Pre_GI: BLASTP Hits

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Query: NC_010660:175200:193116 Shigella boydii CDC 3083-94 plasmid pBS512_211, complete sequence

Start: 193116, End: 193973, Length: 858

Host Lineage: Shigella boydii; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain (strain BS512; serotype 18) was originally isolated from a 12-year-old boy in Arizona, USA by Dr. Nancy Stockbine. It is a member of Group 1 as determined by limited sequence analysis and can invade HeLa cells. Pathogenicity and virulence have been verified during in vitro experimentation, and multiple plasmids are present in this strain. This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. Shigella spp. are extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This species is uncommon except in India, where it was first isolated. Progression to clinical dysentery occurs in most patients infected with this organism.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017319:192482:209331209331210188858Shigella flexneri 2002017 plasmid pSFxv_1, complete sequenceRepA4e-128457
NC_004851:191709:209448209448210305858Shigella flexneri 2a str. 301 plasmid pCP301, complete sequenceRepA, replication protein4e-128457
NC_007608:97092:112308112308113165858Shigella boydii Sb227 plasmid pSB4_227, complete sequenceRepA4e-128457
NC_007607:87000:107005107005107862858Shigella dysenteriae Sd197 plasmid pSD1_197, complete sequenceRepA5e-125447
NC_009787:17344:290512905129908858Escherichia coli E24377A plasmid pETEC_35, complete sequencereplication initiation protein RepA1e-120432
NC_011749:34056:510235102351892870Escherichia coli UMN026 plasmid p1ESCUM, complete sequencereplication protein4e-119427
NC_009378:106193:114854114854115717864Yersinia pestis Pestoides F plasmid MT, complete sequencereplication protein2e-95348
NC_016846:24500:382223822239079858Klebsiella pneumoniae subsp. pneumoniae HS11286 plasmid pKPHS2,replication initiation protein RepA3e-94345
NC_012752:1:11840840Candidatus Hamiltonella defensa 5AT (Acyrthosiphon pisum) plasmidplasmid replication initiator protein6e-1065.1