Pre_GI: BLASTP Hits

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Query: NC_010674:1124431:1134131 Clostridium botulinum B str. Eklund 17B, complete genome

Start: 1134131, End: 1135132, Length: 1002

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum B str. Eklund 17B is a nonproteolytic botulism neurotoxin B strain. This strain was isolated from marine sediments taken off the coast of Washington, USA and was not associated with botulism. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010723:1084000:1096029109602910970301002Clostridium botulinum E3 str. Alaska E43, complete genomephosphoribosylformylglycinamidine cyclo-ligase0665
NC_020291:1266885:1276364127636412773651002Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomephosphoribosylformylglycinamidine cyclo-ligase PurM1e-179629
NC_009617:1255762:1267604126760412686051002Clostridium beijerinckii NCIMB 8052 chromosome, complete genomephosphoribosylaminoimidazole synthetase3e-176617
NC_008262:784878:7949127949127959131002Clostridium perfringens SM101, complete genomephosphoribosylformylglycinamidine cyclo-ligase3e-149528
NC_003366:842000:8521048521048531051002Clostridium perfringens str. 13, complete genomephosphoribosylaminoimidazole synthetase3e-144511
NC_003030:1510000:153704315370431538041999Clostridium acetobutylicum ATCC 824, complete genomephosphoribosylaminoimidazole synthetase9e-139493
NC_009495:3051223:3059191305919130601951005Clostridium botulinum A str. ATCC 3502 chromosome, complete genomephosphoribosylaminoimidazole synthetase4e-138491
NC_012563:3288124:329622032962203297215996Clostridium botulinum A2 str. Kyoto, complete genomephosphoribosylformylglycinamidine cyclo-ligase3e-138491
NC_009697:2984173:299214129921412993136996Clostridium botulinum A str. ATCC 19397 chromosome, completephosphoribosylaminoimidazole synthetase3e-138491
NC_009698:2921097:292906529290652930060996Clostridium botulinum A str. Hall chromosome, complete genomephosphoribosylaminoimidazole synthetase3e-138491
NC_012658:3126108:313392831339283134923996Clostridium botulinum Ba4 str. 657 chromosome, complete genomephosphoribosylaminoimidazole synthetase6e-138490
NC_010520:3120500:312959231295923130587996Clostridium botulinum A3 str. Loch Maree, complete genomephosphoribosylformylglycinamidine cyclo-ligase8e-137486
NC_008593:1631438:164140316414031642398996Clostridium novyi NT, complete genomephosphoribosylformylglycinamidine cyclo-ligase2e-133475
NC_015425:1867620:188063218806321881627996Clostridium botulinum BKT015925 chromosome, complete genomephosphoribosylformylglycinamidine cyclo-ligase6e-132470
NC_014328:938393:945063945063946058996Clostridium ljungdahlii ATCC 49587 chromosome, complete genomephosphoribosylformylglycinamidine cyclo-ligase5e-131467
NC_021182:2059143:206957420695742070569996Clostridium pasteurianum BC1, complete genomephosphoribosylaminoimidazole synthetase2e-128458
NC_004557:2078000:208966720896672090662996Clostridium tetani E88, complete genomephosphoribosylaminoimidazole synthetase2e-125448
NC_014633:265086:275691275691276689999Ilyobacter polytropus DSM 2926 plasmid pILYOP01, complete sequencephosphoribosylformylglycinamidine cyclo-ligase6e-112404
NC_012225:1657248:1664529166452916655421014Brachyspira hyodysenteriae WA1, complete genomephosphoribosylaminoimidazole synthetase2e-111402
NC_017243:424132:4384284384284394411014Brachyspira intermedia PWS/A chromosome, complete genomephosphoribosylaminoimidazole synthetase3e-111401
