Pre_GI: BLASTP Hits

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Query: NC_010520:2668702:2675934 Clostridium botulinum A3 str. Loch Maree, complete genome

Start: 2675934, End: 2676659, Length: 726

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum A3 str. Loch Maree was isolated from duck liver paste during a botulism outbreak at a hotel in the Scottish highlands in 1922. This was the first and worst outbreak of botulism in the United Kingdom (UK). This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012563:2761570:278776227877622788487726Clostridium botulinum A2 str. Kyoto, complete genomeD-proline reductase, gamma subunit PrdB, selenocysteine-containing8e-138489
NC_010516:2594159:260143826014382602163726Clostridium botulinum B1 str. Okra, complete genomeD-proline reductase, PrdB subunit, selenocysteine-containing4e-137487
NC_010516:2567911:258331925833192584038720Clostridium botulinum B1 str. Okra, complete genomeputative D-proline reductase, PrdB subunit, selenocysteine-containing2e-127454
NC_012563:2761570:276961627696162770335720Clostridium botulinum A2 str. Kyoto, complete genomeD-proline reductase, gamma subunit PrdB, selenocysteine-containing2e-127454
NC_009089:3782000:379269537926953793420726Clostridium difficile 630, complete genomeproline reductase5e-110397
NC_017297:2635892:266234026623402662792453Clostridium botulinum F str. 230613 chromosome, complete genome3e-83308
NC_012658:2641446:265360626536062654052447Clostridium botulinum Ba4 str. 657 chromosome, complete genomeputative D-proline reductase, PrdB subunit9e-77286
NC_017297:2635892:264420826442082644654447Clostridium botulinum F str. 230613 chromosome, complete genome1e-76285
NC_017297:2635892:266206726620672662312246Clostridium botulinum F str. 230613 chromosome, complete genome1e-38159
NC_012658:2641446:265333326533332653578246Clostridium botulinum Ba4 str. 657 chromosome, complete genomePrdB protein6e-37154
NC_010718:497222:5021915021915034981308Natranaerobius thermophilus JW/NM-WN-LF, complete genomeselenoprotein B, glycine/betaine/sarcosine/D-proline reductase family1e-1583.2
NC_010516:1382000:1389249138924913905501302Clostridium botulinum B1 str. Okra, complete genomeglycine reductase complex component B, gamma subunit, selenocysteine-containing3e-1582.4
NC_010520:1427981:1435777143577714370781302Clostridium botulinum A3 str. Loch Maree, complete genomeglycine reductase complex component B, gamma subunit, selenocysteine-containing3e-1582
NC_012563:1464000:1471349147134914726501302Clostridium botulinum A2 str. Kyoto, complete genomeglycine reductase, selenoprotein B3e-1582
NC_014330:2026193:2035146203514620364441299Brachyspira pilosicoli 95/1000 chromosome, complete genomeglycine/sarcosine/betaine reductase selenoprotein GrdB2e-1479.7
NC_013223:1090397:112428511242851124746462Desulfohalobium retbaense DSM 5692, complete genomehypothetical protein5e-1271.6
NC_014328:3066628:3076704307670430780171314Clostridium ljungdahlii ATCC 49587 chromosome, complete genomebetaine reductase complex component B subunit gamma4e-1168.6
NC_016025:65923:921729217292648477Candidatus Chloracidobacterium thermophilum B chromosome chromosomehypothetical protein8e-0960.8
NC_014328:2990790:3022254302225430235671314Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeglycine reductase complex component B subunit gamma4e-0651.6