Pre_GI: BLASTP Hits

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Query: NC_010660:175200:189747 Shigella boydii CDC 3083-94 plasmid pBS512_211, complete sequence

Start: 189747, End: 189959, Length: 213

Host Lineage: Shigella boydii; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain (strain BS512; serotype 18) was originally isolated from a 12-year-old boy in Arizona, USA by Dr. Nancy Stockbine. It is a member of Group 1 as determined by limited sequence analysis and can invade HeLa cells. Pathogenicity and virulence have been verified during in vitro experimentation, and multiple plasmids are present in this strain. This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. Shigella spp. are extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This species is uncommon except in India, where it was first isolated. Progression to clinical dysentery occurs in most patients infected with this organism.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_007608:97092:109716109716109928213Shigella boydii Sb227 plasmid pSB4_227, complete sequencehypothetical protein1e-24111
NC_017319:192482:205472205472205684213Shigella flexneri 2002017 plasmid pSFxv_1, complete sequencehypothetical protein4e-24110
NC_007607:87000:102863102863103075213Shigella dysenteriae Sd197 plasmid pSD1_197, complete sequencehypothetical protein4e-24110
NC_004851:191709:205589205589205801213Shigella flexneri 2a str. 301 plasmid pCP301, complete sequencehypothetical protein4e-24110
NC_011749:34056:542695426954481213Escherichia coli UMN026 plasmid p1ESCUM, complete sequencehypothetical protein1e-1375.5