NC_015732:2710913:2715789271578927169881200Spirochaeta caldaria DSM 7334 chromosome, complete genomephosphoribosylformylglycinamidine cyclo-ligase3e-104378
NC_020134:2295092:2302185230218523032761092Clostridium stercorarium subsp. stercorarium DSM 8532, completephosphoribosylformylglycinamidine cyclo-ligase PurM2e-102372
NC_011567:238249:2602652602652613021038Anoxybacillus flavithermus WK1, complete genomePhosphoribosylaminoimidazole synthetase3e-100365
NC_009633:947695:9591409591409601831044Alkaliphilus metalliredigens QYMF chromosome, complete genomephosphoribosylaminoimidazole synthetase7e-98357
NC_010001:4250828:4271626427162642726511026Clostridium phytofermentans ISDg, complete genomephosphoribosylformylglycinamidine cyclo-ligase6e-97354
NC_015519:1113095:1123191112319111242251035Tepidanaerobacter sp. Re1 chromosome, complete genomephosphoribosylformylglycinamidine cyclo-ligase3e-96352
NC_007517:2055305:2056726205672620577721047Geobacter metallireducens GS-15, complete genomephosphoribosylaminoimidazole synthetase1e-94347
NC_011979:3045952:3047466304746630485121047Geobacter sp. FRC-32, complete genomephosphoribosylformylglycinamidine cyclo-ligase1e-92340
NC_010814:2217153:2245423224542322464721050Geobacter lovleyi SZ, complete genomephosphoribosylformylglycinamidine cyclo-ligase9e-93340
NC_009053:1257302:1266330126633012673671038Actinobacillus pleuropneumoniae L20, complete genomephosphoribosylformylglycinamidine cyclo-ligase2e-91335
NC_009483:2489000:2509054250905425101001047Geobacter uraniireducens Rf4 chromosome, complete genomephosphoribosylaminoimidazole synthetase3e-91335
NC_002976:638799:6510776510776521081032Staphylococcus epidermidis RP62A, complete genomephosphoribosylaminoimidazole synthetase6e-91334
NC_004461:746284:7585617585617595921032Staphylococcus epidermidis ATCC 12228, complete genomephosphoribosylaminoimidazole synthetase6e-91334
NC_006814:1538175:1546668154666815477051038Lactobacillus acidophilus NCFM, complete genomephosphoribosylaminoimidazole synthetase7e-91333
NC_007168:1923723:1931941193194119329721032Staphylococcus haemolyticus JCSC1435, complete genomephosphoribosylaminoimidazole synthetase2e-89328
NC_007951:570500:5918285918285928951068Burkholderia xenovorans LB400 chromosome 1, complete sequencePhosphoribosylformylglycinamidine cyclo-ligase3e-89328
NC_011999:728353:7467387467387477601023Macrococcus caseolyticus JCSC5402, complete genomephosphoribosylformylglycinamidine cyclo-ligase homolog5e-88324
NC_006905:2630000:2630368263036826314051038Salmonella enterica subsp. enterica serovar Choleraesuis strphosphoribosylaminoimidazole synthetase9e-88323
NC_004193:783958:7952317952317962501020Oceanobacillus iheyensis HTE831, complete genomephosphoribosylaminoimidazole synthetase9e-88323
NC_017208:256163:3157213157213167611041Bacillus thuringiensis serovar chinensis CT-43 chromosome, completephosphoribosylaminoimidazole synthetase1e-87323
NC_020063:1194000:1215725121572512167621038Enterobacteriaceae bacterium strain FGI 57, complete genomephosphoribosylformylglycinamidine cyclo-ligase2e-87322
NC_009443:29349:3665236652376891038Streptococcus suis 98HAH33, complete genomephosphoribosylaminoimidazole synthetase1e-86320
NC_012925:29353:3667136671376931023Streptococcus suis P1/7, complete genomephosphoribosylaminoimidazole synthetase9e-87320
NC_012924:29353:3667136671376931023Streptococcus suis SC84, complete genomephosphoribosylaminoimidazole synthetase9e-87320
