Pre_GI: BLASTP Hits

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Query: NC_010520:2668702:2684240 Clostridium botulinum A3 str. Loch Maree, complete genome

Start: 2684240, End: 2684719, Length: 480

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum A3 str. Loch Maree was isolated from duck liver paste during a botulism outbreak at a hotel in the Scottish highlands in 1922. This was the first and worst outbreak of botulism in the United Kingdom (UK). This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017297:2635892:267021026702102670689480Clostridium botulinum F str. 230613 chromosome, complete genomehypothetical protein2e-53207
NC_009699:2654672:267006226700622670541480Clostridium botulinum F str. Langeland chromosome, complete genomehypothetical protein2e-53207
NC_010516:2594159:260974326097432610222480Clostridium botulinum B1 str. Okra, complete genomehypothetical protein2e-53207
NC_012563:2761570:279606827960682796547480Clostridium botulinum A2 str. Kyoto, complete genomehypothetical protein2e-53207
NC_009495:2606238:262169826216982622177480Clostridium botulinum A str. ATCC 3502 chromosome, complete genomehypothetical protein5e-53206
NC_009697:2478261:249381524938152494294480Clostridium botulinum A str. ATCC 19397 chromosome, completehypothetical protein5e-53206
NC_009698:2450606:246616024661602466639480Clostridium botulinum A str. Hall chromosome, complete genomehypothetical protein5e-53206
NC_012658:2641446:267712526771252677604480Clostridium botulinum Ba4 str. 657 chromosome, complete genomehypothetical protein1e-52204
NC_015732:2057895:206444820644482064930483Spirochaeta caldaria DSM 7334 chromosome, complete genomehypothetical protein1e-1789
NC_010556:316996:319808319808320290483Exiguobacterium sibiricum 255-15, complete genomehypothetical protein6e-1373.2
NC_016048:797762:840797840797841279483Oscillibacter valericigenes Sjm18-20, complete genomehypothetical protein9e-0855.8