Pre_GI: BLASTP Hits

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Query: NC_010660:175200:176293 Shigella boydii CDC 3083-94 plasmid pBS512_211, complete sequence

Start: 176293, End: 177243, Length: 951

Host Lineage: Shigella boydii; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain (strain BS512; serotype 18) was originally isolated from a 12-year-old boy in Arizona, USA by Dr. Nancy Stockbine. It is a member of Group 1 as determined by limited sequence analysis and can invade HeLa cells. Pathogenicity and virulence have been verified during in vitro experimentation, and multiple plasmids are present in this strain. This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. Shigella spp. are extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This species is uncommon except in India, where it was first isolated. Progression to clinical dysentery occurs in most patients infected with this organism.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_007608:97092:981859818599135951Shigella boydii Sb227 plasmid pSB4_227, complete sequenceVirK0655
NC_009790:42112:614456144562395951Escherichia coli E24377A plasmid pETEC_74, complete sequencehypothetical protein0653
NC_011750:4947500:496427749642774965227951Escherichia coli IAI39 chromosome, complete genomeregulator of virG protein0651
NC_017328:1075535:110263211026321103582951Shigella flexneri 2002017 chromosome, complete genomeVirK-like protein0650
NC_007385:157516:158609158609159559951Shigella sonnei Ss046 plasmid pSS_046, complete sequenceVirK0632
NC_007607:87000:880308803088980951Shigella dysenteriae Sd197 plasmid pSD1_197, complete sequenceVirK0632
NC_017319:192482:193575193575194525951Shigella flexneri 2002017 plasmid pSFxv_1, complete sequenceVirK, required for proper localization of IcsA (VirG) at the surface of bacteria1e-180632
NC_004851:191709:193647193647194597951Shigella flexneri 2a str. 301 plasmid pCP301, complete sequenceVirK, required for proper localization of IcsA (VirG) at the surface of bacteria1e-179629
NC_003198:2769449:278143527814352782364930Salmonella enterica subsp. enterica serovar Typhi str. CT18,virulence protein4e-79295
NC_004631:2755306:276729227672922768221930Salmonella enterica subsp. enterica serovar Typhi Ty2, completevirulence protein4e-79295
NC_016832:2743801:275459127545912755520930Salmonella enterica subsp. enterica serovar Typhi str. P-stx-12,hypothetical protein4e-79295
NC_003197:2894344:292837329283732929302930Salmonella typhimurium LT2, complete genomevirulence protein7e-79294
NC_016810:2943912:295094929509492951878930Salmonella enterica subsp. enterica serovar Typhimurium strvirulence protein7e-79294
NC_016856:2896630:294860829486082949537930Salmonella enterica subsp. enterica serovar Typhimurium str. 14028Svirulence protein7e-79294
NC_016857:2943912:295094929509492951878930Salmonella enterica subsp. enterica serovar Typhimurium str. ST4/74virulence protein7e-79294
NC_016860:2917910:295193929519392952868930Salmonella enterica subsp. enterica serovar Typhimurium strvirulence protein7e-79294
NC_016863:2844883:289686128968612897790930Salmonella enterica subsp. enterica serovar Typhimurium str. UK-1virulence protein7e-79294
NC_006905:2857699:288305728830572883986930Salmonella enterica subsp. enterica serovar Choleraesuis strvirulence gene; homologous sequence to virK in Shigella5e-79294
NC_011094:2791719:283549928354992836428930Salmonella enterica subsp. enterica serovar Schwarzengrund strhypothetical protein5e-79294
NC_012125:2826624:286358928635892864518930Salmonella enterica subsp. enterica serovar Paratyphi C strainvirulence protein5e-79294
NC_011083:2847318:290288329028832903812930Salmonella enterica subsp. enterica serovar Heidelberg str. SL476,virulence protein5e-79294
NC_011149:2829811:283683428368342837763930Salmonella enterica subsp. enterica serovar Agona str. SL483,virulence protein1e-78293
NC_011080:2897977:290501229050122905941930Salmonella enterica subsp. enterica serovar Newport str. SL254,virulence protein8e-79293
NC_016831:2779864:279066227906622791591930Salmonella enterica subsp. enterica serovar Gallinarum/pullorumvirulence protein3e-78292
NC_011294:2802502:281329928132992814228930Salmonella enterica subsp. enterica serovar Enteritidis strvirulence protein3e-78292
NC_011274:2793355:280415228041522805081930Salmonella enterica subsp. enterica serovar Gallinarum str. 287/91virulence protein3e-78292
NC_011205:2962270:297306629730662973995930Salmonella enterica subsp. enterica serovar Dublin str. CT_02021853hypothetical protein3e-78292
NC_010102:2881714:289253528925352893443909Salmonella enterica subsp. enterica serovar Paratyphi B str. SPB7,hypothetical protein4e-78291
NC_010067:171053:179299179299180234936Salmonella enterica subsp. arizonae serovar 62:z4,z23:--, completehypothetical protein1e-76286
NC_017046:2943929:294969029496902950466777Salmonella enterica subsp. enterica serovar Typhimurium str. 798virulence protein2e-59229
NC_013282:1842412:186906918690691870001933Cronobacter turicensis, complete genomehypothetical protein2e-47189
NC_013892:3745749:374871537487153749650936Xenorhabdus bovienii SS-2004 chromosome, complete genomehypothetical protein8e-43174
NC_020211:996497:102608110260811027010930Serratia marcescens WW4, complete genomehypothetical protein3e-36152
NC_017068:2786391:279456827945682795470903Selenomonas ruminantium subsp. lactilytica TAM6421, completehypothetical protein2e-1583.6
NC_009053:393700:403856403856404728873Actinobacillus pleuropneumoniae L20, complete genomehypothetical protein1e-1170.9
NC_010939:405477:431568431568432440873Actinobacillus pleuropneumoniae serovar 7 str. AP76, completehypothetical protein1e-1170.9
NC_010278:398521:408686408686409558873Actinobacillus pleuropneumoniae serovar 3 str. JL03 chromosome,hypothetical protein1e-1170.9
NC_008309:1553399:155339915533991554358960Haemophilus somnus 129PT, complete genomehypothetical protein3e-1169.7
NC_015437:438538:453418453418454320903Selenomonas sputigena ATCC 35185 chromosome, complete genomeprotein of unknown function DUF5353e-1169.7
NC_017046:2943929:295043329504332950618186Salmonella enterica subsp. enterica serovar Typhimurium str. 798virulence protein1e-0963.9