NC_012926:30351:3666936669376911023Streptococcus suis BM407 chromosome, complete genomephosphoribosylaminoimidazole synthetase9e-87320
NC_009253:2577316:2587839258783925888911053Desulfotomaculum reducens MI-1 chromosome, complete genomephosphoribosylaminoimidazole synthetase8e-87320
NC_014614:356746:3829183829183839761059Clostridium sticklandii, complete genomephosphoribosylaminoimidazole synthetase6e-87320
NC_014498:99015:1043121043121053341023Streptococcus pneumoniae 670-6B chromosome, complete genomephosphoribosylformylglycinamidine cyclo-ligase1e-86319
NC_010380:124655:1299521299521309741023Streptococcus pneumoniae Hungary19A-6, complete genomephosphoribosylformylglycinamidine cyclo-ligase1e-86319
NC_018704:433402:4438144438144448421029Amphibacillus xylanus NBRC 15112, complete genomephosphoribosylformylglycinamidine cyclo-ligase4e-86318
NC_005125:760721:7643547643547653671014Gloeobacter violaceus PCC 7421, complete genomephosphoribosylaminoimidazole synthetase7e-86317
NC_015677:2939301:2961805296180529628391035Ramlibacter tataouinensis TTB310 chromosome, complete genomephosphoribosylformylglycinamidine cyclo-ligase6e-86317
NC_020164:1784223:1790470179047017914981029Staphylococcus warneri SG1, complete genomephosphoribosylaminoimidazole synthetase1e-85316
NC_008022:35983:4228242282433041023Streptococcus pyogenes MGAS10270, complete genomePhosphoribosylformylglycinamidine cyclo-ligase2e-85316
NC_002516:1031386:1032763103276310338241062Pseudomonas aeruginosa PAO1, complete genomephosphoribosylaminoimidazole synthetase4e-85315
NC_008024:35948:4217442174431961023Streptococcus pyogenes MGAS10750, complete genomePhosphoribosylformylglycinamidine cyclo-ligase4e-85315
NC_003485:35971:4219742197432191023Streptococcus pyogenes MGAS8232, complete genomephosphoribosylaminoimidazole synthetase4e-85315
NC_007296:35661:4188741887429091023Streptococcus pyogenes MGAS6180, complete genomephosphoribosylaminoimidazole synthetase3e-85315
NC_008023:35663:4188941889429111023Streptococcus pyogenes MGAS2096, complete genomePhosphoribosylformylglycinamidine cyclo-ligase4e-85314
NC_014829:443500:4556024556024566391038Bacillus cellulosilyticus DSM 2522 chromosome, complete genomephosphoribosylformylglycinamidine cyclo-ligase8e-85313
NC_010556:462500:4826614826614836951035Exiguobacterium sibiricum 255-15, complete genomephosphoribosylformylglycinamidine cyclo-ligase8e-85313
NC_017179:281069:2879072879072889831077Clostridium difficile BI1, complete genomephosphoribosylformylglycinamidine cyclo-ligase2e-84312
NC_007759:1666967:1670907167090716719501044Syntrophus aciditrophicus SB, complete genomephosphoribosylformylglycinamidine cyclo-ligase6e-84311
NC_013928:9494:3822938229393891161Streptococcus mutans NN2025, complete genomephosphoribosylformylglycinamide cyclo-ligase (AIRS); phosphoribosyl aminoimidazole synthetase3e-84311
NC_020418:2718500:2737662273766227387021041Morganella morganii subsp. morganii KT, complete genomePhosphoribosylformylglycinamidine cyclo-ligase2e-83309
NC_014169:703889:7094217094217104581038Bifidobacterium longum subsp. longum JDM301 chromosome, completephosphoribosylformylglycinamidine cyclo-ligase3e-83308
NC_008021:35661:4188741887429361050Streptococcus pyogenes MGAS9429, complete genomephosphoribosylformylglycinamidine cyclo-ligase1e-82306
NC_013939:148706:1711781711781722241047Deferribacter desulfuricans SSM1, complete genomephosphoribosylformylglycinamidine cyclo-ligase6e-82304
