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Query: NC_010658:4494103:4499623 Shigella boydii CDC 3083-94, complete genome

Start: 4499623, End: 4500018, Length: 396

Host Lineage: Shigella boydii; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain (strain BS512; serotype 18) was originally isolated from a 12-year-old boy in Arizona, USA by Dr. Nancy Stockbine. It is a member of Group 1 as determined by limited sequence analysis and can invade HeLa cells. Pathogenicity and virulence have been verified during in vitro experimentation, and multiple plasmids are present in this strain. This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. Shigella spp. are extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This species is uncommon except in India, where it was first isolated. Progression to clinical dysentery occurs in most patients infected with this organism.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_007613:4217557:424425942442594244654396Shigella boydii Sb227, complete genomeputative acetyltransferase5e-64242
AC_000091:4472000:448371444837144484217504Escherichia coli W3110 DNA, complete genomepredicted acetyltransferase1e-63241
NC_010473:4564590:457886545788654579368504Escherichia coli str. K-12 substr. DH10B, complete genomepredicted acetyltransferase1e-63241
NC_000913:4462782:447705744770574477560504Escherichia coli K12, complete genomepredicted acetyltransferase1e-63241
NC_010498:4821519:483401148340114834514504Escherichia coli SMS-3-5, complete genomeacetyltransferase1e-63241
NC_011742:4795733:480825548082554808758504Escherichia coli S88 chromosome, complete genomeacetyltransferase3e-63239
NC_012967:4449576:446206744620674462570504Escherichia coli B str. REL606 chromosome, complete genomeputative acetyltransferase8e-63238
NC_012947:3947238:395153839515383952041504Escherichia coli 'BL21-Gold(DE3)pLysS AG' chromosome, completeGCN5-related N-acetyltransferase8e-63238
NC_015061:4203767:423372142337214234224504Rahnella sp. Y9602 chromosome, complete genomeGCN5-related N-acetyltransferase4e-40162
NC_017047:4298207:432763643276364328139504Rahnella aquatilis HX2 chromosome, complete genomeputative acetyltransferase4e-40162
NC_014623:8763551:878183187818318782340510Stigmatella aurantiaca DW4/3-1 chromosome, complete genomeGNAT family acetyltransferase3e-22103
NC_021182:4088000:409471040947104095180471Clostridium pasteurianum BC1, complete genomeacetyltransferase1e-1581.6
NC_008319:1950889:196897219689721969484513Synechococcus sp. CC9311, complete genomeprobable acetyltransferase4e-1580.1
NC_003910:2588000:260556426055642606046483Colwellia psychrerythraea 34H, complete genomeacetyltransferase, GNAT family3e-1063.9
NC_004193:3215500:322058632205863221059474Oceanobacillus iheyensis HTE831, complete genomehypothetical protein9e-0958.9
NC_015385:965341:971093971093971890798Treponema succinifaciens DSM 2489 chromosome, complete genomeGCN5-related N-acetyltransferase7e-0649.3