-related N-acetyltransferase6e-1580.1
NC_019970:1457794:146708914670891467640552Thermoanaerobacterium thermosaccharolyticum M0795, complete genomeacetyltransferase, ribosomal protein N-acetylase6e-1580.1
NC_015690:4469775:451824245182424518763522Paenibacillus mucilaginosus KNP414 chromosome, complete genomeGNAT family acetyltransferase1e-1479.3
NC_016641:3711972:371482937148293715392564Paenibacillus terrae HPL-003 chromosome, complete genomeacetyltransferase2e-1479
NC_016582:9664000:967312196731219673612492Streptomyces bingchenggensis BCW-1 chromosome, complete genomeN-acetyltransferase GCN52e-1478.2
NC_016935:4233223:427406842740684274589522Paenibacillus mucilaginosus 3016 chromosome, complete genomeGNAT family acetyltransferase6e-1477
NC_013406:2207520:221452822145282215067540Paenibacillus sp. Y412MC10 chromosome, complete genomeGCN5-like N-acetyltransferase1e-1376.3
NC_015660:1918307:192669519266951927294600Geobacillus thermoglucosidasius C56-YS93 chromosome, completeGCN5-like N-acetyltransferase1e-1375.9
NC_015958:1465631:146980414698041470373570Thermoanaerobacter wiegelii Rt8.B1 chromosome, complete genomeGCN5-like N-acetyltransferase1e-1375.5
NC_020210:1704500:175594217559421756541600Geobacillus sp. GHH01, complete genomeGCN5-related N-acetyltransferase5e-1373.6
NC_016584:487613:501601501601502173573Desulfosporosinus orientis DSM 765 chromosome, complete genomeacetyltransferase, ribosomal protein N-acetylase1e-1272.4
NC_016593:2447938:245923224592322459738507Geobacillus thermoleovorans CCB_US3_UF5 chromosome, completeN-acetyltransferase GCN51e-1169.3
NC_014209:1363151:138833813883381388895558Thermoanaerobacter mathranii subsp. mathranii str. A3 chromosome,GCN5-related N-acetyltransferase1e-1169.3
NC_011999:936500:938383938383938880498Macrococcus caseolyticus JCSC5402, complete genomespermidine acetyltransferase2e-1168.9
NC_009615:3993187:400082740008274001762936Parabacteroides distasonis ATCC 8503 chromosome, complete genomehypothetical protein3e-1167.8
NC_004461:1:356513565136148498Staphylococcus epidermidis ATCC 12228, complete genomespermidine acetyltransferase6e-1166.6
NC_002506:324552:324552324552325088537Vibrio cholerae O1 biovar eltor str. N16961 chromosome II, completeacetyltransferase, putative2e-1065.1
NC_002506:370629:383932383932384468537Vibrio cholerae O1 biovar eltor str. N16961 chromosome II, completeacetyltransferase, putative2e-1065.1
NC_016446:49618:496184961850154537Vibrio cholerae O1 str. 2010EL-1786 chromosome 2, completehypothetical protein2e-1065.1
NC_016945:324519:324519324519325055537Vibrio cholerae IEC224 chromosome II, complete sequencehypothetical protein2e-1065.1
NC_016945:370471:383751383751384287537Vibrio cholerae IEC224 chromosome II, complete sequencehypothetical protein2e-1065.1
NC_015500:900807:913193913193913717525Treponema brennaborense DSM 12168 chromosome, complete genomeGCN5-related N-acetyltransferase3e-1064.7
NC_010184:3213347:323012932301293230680552Bacillus weihenstephanensis KBAB4, complete genomeGCN5-related N-acetyltransferase9e-1062.8
NC_012225:2834642:283693328369332837499567Brachyspira hyodysenteriae WA1, complete genomeacetyltransferase, RimL family2e-0962
NC_016616:49388:728127281273354543Dechlorosoma suillum PS chromosome, complete genomeacetyltransferase, ribosomal protein N-acetylase2e-0961.6
NC_019974:298523:315734315734316261528Natronococcus occultus SP4, complete genomeacetyltransferase, ribosomal protein N-acetylase6e-0960.5
