Pre_GI: BLASTP Hits

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Query: NC_010660:175200:180200 Shigella boydii CDC 3083-94 plasmid pBS512_211, complete sequence

Start: 180200, End: 182245, Length: 2046

Host Lineage: Shigella boydii; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain (strain BS512; serotype 18) was originally isolated from a 12-year-old boy in Arizona, USA by Dr. Nancy Stockbine. It is a member of Group 1 as determined by limited sequence analysis and can invade HeLa cells. Pathogenicity and virulence have been verified during in vitro experimentation, and multiple plasmids are present in this strain. This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. Shigella spp. are extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This species is uncommon except in India, where it was first isolated. Progression to clinical dysentery occurs in most patients infected with this organism.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_007385:157516:1664251664251686262202Shigella sonnei Ss046 plasmid pSS_046, complete sequenceTraD protein01345
NC_016846:24500:5201252012542912280Klebsiella pneumoniae subsp. pneumoniae HS11286 plasmid pKPHS2,conjugal transfer protein TraD0969
NC_007607:87000:9356593565950791515Shigella dysenteriae Sd197 plasmid pSD1_197, complete sequencehypothetical protein0912
NC_009787:17344:4718471869492232Escherichia coli E24377A plasmid pETEC_35, complete sequencetype IV conjugative transfer system coupling protein TraD0676
NC_009998:62000:7347873478756042127Shewanella baltica OS195 plasmid pS19501, complete sequencetype IV conjugative transfer system coupling protein TraD2e-121436
NC_004460:708416:7124647124647145572094Vibrio vulnificus CMCP6 chromosome II, complete sequenceType IV secretory pathway, VirD4 component3e-107389
NC_010606:25090:2655826558287172160Acinetobacter baumannii ACICU plasmid pACICU2, complete sequenceType IV secretory pathway, VirD4 component4e-71270
NC_010793:1468849:1468849146884914703841536Orientia tsutsugamushi str. Ikeda, complete genomeputative conjugative transfer protein TraD1e-69265
NC_008322:1186000:1186944118694411889171974Shewanella sp. MR-7, complete genomehypothetical protein6e-70265
NC_010793:1811401:1863476186347618652301755Orientia tsutsugamushi str. Ikeda, complete genomeputative conjugative transfer protein TraD2e-69263
NC_009488:89844:1125211125211142781758Orientia tsutsugamushi str. Boryong, complete genomeconjugative transfer protein1e-68261
NC_007608:97092:101798101798102211414Shigella boydii Sb227 plasmid pSB4_227, complete sequencemembrane protein, fragment5e-67256
NC_017044:702483:7220847220847237781695Rickettsia parkeri str. Portsmouth chromosome, complete genomeconjugative transfer protein TraD4e-66253
NC_010793:1508974:1513498151349815152521755Orientia tsutsugamushi str. Ikeda, complete genomeputative conjugative transfer protein TraD2e-65250
NC_010793:1158279:1169124116912411708781755Orientia tsutsugamushi str. Ikeda, complete genomeputative conjugative transfer protein TraD2e-65250
NC_010793:416849:4208424208424225961755Orientia tsutsugamushi str. Ikeda, complete genomeputative conjugative transfer protein TraD2e-65250
NC_007722:168937:1869601869601892992340Erythrobacter litoralis HTCC2594, complete genomeTraD1e-63244
NC_007722:851129:8667998667998691382340Erythrobacter litoralis HTCC2594, complete genomeTraD5e-63242
NC_009007:57804:7373273732760142283Rhodobacter sphaeroides 2.4.1 plasmid A, partial sequenceTraG6e-62239
NC_007607:87000:949619496195374414Shigella dysenteriae Sd197 plasmid pSD1_197, complete sequencehypothetical protein2e-61237
NC_007722:2954876:2956825295682529590802256Erythrobacter litoralis HTCC2594, complete genomeTraD1e-58228
NC_010793:1628500:1641810164181016428201011Orientia tsutsugamushi str. Ikeda, complete genomeputative conjugative transfer protein TraD4e-53210
NC_009488:854500:857766857766858722957Orientia tsutsugamushi str. Boryong, complete genomeconjugative transfer protein1e-49198
NC_009488:803873:809270809270810226957Orientia tsutsugamushi str. Boryong, complete genomeconjugative transfer protein3e-49196
NC_009488:1249492:125489812548981255854957Orientia tsutsugamushi str. Boryong, complete genomeconjugative transfer protein3e-49196