NC_009943:305854:3365653365653376051041Candidatus Desulfococcus oleovorans Hxd3, complete genomephosphoribosylformylglycinamidine cyclo-ligase7e-82304
NC_015391:2488450:2499495249949525005471053Carnobacterium sp. 17-4 chromosome, complete genomephosphoribosylformylglycinamidine cyclo-ligase9e-82303
NC_010718:464405:4811264811264822081083Natranaerobius thermophilus JW/NM-WN-LF, complete genomephosphoribosylformylglycinamidine cyclo-ligase2e-77289
NC_007516:413159:4131594131594142651107Synechococcus sp. CC9605, complete genomephosphoribosylaminoimidazole synthetase4e-77288
NC_009513:169146:1691461691461701831038Lactobacillus reuteri F275, complete genomephosphoribosylaminoimidazole synthetase7e-76284
NC_005070:1898612:1927391192739119284221032Synechococcus sp. WH 8102, complete genomephosphoribosylaminoimidazole synthetase2e-75283
NC_007493:546000:5607375607375617831047Rhodobacter sphaeroides 2.4.1 chromosome 1, complete sequencephosphoribosylaminoimidazole synthetase4e-75281
NC_015672:101878:1098821098821109161035Flexistipes sinusarabici DSM 4947 chromosome, complete genomephosphoribosylformylglycinamidine cyclo-ligase5e-75281
NC_009714:74500:914549145492437984Campylobacter hominis ATCC BAA-381, complete genomephosphoribosylaminoimidazole synthetase8e-75280
NC_009482:1761529:1791088179108817921221035Synechococcus sp. RCC307 chromosome, complete genomephosphoribosylaminoimidazole synthetase9e-74277
NC_011297:1224749:1250904125090412519891086Dictyoglomus thermophilum H-6-12, complete genomephosphoribosylformylglycinamidine cyclo-ligase2e-72273
NC_014774:1210004:1053810538116111074Candidatus Liberibacter solanacearum CLso-ZC1 chromosome, completephosphoribosylaminoimidazole synthetase1e-72273
NC_020453:4696000:4717360471736047184331074Agromonas oligotrophica S58 DNA, complete genomePpx/GppA phosphatase3e-72272
NC_011661:1411383:1431173143117314322581086Dictyoglomus turgidum DSM 6724, complete genomephosphoribosylformylglycinamidine cyclo-ligase9e-70264
NC_015389:2030154:2054654205465420557691116Coriobacterium glomerans PW2 chromosome, complete genomephosphoribosylformylglycinamidine cyclo-ligase9e-65247
NC_001263:1378605:1398366139836613994301065Deinococcus radiodurans R1 chromosome 1, complete sequencephosphoribosylaminoimidazole synthetase1e-64247
NC_014408:1455851:1455851145585114568671017Methanothermobacter marburgensis str. Marburg chromosome, completephosphoribosylformylglycinamidine cyclo-ligase7e-55214
NC_015636:379000:3801293801293811811053Methanothermococcus okinawensis IH1 chromosome, complete genomephosphoribosylformylglycinamidine cyclo-ligase1e-54213
NC_013156:431795:4534174534174544691053Methanocaldococcus fervens AG86, complete genomephosphoribosylformylglycinamidine cyclo-ligase3e-54212
NC_013407:333387:3379483379483390031056Methanocaldococcus vulcanius M7, complete genomephosphoribosylformylglycinamidine cyclo-ligase4e-53208
NC_006087:2326143:2348963234896323500811119Leifsonia xyli subsp. xyli str. CTCB07, complete genomephosphoribosylaminoimidazole synthetase9e-51201
NC_002754:537792:550574550574551545972Sulfolobus solfataricus P2, complete genomephosphoribosylaminoimidazole synthetase3e-49196
NC_009440:1908864:191917519191751920146972Metallosphaera sedula DSM 5348 chromosome, complete genomephosphoribosylaminoimidazole synthetase6e-49194
NC_015518:997707:101011010101101011078969Acidianus hospitalis W1 chromosome, complete genomephosphoribosylformylglycinamidine cyclo-ligase3e-47189