NC_015953:4385419:440406044040604404602543Streptomyces sp. SirexAA-E chromosome, complete genomeGCN5-like N-acetyltransferase1e-0858.9
NC_011772:2860000:287941728794172879956540Bacillus cereus G9842, complete genomebifunctional AAC/APH1e-0858.9
NC_013061:4712051:473792847379284738473546Pedobacter heparinus DSM 2366, complete genomeGCN5-related N-acetyltransferase2e-0858.9
NC_007651:72952:864438644387027585Burkholderia thailandensis E264 chromosome I, complete sequencespermidine n(1)-acetyltransferase2e-0858.9
NC_016048:4163225:418160841816084182150543Oscillibacter valericigenes Sjm18-20, complete genomeputative acetyltransferase2e-0858.5
NC_011773:2782465:279979627997962800329534Bacillus cereus AH820 chromosome, complete genomeGNAT family acetyltransferase2e-0858.5
NC_016884:587789:606631606631607206576Sulfobacillus acidophilus DSM 10332 chromosome, complete genomeN-acetyltransferase GCN53e-0858.2
NC_015757:1973925:198337819833781983953576Sulfobacillus acidophilus TPY chromosome, complete genomehypothetical protein3e-0858.2
NC_009718:1024000:103602010360201036463444Fervidobacterium nodosum Rt17-B1, complete genomeGCN5-related N-acetyltransferase3e-0858.2
NC_009455:273519:313092313092313727636Dehalococcoides sp. BAV1 chromosome, complete genomeN-acetyltransferase GCN54e-0857.8
NC_008600:2792584:280981728098172810350534Bacillus thuringiensis str. Al Hakam, complete genomeacetyltransferase, GNAT family4e-0857.8
NC_016779:2693790:271117727111772711710534Bacillus cereus F837/76 chromosome, complete genomeisochorismatase4e-0857.8
NC_021177:7870464:789681178968117897308498Streptomyces fulvissimus DSM 40593, complete genomeGCN5-related N-acetyltransferase3e-0857.8
NC_006138:23902:408104081041337528Desulfotalea psychrophila LSv54, complete genomesimilar to acetyltransferase3e-0857.8
NC_020418:1841138:184295518429551843458504Morganella morganii subsp. morganii KT, complete genomeAcetyltransferase (GNAT) family protein4e-0857.4
NC_009076:106807:123226123226123786561Burkholderia pseudomallei 1106a chromosome I, complete sequencediamine N-acetyltransferase5e-0857.4
NC_009074:94000:109990109990110550561Burkholderia pseudomallei 668 chromosome I, complete sequencediamine N-acetyltransferase5e-0857.4
NC_011969:2706000:2723969272396927250481080Bacillus cereus Q1 chromosome, complete genomeGNAT family acetyltransferase6e-0857
NC_015382:172213:174767174767175312546Burkholderia gladioli BSR3 plasmid bgla_1p, complete sequenceputative acetyltransferase6e-0857
NC_017095:1333810:134802813480281348519492Fervidobacterium pennivorans DSM 9078 chromosome, complete genomeacetyltransferase, ribosomal protein N-acetylase5e-0857
NC_016935:3103430:311560331156033116553951Paenibacillus mucilaginosus 3016 chromosome, complete genomeN-acetyltransferase GCN57e-0856.6
NC_015425:2690448:272659327265932727531939Clostridium botulinum BKT015925 chromosome, complete genomeputative ribosomal-protein (S5)-alanine N-acetyltransferase8e-0856.6
NC_004663:1365429:136601613660161366555540Bacteroides thetaiotaomicron VPI-5482, complete genomeacetyltransferase1e-0756.2
NC_003997:2715623:273398127339812734514534Bacillus anthracis str. Ames, complete genomeacetyltransferase, GNAT family1e-0756.2
NC_005945:2716000:273444427344442734977534Bacillus anthracis str. Sterne, complete genomeacetyltransferase, GNAT family1e-0756.2
NC_007530:2716885:273410927341092734642534Bacillus anthracis str. 'Ames Ancestor', complete genomeacetyltransferase, gnat family1e-0756.2