NC_009488:1465781:1479205147920514803501146Orientia tsutsugamushi str. Boryong, complete genomeconjugative transfer protein8e-49195
NC_009488:1391975:1405801140580114069461146Orientia tsutsugamushi str. Boryong, complete genomeconjugative transfer protein4e-48193
NC_009488:1673756:1685432168543216865771146Orientia tsutsugamushi str. Boryong, complete genomeconjugative transfer protein4e-48193
NC_009484:2660048:2677156267715626790061851Acidiphilium cryptum JF-5 chromosome, complete genomeType IV secretory pathway VirD4 components-like protein1e-47191
NC_014819:25765:4626046260488752616Asticcacaulis excentricus CB 48 plasmid pASTEX02, completehypothetical protein2e-46187
NC_011891:1225000:1245654124565412471831530Anaeromyxobacter dehalogenans 2CP-1, complete genometype IV secretion system protein VirD42e-45184
NC_017028:1030000:104422810442281045058831Candidatus Rickettsia amblyommii str. GAT-30V chromosome, completeputative conjugative transfer protein TraD4e-44179
NC_011296:281930:2970702970702987821713Thermodesulfovibrio yellowstonii DSM 11347, complete genomeputative conjugative transfer protein TraD9e-44179
NC_011916:467106:4915124915124933291818Caulobacter crescentus NA1000 chromosome, complete genomeconjugation protein, ATP binding domain trwB3e-43177
NC_015458:327009:3591473591473608261680Pusillimonas sp. T7-7 chromosome, complete genomeTrwB5e-42172
NC_010170:3908500:3929234392923439308801647Bordetella petrii, complete genometype IV secretion system protein VirD42e-38161
NC_012483:3731542:3752837375283737548311995Acidobacterium capsulatum ATCC 51196, complete genomehypothetical protein1e-36155
NC_012483:3672768:3674604367460436766042001Acidobacterium capsulatum ATCC 51196, complete genomehypothetical protein7e-35149
NC_016626:1751159:1754229175422917558721644Burkholderia sp. YI23 plasmid byi_1p, complete sequenceputative TraB protein, type IV secretion system1e-33145
NC_016631:3917253:3934403393440339363731971Granulicella mallensis MP5ACTX8 chromosome, complete genomeType IV secretion system, TraD, DNA-binding domain protein3e-33144
NC_017044:702483:719163719163719666504Rickettsia parkeri str. Portsmouth chromosome, complete genomeputative conjugative transfer protein TraD1e-31138
NC_009488:1430693:143360714336071434488882Orientia tsutsugamushi str. Boryong, complete genomeconjugative transfer protein2e-29130
NC_020453:3950838:3988683398868339904941812Agromonas oligotrophica S58 DNA, complete genomeputative type IV secretory pathway VirD4 components4e-25116
NC_004851:191709:197923197923198108186Shigella flexneri 2a str. 301 plasmid pCP301, complete sequenceDNA transport protein2e-24114
NC_017319:192482:197905197905198036132Shigella flexneri 2002017 plasmid pSFxv_1, complete sequenceTraD protein2e-1895.1
NC_007404:1776147:1776147177614717785012355Thiobacillus denitrificans ATCC 25259, complete genomeputative type IV secretory pathway VirD4 components2e-1791.7
NC_015850:1006980:1013904101390410157931890Acidithiobacillus caldus SM-1 chromosome, complete genomehypothetical protein8e-1685.9
NC_010943:3069082:3098061309806130999351875Stenotrophomonas maltophilia K279a, complete genomeputative type IV secretory protein conjugation protein TraD4e-1377
NC_016814:18000:3264032640347392100Sinorhizobium fredii HH103 plasmid pSfHH103c complete sequenceProtein virD44e-0860.5
NC_013926:974668:9746689746689764761809Aciduliprofundum boonei T469 chromosome, complete genomeType IV secretory pathway VirD4 protein-like protein2e-0758.5
NC_017361:1528239:1543901154390115460332133Helicobacter pylori SouthAfrica7 chromosome, complete genomeconjugal transfer protein (traG)4e-0757.4
NC_011729:2732163:2747512274751227492211710Cyanothece sp. PCC 7424 chromosome, complete genometransfer complex protein TrsK-like protein7e-0756.2
NC_011987:53760:5376053760561232364Agrobacterium radiobacter K84 plasmid pAtK84c, complete sequenceTRAG protein4e-0653.9
NC_014502:113839:1141601141601160821923Cyanothece sp. PCC 7822 plasmid Cy782203, complete sequenceTRAG family protein5e-0653.5
NC_011333:1040192:1060476106047610622031728Helicobacter pylori G27 chromosome, complete genomecag island DNA transfer protein6e-0653.5