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Query: NC_010674:1:15223 Clostridium botulinum B str. Eklund 17B, complete genome

Start: 15223, End: 15735, Length: 513

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum B str. Eklund 17B is a nonproteolytic botulism neurotoxin B strain. This strain was isolated from marine sediments taken off the coast of Washington, USA and was not associated with botulism. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010723:1:151751517515687513Clostridium botulinum E3 str. Alaska E43, complete genome3H domain protein7e-85312
NC_020291:1:152081520815729522Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genome3H domain-containing protein2e-67254
NC_015687:1:152851528515800516Clostridium acetobutylicum DSM 1731 chromosome, complete genomehypothetical protein1e-42172
NC_003030:1:152851528515800516Clostridium acetobutylicum ATCC 824, complete genomeUncharacterized conserved protein, ortholog of YRXA B.subtilis1e-42172
NC_010516:1:149391493915460522Clostridium botulinum B1 str. Okra, complete genomeputative transcriptional regulator2e-41168
NC_012563:1:150921509215613522Clostridium botulinum A2 str. Kyoto, complete genometranscriptional regulator, biotin repressor family4e-41167
NC_009495:1:148951489515416522Clostridium botulinum A str. ATCC 3502 chromosome, complete genometranscriptional regulator4e-41167
NC_009697:1:149101491015431522Clostridium botulinum A str. ATCC 19397 chromosome, completetranscriptional regulator4e-41167
NC_009698:1:149101491015431522Clostridium botulinum A str. Hall chromosome, complete genometranscriptional regulator4e-41167
NC_009699:1:148201482015341522Clostridium botulinum F str. Langeland chromosome, complete genometranscriptional regulator3e-41167
NC_017297:1:148861488615407522Clostridium botulinum F str. 230613 chromosome, complete genomeputative transcriptional regulator3e-41167
NC_010520:1:148891488915410522Clostridium botulinum A3 str. Loch Maree, complete genomeputative transcriptional regulator6e-41166
NC_012658:1:150301503015551522Clostridium botulinum Ba4 str. 657 chromosome, complete genometranscriptional regulator, biotin repressor family6e-41166
NC_004557:32094:371113711137623513Clostridium tetani E88, complete genometranscriptional regulator2e-39161
NC_008593:2527064:253216425321642532676513Clostridium novyi NT, complete genome3H domain protein4e-39160
NC_014328:1:152221522215737516Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeputative transcriptional regulator3e-39160
NC_009706:1:153941539415909516Clostridium kluyveri DSM 555 chromosome, complete genometranscriptional regulator8e-38155
NC_011837:1:153821538215909528Clostridium kluyveri NBRC 12016, complete genomehypothetical protein9e-38155
NC_014393:1:158281582816331504Clostridium cellulovorans 743B chromosome, complete genome3H domain-containing protein3e-36150
NC_015425:2752482:275756927575692758096528Clostridium botulinum BKT015925 chromosome, complete genome3H domain-containing protein5e-36150
NC_015555:693461:699164699164699676513Thermoanaerobacterium xylanolyticum LX-11 chromosome, complete3H domain-containing protein7e-36149
NC_014410:2149886:216496321649632165475513Thermoanaerobacterium thermosaccharolyticum DSM 571 chromosome,3H domain protein4e-34143
NC_009922:1:163491634916867519Alkaliphilus oremlandii OhILAs, complete genome3H domain protein7e-34143
NC_019970:2190695:220877322087732209285513Thermoanaerobacterium thermosaccharolyticum M0795, complete genomeputative small molecule binding protein (contains 3H domain)2e-32138
NC_010718:2551000:258504825850482585572525Natranaerobius thermophilus JW/NM-WN-LF, complete genome3H domain protein3e-32137
NC_009089:1:160731607316600528Clostridium difficile 630, complete genomeputative small-molecule-binding protein3e-31134
NC_014377:1985714:200742120074212007930510Thermosediminibacter oceani DSM 16646 chromosome, complete genome3H domain protein4e-31134
NC_017200:4240500:425313642531364253678543Bacillus thuringiensis serovar finitimus YBT-020 chromosome,putative transcriptional regulator1e-29128
NC_013316:1:158531585316362510Clostridium difficile R20291, complete genomeputative small-molecule-binding protein1e-28125
NC_015737:1337605:133851213385121339066555Clostridium sp. SY8519, complete genomehypothetical protein2e-25115
NC_015975:558523:582385582385582939555Lactobacillus ruminis ATCC 27782 chromosome, complete genomeputative transcriptional regulator1e-22105