Pre_GI: BLASTP Hits

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Query: NC_010660:175200:188255 Shigella boydii CDC 3083-94 plasmid pBS512_211, complete sequence

Start: 188255, End: 189001, Length: 747

Host Lineage: Shigella boydii; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain (strain BS512; serotype 18) was originally isolated from a 12-year-old boy in Arizona, USA by Dr. Nancy Stockbine. It is a member of Group 1 as determined by limited sequence analysis and can invade HeLa cells. Pathogenicity and virulence have been verified during in vitro experimentation, and multiple plasmids are present in this strain. This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. Shigella spp. are extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This species is uncommon except in India, where it was first isolated. Progression to clinical dysentery occurs in most patients infected with this organism.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017319:192482:203974203974204726753Shigella flexneri 2002017 plasmid pSFxv_1, complete sequenceF pilin acetylation protein3e-121434
NC_007608:97092:108224108224108970747Shigella boydii Sb227 plasmid pSB4_227, complete sequenceF pilin acetylation protein3e-121434
NC_007607:87000:101371101371102117747Shigella dysenteriae Sd197 plasmid pSD1_197, complete sequenceF pilin acetylation protein8e-121432
NC_004851:191709:204097204097204843747Shigella flexneri 2a str. 301 plasmid pCP301, complete sequenceF pilin acetylation protein2e-120431
NC_007414:56508:903109031091056747Escherichia coli O157:H7 EDL933 plasmid pO157, complete sequenceF pilin acetylase2e-113408
NC_007385:157516:175899175899176646748Shigella sonnei Ss046 plasmid pSS_046, complete sequence2e-73275
NC_016846:24500:459494594946674726Klebsiella pneumoniae subsp. pneumoniae HS11286 plasmid pKPHS2,type-F conjugative transfer system pilin acetylase TraX3e-51201
NC_013716:4306695:433824643382464338584339Citrobacter rodentium ICC168, complete genome9e-49193
NC_009378:106193:111435111435112172738Yersinia pestis Pestoides F plasmid MT, complete sequenceconjugative transfer fimbrial acetylation protein7e-44177
NC_009787:17344:324793247933237759Escherichia coli E24377A plasmid pETEC_35, complete sequencetype-F conjugative transfer system pilin acetylase TraX7e-2097.4
NC_013285:1:152471524715981735Cronobacter turicensis plasmid pCTU3, complete sequencehypothetical protein4e-1788.6
NC_013722:1785692:179032317903231790991669Xanthomonas albilineans, complete genomeputative f pilin acetylation protein8e-0857.4