NC_012659:2715651:273400927340092734542534Bacillus anthracis str. A0248, complete genomeacetyltransferase, GNAT family1e-0756.2
NC_014614:2359046:236737223673722367950579Clostridium sticklandii, complete genomeGCN5-related N-acetyltransferase9e-0856.2
NC_006322:1959918:196312119631211963663543Bacillus licheniformis ATCC 14580, complete genomehypothetical protein9e-0856.2
NC_003909:2798622:2815395281539528164741080Bacillus cereus ATCC 10987, complete genomeacetyltransferase, GNAT family9e-0856.2
NC_017208:2942554:296167829616782962217540Bacillus thuringiensis serovar chinensis CT-43 chromosome, complete2''-aminoglycoside phosphotransferase1e-0755.8
NC_008508:1382036:139140813914081391953546Leptospira borgpetersenii serovar Hardjo-bovis L550 chromosome 1,Acetyltransferase1e-0755.8
NC_008510:1339926:134928913492891349834546Leptospira borgpetersenii serovar Hardjo-bovis JB197 chromosome 1,Acetyltransferase1e-0755.8
NC_006274:2779380:279803327980332798566534Bacillus cereus E33L, complete genomeacetyltransferase, GNAT family1e-0755.8
NC_005957:2756000:277351027735102774043534Bacillus thuringiensis serovar konkukian str. 97-27, completeacetyltransferase, GNAT family1e-0755.8
NC_014335:2718000:273672827367282737261534Bacillus cereus biovar anthracis str. CI chromosome, completeacetyltransferase, GNAT family1e-0755.8
NC_014364:4416467:442826344282634428829567Spirochaeta smaragdinae DSM 11293 chromosome, complete genomeGCN5-related N-acetyltransferase2e-0755.5
NC_007963:3225306:323117732311773231755579Chromohalobacter salexigens DSM 3043, complete genomeGCN5-related N-acetyltransferase2e-0755.5
NC_013411:1168049:118481611848161185403588Geobacillus sp. Y412MC61, complete genomeGCN5-related N-acetyltransferase2e-0755.5
NC_014915:308056:324823324823325410588Geobacillus sp. Y412MC52 chromosome, complete genomeGCN5-related N-acetyltransferase2e-0755.5
NC_014923:1249267:126575012657501266280531Mesorhizobium ciceri biovar biserrulae WSM1271 chromosome, completeGCN5-related N-acetyltransferase2e-0755.5
NC_000868:378130:390348390348390773426Pyrococcus abyssi GE5, complete genomeacetyl transferase2e-0755.5
NC_014364:394899:427961427961428539579Spirochaeta smaragdinae DSM 11293 chromosome, complete genomeGCN5-related N-acetyltransferase2e-0755.1
NC_016629:1111619:112092811209281121467540Desulfovibrio africanus str. Walvis Bay chromosome, completeN-acetyltransferase GCN52e-0755.1
NC_003888:3111998:313010531301053130731627Streptomyces coelicolor A3(2), complete genomeacetyltransferase3e-0754.7
NC_008593:2457594:249248524924852493423939Clostridium novyi NT, complete genomeprobable ribosomal-protein (S5)-alanine N-acetyltransferase3e-0754.7
NC_013456:1843000:186192618619261862471546Vibrio sp. Ex25 chromosome 1, complete genomeGCN5-related N-acetyltransferase3e-0754.7
NC_013406:5066769:510451951045195105067549Paenibacillus sp. Y412MC10 chromosome, complete genomeGCN5-like N-acetyltransferase3e-0754.7
NC_010516:3545017:354782935478293548362534Clostridium botulinum B1 str. Okra, complete genomeacetyltransferase, GNAT family3e-0754.7
NC_019908:852230:869161869161869658498Brachyspira pilosicoli P43/6/78 chromosome, complete genomeribosomal-protein-alanine acetyltransferase3e-0754.3
NC_021182:2360500:237670623767062377263558Clostridium pasteurianum BC1, complete genomeacetyltransferase, ribosomal protein N-acetylase4e-0754.3