NC_007181:1364522:137603613760361376998963Sulfolobus acidocaldarius DSM 639, complete genomephosphoribosylaminoimidazole synthetase4e-45182
NC_007955:2074844:2079854207985420808551002Methanococcoides burtonii DSM 6242, complete genomephosphoribosylformylglycinamidine cyclo-ligase3e-45182
NC_012589:1482075:148965514896551490623969Sulfolobus islandicus L.S.2.15, complete genomephosphoribosylformylglycinamidine cyclo-ligase3e-44179
NC_012588:1394103:140168314016831402651969Sulfolobus islandicus M.14.25 chromosome, complete genomephosphoribosylaminoimidazole synthetase3e-44179
NC_013769:1478546:148612614861261487094969Sulfolobus islandicus L.D.8.5 chromosome, complete genomephosphoribosylformylglycinamidine cyclo-ligase3e-44179
NC_012632:1518520:152610015261001527068969Sulfolobus islandicus M.16.27 chromosome, complete genomephosphoribosylaminoimidazole synthetase2e-44179
NC_012726:1382095:138967513896751390643969Sulfolobus islandicus M.16.4 chromosome, complete genomephosphoribosylaminoimidazole synthetase2e-44179
NC_012622:1371448:137902813790281379996969Sulfolobus islandicus Y.G.57.14 chromosome, complete genomephosphoribosylaminoimidazole synthetase2e-44179
NC_012623:1167289:117809611780961179064969Sulfolobus islandicus Y.N.15.51 chromosome, complete genomephosphoribosylaminoimidazole synthetase2e-44179
NC_017275:1436875:144445614444561445424969Sulfolobus islandicus HVE10/4 chromosome, complete genomephosphoribosylformylglycinamidine cyclo-ligase2e-44179
NC_017276:1285824:129340512934051294373969Sulfolobus islandicus REY15A chromosome, complete genomephosphoribosylformylglycinamidine cyclo-ligase2e-44179
NC_003106:1484768:149548614954861496445960Sulfolobus tokodaii str. 7, complete genomephosphoribosylaminoimidazole synthetase9e-44177
NC_015435:251958:266467266467267438972Metallosphaera cuprina Ar-4 chromosome, complete genomephosphoribosylaminoimidazole synthetase5e-41168
NC_014471:217279:2312502312502322751026Ignisphaera aggregans DSM 17230 chromosome, complete genomephosphoribosylformylglycinamidine cyclo-ligase8e-38157
NC_011653:748844:750937750937751842906Thermosipho africanus TCF52B, complete genomephosphoribosylformylglycinamidine cyclo-ligase2e-37156
NC_014537:542515:5595395595395605401002Vulcanisaeta distributa DSM 14429 chromosome, complete genomephosphoribosylformylglycinamidine cyclo-ligase2e-34146
NC_015151:1872280:1904060190406019050611002Vulcanisaeta moutnovskia 768-28 chromosome, complete genomephosphoribosylformylglycinamidine cyclo-ligase3e-33142
NC_017095:2058921:206302320630232064015993Fervidobacterium pennivorans DSM 9078 chromosome, complete genomephosphoribosylaminoimidazole (AIR) synthetase4e-32139
NC_016645:797000:818520818520819446927Pyrobaculum sp. 1860 chromosome, complete genomephosphoribosylaminoimidazole synthetase9e-25114
NC_013156:573037:5884705884705894771008Methanocaldococcus fervens AG86, complete genomehydrogenase expression/formation protein HypE1e-0964.3
NC_013887:1462918:1476310147631014773171008Methanocaldococcus sp. FS406-22 chromosome, complete genomehydrogenase expression/formation protein HypE2e-0860.1
NC_000909:597692:6020816020816030881008Methanocaldococcus jannaschii DSM 2661, complete genomehydrogenase expression/formation protein (hypE)3e-0859.7
NC_015474:723553:7733787733787754922115Pyrococcus sp. NA2 chromosome, complete genomephosphoribosylformylglycinamidine synthase II5e-0652