Pre_GI: BLASTP Hits

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Query: NC_010520:2668702:2683708 Clostridium botulinum A3 str. Loch Maree, complete genome

Start: 2683708, End: 2684235, Length: 528

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum A3 str. Loch Maree was isolated from duck liver paste during a botulism outbreak at a hotel in the Scottish highlands in 1922. This was the first and worst outbreak of botulism in the United Kingdom (UK). This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017297:2635892:266967826696782670205528Clostridium botulinum F str. 230613 chromosome, complete genomehypothetical protein1e-65248
NC_009699:2654672:266953026695302670057528Clostridium botulinum F str. Langeland chromosome, complete genomehypothetical protein1e-65248
NC_009698:2450606:246562824656282466155528Clostridium botulinum A str. Hall chromosome, complete genomepermease1e-65248
NC_009495:2606238:262116626211662621693528Clostridium botulinum A str. ATCC 3502 chromosome, complete genomehypothetical protein1e-65248
NC_012563:2761570:279553627955362796063528Clostridium botulinum A2 str. Kyoto, complete genomehypothetical protein1e-65248
NC_010516:2594159:260921126092112609738528Clostridium botulinum B1 str. Okra, complete genomehypothetical protein3e-65247
NC_012658:2641446:267659326765932677120528Clostridium botulinum Ba4 str. 657 chromosome, complete genomehypothetical protein2e-65247
NC_009697:2478261:249328324932832493618336Clostridium botulinum A str. ATCC 19397 chromosome, completehypothetical protein6e-46183
NC_015732:2057895:206391520639152064451537Spirochaeta caldaria DSM 7334 chromosome, complete genomehypothetical protein9e-23106
NC_016048:797762:841276841276841998723Oscillibacter valericigenes Sjm18-20, complete genomehypothetical protein2e-1375.1
NC_010556:316996:319302319302319811510Exiguobacterium sibiricum 255-15, complete genomehypothetical protein4e-1167.4