NC_012563:36000:415364153642480945Clostridium botulinum A2 str. Kyoto, complete genomeacetyltransferase, GNAT family7e-0753.5
NC_009495:38000:471224712248066945Clostridium botulinum A str. ATCC 3502 chromosome, complete genomeGNAT family acetyltransferase7e-0753.5
NC_009697:38000:471374713748081945Clostridium botulinum A str. ATCC 19397 chromosome, completeacetyltransferase7e-0753.5
NC_009698:38000:471374713748081945Clostridium botulinum A str. Hall chromosome, complete genomeacetyltransferase7e-0753.5
NC_009699:33452:424794247943423945Clostridium botulinum F str. Langeland chromosome, complete genomeacetyltransferase7e-0753.5
NC_017297:33519:425474254743491945Clostridium botulinum F str. 230613 chromosome, complete genomeGNAT family acetyltransferase7e-0753.5
NC_010516:42475:472134721348157945Clostridium botulinum B1 str. Okra, complete genomeacetyltransferase, GNAT family6e-0753.5
NC_014150:233194:251673251673252173501Brachyspira murdochii DSM 12563 chromosome, complete genomeGCN5-related N-acetyltransferase8e-0753.1
NC_014479:2038348:204952920495292050041513Bacillus subtilis subsp. spizizenii str. W23 chromosome, completeputative N-acetyltransferase9e-0753.1
NC_013895:117429:134107134107134790684Clostridiales genomosp. BVAB3 str. UPII9-5 chromosome, completeacetyltransferase, GNAT family1e-0652.4
NC_016935:4233223:427096342709634271526564Paenibacillus mucilaginosus 3016 chromosome, complete genomehypothetical protein1e-0652.4
NC_014734:353159:360803360803361345543Paludibacter propionicigenes WB4 chromosome, complete genomegcn5-related N-acetyltransferase2e-0652
NC_013315:1230214:124969312496931250139447Clostridium difficile CD196 chromosome, complete genomeacetyltransferase2e-0652
NC_013316:1225797:124731012473101247756447Clostridium difficile R20291, complete genomeputative acetyltransferase2e-0652
NC_013929:6526745:654876765487676549378612Streptomyces scabiei 87.22 chromosome, complete genomeacetyltransferase2e-0651.6
NC_009009:1792317:181013718101371810700564Streptococcus sanguinis SK36, complete genomeAcetyltransferase (N-acetylase of ribosomal proteins), putative2e-0651.6
NC_012658:35500:411124111242056945Clostridium botulinum Ba4 str. 657 chromosome, complete genomeGNAT family acetyltransferase2e-0651.6
NC_006510:2910000:291004129100412910595555Geobacillus kaustophilus HTA426, complete genomehypothetical protein3e-0651.2
NC_015690:4469775:451632945163294516892564Paenibacillus mucilaginosus KNP414 chromosome, complete genomehypothetical protein3e-0651.2
NC_000964:1873398:188237418823741882886513Bacillus subtilis subsp. subtilis str. 168, complete genomehypothetical protein4e-0650.8
NC_013406:5066769:508010550801055080683579Paenibacillus sp. Y412MC10 chromosome, complete genomeGCN5-like N-acetyltransferase4e-0650.8
NC_007516:2277910:231308523130852313660576Synechococcus sp. CC9605, complete genomeacetyltransferase-like7e-0650.1
NC_015496:3256372:326200432620043262606603Krokinobacter diaphorus 4H-3-7-5 chromosome, complete genomeGCN5-related N-acetyltransferase6e-0650.1
NC_017243:1499757:150416315041631504663501Brachyspira intermedia PWS/A chromosome, complete genomeacetyltransferase, GT family9e-0649.7
NC_013421:3279499:329682332968233297341519Pectobacterium wasabiae WPP163, complete genomepseudaminic acid biosynthesis N-acetyl transferase9e-0649.7
NC_017195:1852935:186411018641101864622513Bacillus subtilis subsp. subtilis str. RO-NN-1 chromosome, completeacetyltransferase, gnat family1e-0549.7