Pre_GI: BLASTP Hits

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Query: NC_010674:1986000:1997033 Clostridium botulinum B str. Eklund 17B, complete genome

Start: 1997033, End: 1997752, Length: 720

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum B str. Eklund 17B is a nonproteolytic botulism neurotoxin B strain. This strain was isolated from marine sediments taken off the coast of Washington, USA and was not associated with botulism. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_000964:1330000:133822213382221338929708Bacillus subtilis subsp. subtilis str. 168, complete genomehypothetical protein3e-0755.5
NC_016077:1388775:140147214014721402158687Acidaminococcus intestini RyC-MR95 chromosome, complete genomehypothetical protein6e-0651.2
NC_020291:795500:837645837645838124480Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomehypothetical protein6e-0754.7
NC_020244:1335531:134209013420901342749660Bacillus subtilis XF-1, complete genomehypothetical protein5e-0755.1
UCMB5137:861734:875509875509876168660Bacillus atrophaeus UCMB-5137hypothetical protein2e-0652.8
NC_017297:2531750:253784125378412538518678Clostridium botulinum F str. 230613 chromosome, complete genomelysM domain protein7e-0754.3
NC_017195:1308730:131587613158761316487612Bacillus subtilis subsp. subtilis str. RO-NN-1 chromosome, completeLysM domain protein2e-0652.8
NC_016047:261304:266639266639267298660Bacillus subtilis subsp. spizizenii TU-B-10 chromosome, completeLysM domain-containing protein2e-0652.4
NC_020291:795500:851136851136851813678Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomeLysM domain-containing protein9e-1167
NC_010723:915697:926873926873927535663Clostridium botulinum E3 str. Alaska E43, complete genomepeptidoglycan-binding LysM2e-0859.3
NC_014976:3546884:355283535528353553494660Bacillus subtilis BSn5 chromosome, complete genomeputative PBSX prophage murein binding protein3e-0755.5