Pre_GI: BLASTP Hits

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Query: NC_010520:2668702:2674817 Clostridium botulinum A3 str. Loch Maree, complete genome

Start: 2674817, End: 2675593, Length: 777

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum A3 str. Loch Maree was isolated from duck liver paste during a botulism outbreak at a hotel in the Scottish highlands in 1922. This was the first and worst outbreak of botulism in the United Kingdom (UK). This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009698:2450606:245673424567342457510777Clostridium botulinum A str. Hall chromosome, complete genomePrdD protein5e-148523
NC_009697:2478261:248438924843892485165777Clostridium botulinum A str. ATCC 19397 chromosome, completePrdD protein5e-148523
NC_009495:2606238:261227626122762613052777Clostridium botulinum A str. ATCC 3502 chromosome, complete genomePrdD protein2e-147521
NC_017297:2635892:266095026609502661726777Clostridium botulinum F str. 230613 chromosome, complete genomeglycine/sarcosine/betaine reductase, component B subunits alpha and beta4e-147520
NC_009699:2654672:266080026608002661576777Clostridium botulinum F str. Langeland chromosome, complete genome4e-147520
NC_012563:2761570:278664527866452787421777Clostridium botulinum A2 str. Kyoto, complete genome1e-146519
NC_010516:2594159:260032126003212601097777Clostridium botulinum B1 str. Okra, complete genomePrdD protein2e-146517
NC_012658:2641446:266770626677062668464759Clostridium botulinum Ba4 str. 657 chromosome, complete genome1e-143508
NC_009089:3782000:379185737918573792624768Clostridium difficile 630, complete genomehypothetical protein3e-75281
NC_017179:3621306:362835936283593629117759Clostridium difficile BI1, complete genomehypothetical protein4e-75281
NC_013315:3613288:362034136203413621099759Clostridium difficile CD196 chromosome, complete genomehypothetical protein4e-75281
NC_014614:2333890:234068223406822341446765Clostridium sticklandii, complete genomeputative uncharacterized protein (PrdD)3e-65248
NC_014614:2333890:2342523234252323444121890Clostridium sticklandii, complete genomeD-proline reductase proprotein prdA [Contains: D-proline reductase subunit beta (D-proline reductase 45 kDa subunit); D-proline reductase subunit alph2e-52205
NC_009089:3782000:3793823379382337957031881Clostridium difficile 630, complete genomeproline reductase subunit proprotein4e-51201
NC_013315:3613288:3622307362230736241871881Clostridium difficile CD196 chromosome, complete genomeproline reductase subunit proprotein4e-51201
NC_017179:3621306:3630325363032536322051881Clostridium difficile BI1, complete genomeproline reductase subunit proprotein4e-51201
NC_012563:2761570:2770649277064927727632115Clostridium botulinum A2 str. Kyoto, complete genomeD-proline reductase, PrdA proprotein2e-47189
NC_010516:2567911:2584352258435225864662115Clostridium botulinum B1 str. Okra, complete genomeputative D-proline reductase, PrdA proprotein2e-47189
NC_017297:2635892:2644968264496826470822115Clostridium botulinum F str. 230613 chromosome, complete genomeD-proline reductase subunit PrdA2e-47189
NC_009699:2635745:2644821264482126469352115Clostridium botulinum F str. Langeland chromosome, complete genomeD-proline reductase subunit PrdA2e-47189
NC_012658:2641446:2654366265436626564802115Clostridium botulinum Ba4 str. 657 chromosome, complete genomeD-proline reductase, PrdA proprotein2e-47189
NC_010520:2668702:2677019267701926791302112Clostridium botulinum A3 str. Loch Maree, complete genomeputative D-proline reductase, PrdA proprotein2e-46185
NC_009697:2478261:2486591248659124887022112Clostridium botulinum A str. ATCC 19397 chromosome, completeD-proline reductase subunit PrdA2e-46185
NC_009698:2450606:2458936245893624610472112Clostridium botulinum A str. Hall chromosome, complete genomeD-proline reductase subunit PrdA2e-46185
NC_012658:2641446:2669909266990926720202112Clostridium botulinum Ba4 str. 657 chromosome, complete genomeD-proline reductase, PrdA proprotein5e-46184
NC_012563:2761570:2788847278884727909552109Clostridium botulinum A2 str. Kyoto, complete genomeD-proline reductase, PrdA proprotein5e-46184
NC_009495:2606238:2614478261447826165862109Clostridium botulinum A str. ATCC 3502 chromosome, complete genomesubunit of proline reductase6e-46184
NC_017297:2635892:2663152266315226652602109Clostridium botulinum F str. 230613 chromosome, complete genomeputative D-proline reductase, PrdA proprotein7e-46184
NC_009699:2654672:2663002266300226651102109Clostridium botulinum F str. Langeland chromosome, complete genomeD-proline reductase subunit PrdA7e-46184
NC_010516:2594159:2602523260252326046312109Clostridium botulinum B1 str. Okra, complete genomeputative D-proline reductase, PrdA proprotein7e-46184