Pre_GI: BLASTP Hits

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Query: NC_010520:1586000:1595199 Clostridium botulinum A3 str. Loch Maree, complete genome

Start: 1595199, End: 1597007, Length: 1809

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum A3 str. Loch Maree was isolated from duck liver paste during a botulism outbreak at a hotel in the Scottish highlands in 1922. This was the first and worst outbreak of botulism in the United Kingdom (UK). This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009495:1516000:1522749152274915245571809Clostridium botulinum A str. ATCC 3502 chromosome, complete genomepeptide ABC transporter Pep4E family, permease0818
NC_008600:4626464:4626464462646446284401977Bacillus thuringiensis str. Al Hakam, complete genomeABC transporter, permease component1e-1998.6
NC_011772:4763542:4764291476429147662641974Bacillus cereus G9842, complete genomeABC transporter, permease component2e-1790.9
NC_017200:4632000:4632044463204446339991956Bacillus thuringiensis serovar finitimus YBT-020 chromosome,ABC transporter permease8e-1789
NC_017200:4632000:4634769463476946367421974Bacillus thuringiensis serovar finitimus YBT-020 chromosome,permease domain-containing protein6e-1686.3
NC_012472:4630485:4630485463048546324581974Bacillus cereus 03BB102, complete genomehypothetical protein2e-1584.7
NC_009725:3763922:3765161376516137670291869Bacillus amyloliquefaciens FZB42, complete genomeYxdM8e-1272.8
NC_009328:293000:3431163431163449871872Geobacillus thermodenitrificans NG80-2 chromosome, complete genomeABC transporter permease7e-1272.8
NC_020410:3755978:3757342375734237592101869Bacillus amyloliquefaciens subsp. plantarum UCMB5036 completeABC transporter (permease); efflux of cationic peptides2e-1171.2
NC_017200:4240500:4257387425738742593091923Bacillus thuringiensis serovar finitimus YBT-020 chromosome,ABC transporter permease2e-0861.6
NC_004565:20256:2685326853287811929Clostridium tetani E88 plasmid pE88, complete sequenceABC transporter-associated permease2e-0758.2
NC_017200:4240500:4255424425542442573371914Bacillus thuringiensis serovar finitimus YBT-020 chromosome,ABC transporter permease2e-0655.1