Pre_GI: BLASTP Hits

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Query: NC_010520:2668702:2683114 Clostridium botulinum A3 str. Loch Maree, complete genome

Start: 2683114, End: 2683230, Length: 117

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum A3 str. Loch Maree was isolated from duck liver paste during a botulism outbreak at a hotel in the Scottish highlands in 1922. This was the first and worst outbreak of botulism in the United Kingdom (UK). This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009699:2654672:266909726690972669213117Clostridium botulinum F str. Langeland chromosome, complete genomehypothetical protein1e-1375.1
NC_012658:2641446:267599926759992676115117Clostridium botulinum Ba4 str. 657 chromosome, complete genomehypothetical protein9e-1372
NC_017297:2635892:266924526692452669361117Clostridium botulinum F str. 230613 chromosome, complete genomehypothetical protein1e-1375.1
NC_009697:2478261:249268924926892492805117Clostridium botulinum A str. ATCC 19397 chromosome, completehypothetical protein3e-1373.9
NC_010516:2594159:260861826086182608734117Clostridium botulinum B1 str. Okra, complete genomehypothetical protein1e-1375.1
NC_012563:2761570:279494227949422795058117Clostridium botulinum A2 str. Kyoto, complete genomehypothetical protein1e-1375.1