Pre_GI: BLASTP Hits

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Query: NC_010674:1124431:1125509 Clostridium botulinum B str. Eklund 17B, complete genome

Start: 1125509, End: 1126765, Length: 1257

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum B str. Eklund 17B is a nonproteolytic botulism neurotoxin B strain. This strain was isolated from marine sediments taken off the coast of Washington, USA and was not associated with botulism. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010723:1084000:1086625108662510878811257Clostridium botulinum E3 str. Alaska E43, complete genomevoltage gated chloride channel family0799
NC_008262:654000:6569946569946583071314Clostridium perfringens SM101, complete genomeVoltage gated chloride channel family3e-76285
NC_008261:676000:6791236791236804361314Clostridium perfringens ATCC 13124, complete genomevoltage-gated chloride channel family protein1e-75283
NC_003366:728859:7317577317577330701314Clostridium perfringens str. 13, complete genomehypothetical protein6e-75281
NC_013732:136673:1412531412531426111359Spirosoma linguale DSM 74 plasmid pSLIN02, complete sequenceCl- channel voltage-gated family protein4e-74278
NC_016609:1774259:1775725177572517770801356Niastella koreensis GR20-10 chromosome, complete genomeCl- channel voltage-gated family protein1e-69263
NC_010002:1879220:1925073192507319263681296Delftia acidovorans SPH-1, complete genomeChloride channel core5e-69261
NC_012660:2045398:2080357208035720817031347Pseudomonas fluorescens SBW25 chromosome, complete genomeputative chloride transporter-like membrane protein4e-67255
NC_007005:1636875:1673655167365516750011347Pseudomonas syringae pv. syringae B728a, complete genomeCl- channel, voltage gated1e-66253
NC_004578:5192110:5214210521421052155681359Pseudomonas syringae pv. tomato str. DC3000, complete genomevoltage-gated chloride channel family protein1e-66253
NC_005085:2609934:2611860261186026131761317Chromobacterium violaceum ATCC 12472, complete genomeprobable chloride channel protein EriC2e-65249
NC_015510:1012195:1028814102881410301211308Haliscomenobacter hydrossis DSM 1100 chromosome, complete genomeCl- channel voltage-gated family protein5e-62238
NC_020126:117799:1370821370821383951314Myxococcus stipitatus DSM 14675, complete genomeCl- channel voltage-gated family protein4e-54212
NC_013928:797714:8059268059268071461221Streptococcus mutans NN2025, complete genomepermease4e-40166
NC_020541:2487427:2487427248742724888151389Rhodanobacter sp. 2APBS1, complete genomechloride channel protein EriC2e-38160
NC_013928:797714:8072328072328084521221Streptococcus mutans NN2025, complete genomepermease2e-36153
NC_015738:1858455:1879177187917718804661290Eggerthella sp. YY7918, complete genomechloride channel protein EriC8e-36151
NC_012926:1496510:1517504151750415187181215Streptococcus suis BM407 chromosome, complete genomevoltage gated chloride channel protein2e-34147
NC_012924:1446190:1467165146716514683791215Streptococcus suis SC84, complete genomevoltage gated chloride channel protein2e-34147
NC_009443:1445936:1466904146690414681181215Streptococcus suis 98HAH33, complete genomehypothetical protein2e-34147
NC_009442:1446508:1467483146748314686971215Streptococcus suis 05ZYH33 chromosome, complete genomehypothetical protein2e-34147
NC_012925:1357783:1378756137875613799701215Streptococcus suis P1/7, complete genomevoltage gated chloride channel protein2e-34147
NC_011835:813345:8340788340788356491572Bifidobacterium animalis subsp. lactis AD011 chromosome, completevoltage-gated chloride channel family protein8e-34145
NC_012814:1682500:1703308170330817049661659Bifidobacterium animalis subsp. lactis Bl-04, complete genomevoltage gated chloride channel family protein2e-33144
NC_012815:1682872:1703026170302617046841659Bifidobacterium animalis subsp. lactis DSM 10140, complete genomevoltage gated chloride channel family protein2e-33144
NC_017216:1682219:1702954170295417046121659Bifidobacterium animalis subsp. lactis BLC1, complete genomechloride channel protein EriC2e-33144
NC_017217:1688441:1708595170859517102531659Bifidobacterium animalis subsp. lactis V9 chromosome, completevoltage gated chloride channel family protein2e-33144
NC_017215:1687161:1707896170789617096291734Bifidobacterium animalis subsp. lactis CNCM I-2494 chromosome,Chloride channel protein4e-33142
