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Query: NC_010658:4494103:4500171 Shigella boydii CDC 3083-94, complete genome

Start: 4500171, End: 4500587, Length: 417

Host Lineage: Shigella boydii; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain (strain BS512; serotype 18) was originally isolated from a 12-year-old boy in Arizona, USA by Dr. Nancy Stockbine. It is a member of Group 1 as determined by limited sequence analysis and can invade HeLa cells. Pathogenicity and virulence have been verified during in vitro experimentation, and multiple plasmids are present in this strain. This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. Shigella spp. are extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This species is uncommon except in India, where it was first isolated. Progression to clinical dysentery occurs in most patients infected with this organism.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012967:4449576:446160544616054462021417Escherichia coli B str. REL606 chromosome, complete genomehypothetical protein2e-50197
NC_012947:3947238:395208739520873952503417Escherichia coli 'BL21-Gold(DE3)pLysS AG' chromosome, completehypothetical protein2e-50197
NC_011742:4795733:480779348077934808209417Escherichia coli S88 chromosome, complete genomehypothetical protein2e-50197
NC_007613:4217557:424369042436904244106417Shigella boydii Sb227, complete genomehypothetical protein2e-50197
AC_000091:4472000:448315344831534483569417Escherichia coli W3110 DNA, complete genomehypothetical protein2e-50197
NC_010498:4821519:483354948335494833965417Escherichia coli SMS-3-5, complete genomehypothetical protein2e-50197
NC_000913:4462782:447649644764964476912417Escherichia coli K12, complete genomehypothetical protein2e-50197
NC_010473:4564590:457830445783044578720417Escherichia coli str. K-12 substr. DH10B, complete genomeribonuclease E inhibitor protein2e-50197
NC_014121:677799:679897679897680322426Enterobacter cloacae subsp. cloacae ATCC 13047 chromosome, completehypothetical protein1e-36151
NC_015968:511282:516969516969517391423Enterobacter asburiae LF7a chromosome, complete genomehypothetical protein1e-36151
NC_016514:506611:511699511699512124426Enterobacter cloacae EcWSU1 chromosome, complete genomeregulator of ribonuclease activity B4e-36149
NC_017047:4298207:433213943321394332564426Rahnella aquatilis HX2 chromosome, complete genomeRNase E inhibitor protein7e-36149
NC_015061:4203767:423822442382244238649426Rahnella sp. Y9602 chromosome, complete genomehypothetical protein7e-36149
NC_012668:160357:184754184754185176423Vibrio cholerae MJ-1236 chromosome 1, complete sequencehypothetical protein3e-29127
NC_015633:2919501:293478429347842935212429Vibrio anguillarum 775 chromosome chromosome I, complete sequencehypothetical protein6e-28122
NC_010519:416658:433580433580433993414Haemophilus somnus 2336 chromosome, complete genomehypothetical protein1e-27121
NC_008309:1851189:185635918563591856772414Haemophilus somnus 129PT, complete genomehypothetical protein1e-27121