NC_017214:379728:4004464004464021791734Bifidobacterium animalis subsp. lactis BB-12 chromosome, completeChloride channel protein4e-33142
NC_013410:2586500:2608776260877626101821407Fibrobacter succinogenes subsp. succinogenes S85 chromosome,Cl- channel voltage-gated family protein1e-29130
NC_015320:1399589:1417496141749614192651770Archaeoglobus veneficus SNP6 chromosome, complete genomeCl- channel voltage-gated family protein7e-22105
NC_014122:393856:3987973987973999571161Methanocaldococcus infernus ME chromosome, complete genomeCl- channel voltage-gated family protein2e-1894
NC_012483:483425:5090275090275107451719Acidobacterium capsulatum ATCC 51196, complete genomechloride transporter, ClC family5e-1685.9
NC_015151:1427965:1441107144110714424951389Vulcanisaeta moutnovskia 768-28 chromosome, complete genomechloride channel core4e-1583.2
NC_011126:555483:5620315620315634581428Hydrogenobaculum sp. Y04AAS1, complete genomeChloride channel core6e-1582.4
NC_011027:817311:8350488350488369371890Chlorobaculum parvum NCIB 8327, complete genomeChloride channel core7e-1582
NC_014537:603564:6185926185926199591368Vulcanisaeta distributa DSM 14429 chromosome, complete genomeCl- channel voltage-gated family protein1e-1481.3
NC_007514:1840971:1863568186356818654631896Chlorobium chlorochromatii CaD3, complete genomechloride channel, putative2e-1377.4
NC_008340:480399:4803994803994821261728Alkalilimnicola ehrlichei MLHE-1, complete genomeCl- channel, voltage-gated family protein3e-1376.6
NC_013166:417862:4182924182924200671776Kangiella koreensis DSM 16069, complete genomeChloride channel core7e-1375.5
NC_004663:5099845:5119138511913851209341797Bacteroides thetaiotaomicron VPI-5482, complete genomeputative chloride channel protein1e-1171.6
NC_013205:1123280:1155829115582911575831755Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446,Cl- channel voltage-gated family protein1e-1171.2
NC_015425:2072703:2077160207716020787521593Clostridium botulinum BKT015925 chromosome, complete genomeVoltage gated chloride channel family protein3e-1170.1
NC_002689:78297:9714297142989201779Thermoplasma volcanium GSS1, complete genomeChloride channel protein1e-1067.8
NC_017168:3192817:3208417320841732097091293Yersinia pestis A1122 chromosome, complete genomeputative voltage-gated ClC-type chloride channel ClcB3e-1066.6
NC_014640:6971000:6989479698947969908461368Achromobacter xylosoxidans A8 chromosome, complete genomevoltage gated chloride channel family protein 36e-1065.9
NC_011894:2184956:2198418219841822002291812Methylobacterium nodulans ORS 2060, complete genomeChloride channel core5e-1065.9
NC_017080:1194199:1194199119419911959471749Phycisphaera mikurensis NBRC 102666, complete genomeputative ClC chloride channel7e-0962.4
NC_014532:2298628:2300945230094523027231779Halomonas elongata DSM 2581, complete genomeK03281 chloride channel protein, CIC family7e-0962
NC_015057:268000:2720462720462737701725Acidobacterium sp. MP5ACTX9 plasmid pACIX901, complete sequenceCl- channel voltage-gated family protein7e-0962
NC_011206:2685499:2715535271553527169591425Acidithiobacillus ferrooxidans ATCC 53993, complete genomeChloride channel core2e-0860.8
NC_011761:2785660:2815696281569628170991404Acidithiobacillus ferrooxidans ATCC 23270 chromosome, completevoltage-gated chloride channel3e-0860.1
NC_008369:82515:9647596475978931419Francisella tularensis subsp. holarctica OSU18, complete genomeCLC family chloride ion channel antiporter1e-0758.2
NC_009257:5615:6084608475021419Francisella tularensis subsp. tularensis WY96-3418 chromosome,chloride channel protein1e-0758.2
NC_015177:3195249:3195249319524931965261278Pedobacter saltans DSM 12145 chromosome, complete genomeCl- channel voltage-gated family protein1e-0757.8
NC_008245:1845525:1864990186499018665191530Francisella tularensis subsp. tularensis FSC 198, complete genomeVoltage-gated ClC-type chloride channel clcA2e-0757.4
NC_009749:77583:9653396533978761344Francisella tularensis subsp. holarctica FTA, complete genomechloride channel protein4e-0756.6
NC_002967:2194829:2209088220908822106741587Treponema denticola ATCC 35405, complete genomevoltage-gated chloride channel1e-0654.7
NC_016937:1850382:1863731186373118665652835Francisella tularensis subsp. tularensis TI0902 chromosome,Thermostable carboxypeptidase 17e-0652.4
NC_014562:2871765:2899212289921229009001689Pantoea vagans C9-1 chromosome, complete genomePutative ClC family transporter9e-0652